I-DMF-DMA CAS 4637-24-5 N,N-Dimethylformamide Dimethyl Acetal Purity >99.0% (GC) Intengiso eshushu kwiFactory

Ekubeni i-Meenvin ibike ukulungiswa kwe-DMF-DMA (N, N-Dimethylformamide Dimethyl Acetal) kwi-1956, i-DMF-DMA iye yaba yinto esetyenziswa rhoqo kwi-organic synthesis.
I-DMF-DMA isetyenziswa ngokubanzi kulwakhiwo lwamakhonkco amahlanu okanye amathandathu anelungu le-heterocyclic kwi-reaction yokuvala umsesane.I-DMF-DMA inempendulo ethambileyo kunye nesivuno esikhulu, ngakumbi kwiikhompawundi eziphezulu zokuxhathisa.
Ulwakhiwo jikelele lwe-amide acetal compounds lulolu hlobo lulandelayo:
Eyona nto isetyenziswa kakhulu yi-DMF-DMA kunye ne-DMF-DEA, i-amide acetal i-hydrolyzed ngokulula, ingaba yi-esterified, i-amidine, i-alkylation kunye ne-cyclization reactions.
I-athomu ye-carbon ephakathi ye-DMF-DMA idibaniswe nee-heteroatom ezintathu kunye ne-electronegative enkulu, eyenza ibe nomsebenzi onamandla we-electrophilic.Ngaphantsi kwesenzo se-asidi, iqela le-alkoxy kulula ukulishiya, kwaye ii-ion ezintle ezinomsebenzi onamandla we-electrophilic zifunyenwe.Ukusabela kwe-DMF-DMA ikakhulu kubandakanya ukusabela kwe-methylation kunye nokusabela kokwakheka.
"I-One-carbon Syntheson" ye-DMF-DMA
Kwi-loop yokuvala i-loop ebandakanya i-DMF-DMA, i-athomu yekhabhoni enye kuphela kwimveliso ihlala inikezelwa yi-DMF-DMA, ngoko i-DMF-DMA inokuthathwa njenge-carbon syntheson.
DMF-DMA esterification reaction
I-DMF-DMA esterification yenza ukuba ii-acids ezahlukeneyo ze-carboxylic zivelise lula i-C1-20 i-alkyl okanye i-aryl esters, kwaye i-byproducts inokwahlulwa ngokulula nge-distillation.
I-Adipic acid kunye ne-DMF-DMA zaye zaqiniswa kwi-80 degrees kwiiyure ezimbini.I-amide acetal lolona khetho lufanelekileyo lokwenziwa kwe-esterification ye-carboxylic acids enothintelo lwesteric okanye uzinzo olulambathayo.
Ukusabela kwe-DMF-DMA amidination kunye nokukhuselwa kwee-amine eziphambili
I-amide acetals ayinakusabela kuphela nge-amines ephambili, kodwa kunye ne-amides, i-carbamates, i-sulfonamides ukwenza iibhondi ze-hydrocarbon.
Njenge: 2, 4-dimethyl aniline kunye ne-DMF-DMA kwi-80 degrees inokususa ngokukhawuleza i-methanol ukwenza i-dimethamidine compounds.
I-DMF-DMA ingasetyenziselwa njengeqela eliphambili lokukhusela i-amine, iqela eliphambili lokukhusela i-amine (i-2 NH lonke ukhuseleko) mhlawumbi abaninzi abantu bacinga nge-phthalyl, i-pyrrole ring, i-double Boc, i-PMB ephindwe kabini, njl., kodwa ukukhuselwa kwe-DMF-DMA yeprayimari. amine, kwezinye iimeko kwakhona luncedo kakhulu iskimu sokhuselo, off ukhuseleko kufuneka kuphela TFA umxube.
Ukukhuselwa kwe-Amino - i-13 isiseko sokukhusela isingeniso esiqhelekileyo, amava okukhethwa kwesiseko sokukhusela, uluhlu lokusetyenziswa, iimeko zentshayelelo, iimeko zokususa ukwabelana ngesishwankathelo
I-DMF-DMA isabela kunye ne-methyl esebenzayo kunye namaqela e-methylene ukwenza i-carbon-carbon double bonds
Phenylmethylation yeDMF-DMA
I-Heterocyclic compound reactions kwi-DMF-DMA
I-amide i-acetal njengomnikeli wekhabhoni omnye inokusetyenziselwa ukudibanisa iikhompawundi ezahlukeneyo ezintsonkothileyo kunye nezinto zendalo ze-biomimetic.Ii-acetals ze-amil zinokuntywila: 1,2.4 uTriazole, 1.2, i-4 eTerizone, i-I-Isoolone, i-Tyridine, i-Tyralone, i-Tyranone, Pyrazine kunye nolunye uthotho ye-ammonia heterocyclic derivatives, inokuthi yenziwe ioksijini, i-sulphur heterocyclic compounds.
Ngokohlobo lokusabela kweekhemikhali, ukusetyenziswa kwe-amide acetal kwi-heterocyclic compound synthesis inokwahlulwa ibe yimiba emithathu elandelayo.
(1): i-amide acetal kunye ne-amine, i-amide, i-carbamate lipid reaction, yenza iindidi zamakhonkco e-heterocyclic
I-Amidoacetal kunye ne-amine reaction kwi-formamidine intermediate, kwaye emva koko i-intramolecular nucleophilic ring reaction ukuvelisa i-heterocycles ezahlukeneyo, okanye i-formamidine kunye ne-hydrazine, i-hydroxylamine, i-l, i-2, i-alkyl halides enye okanye ezimbini eziqulethe amaqela amabini asebenzayo eekhompawundi kunye nekhonkco elide lekhabhoni, kunye neringi ye-intramolecular. .
I-synthesis ye-heterocyclic compounds ngokuphendula kwe-amide acetals kunye ne-amides, njenge-synthesis ye-l, i-2,4 i-monotriazole derivatives.Okokuqala, i-acetal iphendula kunye ne-amide yenze i-N, i-N 'tritradil, ize iphinde ifakwe i-phenylhydrazine ukuze yenze i-l, i-2,4 ye-monotriazole
I-amide acetals isabela nge-carbamic acid okanye i-acetate ukwenza i-chlorine-equlethe i-heterocyclic rings.I-diactive intermediate eyenziwe ngokusabela kwe-amide acetal ene-aminoethyl ester: i-nn-dimethyl-n 'alkyl-carboxymethyl formamidine, esabela nge-hydrazine okanye i-hydrazine efakwe endaweni.Ngokomzekelo, ukulungiselela i-1,2,4 triazinone-6, i-equation iboniswe ngezantsi.Ukuba uyayiphendula nge-nitro-formate ufumana i-1,2,4 triazolone-5.
Indlela yokusabela yokwenziwa kwe-1,2,4 triazolone-5
Ukubunjwa kwe-1.2.4- triazolidin-5 ngamanyathelo amabini.Okokuqala, i-ethyl carbamate kunye ne-DMF diformaldehyde acetals yenza i-Nn-dimethyl-n-ethoxy-formamidine ephakathi.Okwesibini, iqela le-amino kwi-phenylhydrazine lichitha i-carbon kwi-formamidine, elahlekelwa yi-N (CH3).Emva koko i-ammonia ekwiringi ye-benzene kufuphi ne-phenylhydrazine ihlasela ikhabhoni kwiqela lekhabhoni, yenze i-anion ye-oxygen, kwaye iperile enye ye-electron kwi-oksijini yehla, ilahlekelwe liqela le-ethoxy, kwaye ivelise i-1.2, i-4-triazolone-5.
(II) Ukulungiswa kwee-heterocyclic compounds ngokuphendula kwe-amide acetal kunye ne-amide
Le yeyona ndlela ichaziweyo yokungacoceki kwe-synthesis kumashumi eminyaka akutshanje.Isenzo se-amide acetal silingana ne-Grignard reagent, kodwa imeko yokusabela ye-amide acetal ilula kwaye ilula.
I-amide i-acetal inamaqela amabini asebenzayo, i-reactivity ephezulu, kunye ne-methyl esebenzayo, i-methylene reaction ukuze ifake i-amidine intermediates, ingaba yinto eqhubekayo yokusabela, ukuvalwa kwendandatho, kunye ne-Grignard reagent kunye ne-methylene reaction, kuphela ukwandisa i-carbon chain, ayikwazi ukusabela ngakumbi.Ngokomzekelo, i-synthesis ye-furanochroone derivatives.
(3): iamide acetal kunye nehydroxyl, sulfhydryl compound reaction ukuvelisa ioksijini, iikhompawundi zesulfure heterocyclic
I-synthesis engentla ye-furo mukuxazulula ngumzekelo omhle wokuveliswa kwe-acetal ye-enamine derivatives kunye neqela le-hydroxyl ngokwahlula i-endolateral pole, okukhokelela kwi-oxy-containing heteramine:.Omnye umzekelo: i-catechol kunye ne-DMF -- i-DMA yenza amakhonkco ane-oksijini phambi kwe-dichloromethane.
Ukusabela kwe-DMF--DMA kunye ne-o-mercaptoaniline inokuvelisa i-sulfur-containing heterocyclic ring, ifomyula yokusabela ngolu hlobo lulandelayo.
Uphononongo lwe-DMF-DMA yokuvaleka kweringi kunye nokusabela komntu
(1) I-Batcho-Leimgruber indole synthesis
Ukulungiswa kwezinto ezahlukeneyo zeVindol ezivela kwi-o-nitrotoluene.
Indlela yokusabela
Okokuqala, i-dimethylformamide dimethylacetal, ii-ion ezingalunganga zeqela le-methoxy zishiya ukuvelisa i-intermediate esebenzayo ngakumbi.Ihlaselwa yi-carboanions eyenziwa yi-deprotonation ye-o-nitrotoluene methyl hydrogen kwaye ilahlekelwa yi-methanol ukufumana i-enylamine ekhankanywe ngasentla.Imveliso yeli nyathelo, i-enamine, ifana ne-alkene ene-electron-withdrawing kunye ne-electron-donating substituents eqhotyoshelwe kumacala omabini (i-Push-tsala i-olefin inamandla e-polar kwaye ihlala imnyama ebomvu ngenxa yoluhlu olukhulu lokudibanisa kwi-molecule. Kwinqanaba lesibini. yokusabela, iqela le-nitro liyancitshiswa kwiqela le-amino, lilandelwa yi-cyclization kunye nokuphelisa ukufumana imveliso yokugqibela.
(2) Imifanekiso edibeneyo ye-pyridine derivatives
(3) I-synthesis ye-pyrazole derivatives