Edaravone CAS 89-25-8;I-1-Pheny-3-Methyl-5-Pyrazolone (PMP) Ucoceko oluPhezulu
Ukubonelela ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama: Edaravone
CAS: 89-25-8
Igama | Edaravone |
Izithethantonye | I-1-Pheny-3-Methyl-5-Pyrazolone (PMP);I-MCI-186 |
Inombolo yeCAS | 89-25-8 |
Inombolo yeCAT | RF-PI237 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C10H10N2O |
Ubunzima beMolekyuli | 174.2 |
Ukuxinana | 1.12 g/cm3 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Ikristale etyheli eKhanya okanye umgubo |
Ubunyulu | ≥99.0% |
Indawo yokunyibilika | 127.0 ~ 130.0℃ |
Ilahleko ekomisweni | ≤0.50% |
Intsalela kwi-Ignition | ≤0.30% |
Ukungacoceki Okukodwa | ≤0.50% |
Ukungcola ngokupheleleyo | ≤1.0% |
Iintsimbi ezinzima | ≤20ppm |
Ukunyibilika | Inyibilika kwi-5% ye-Hydrochloric Acid |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | API;AbaPhakathi bamayeza |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
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I-Edaravone (i-CAS 89-25-8) yinto entsha enamandla ye-radical scavenger esetyenziselwa unyango lwezigulane ezine-acute brain infarction.I-Edaravone yi-scavenger enamandla kunye ne-antioxidant ekwazi ukukhusela kwimiphumo ye-ischemia, mhlawumbi ngokuvimbela inkqubo ye-lipoxygenase.Ikhusela kwi-MPTP-induced neurotoxicity.Ithintela i-autophagy.I-Edaravone yathengiswa eJapan ukuze kuphuculwe ukuchacha kwe-neurologic emva kokuphazamiseka kwengqondo.Okwangoku, iiarhente ezininzi ezichazwe njenge-neuroprotectants kwaye zisebenza ngeendlela ezahlukeneyo (ukuthintela ukukhutshwa kwe-glutamate, ukuvalwa kweziteshi ze-calcium, i-lazaroids) ziye zathengiswa ukunyanga iziphumo zokulimala kwengqondo ngenxa yokwenzakala, ischemia okanye ukubanjwa kwentliziyo.I-Edavarone yi-antioxidant yokuqala kunye nomsebenzi wokukrazula okhululekileyo oza kuziswa kule pathology.