EDC·HCl CAS 25952-53-8 Coupling Reagent Purity >99.0% (T) Factory

Inkcazelo emfutshane:

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride

Izithethantonye: EDC·HCl

CAS: 25952-53-8

Ubunyulu: >99.0% (Argentmetric Titration)

Imbonakalo: Umgubo weCrystalline oMhlophe

Ukudibanisa iReagent yePeptides Synthesis

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-1- (3-Dimethylaminopropyl) -3-Ethylcarbodiimide Hydrochloride (EDC · HCl) (CAS: 25952-53-8) enomgangatho ophezulu.I-Ruifu Chemical ibonelela ngothotho lwee-reagents ezikhuselayo kunye ne-coupling reagents.I-Ruifu inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, amanani amancinci kunye nesixa esikhulu esikhoyo.Thenga iEDC·HCl,Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride
Izithethantonye	EDC·HCl;EDAC·HCl;EDCI·HCl;EDC Hydrochloride;I-EDAC Hydrochloride;N-(3-Dimethylaminopropyl)-N′-Ethylcarbodiimide Hydrochloride;I-1-Ethyl-3- (3-Dimethylaminopropyl) carbodiimide Hydrochloride;N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide Hydrochloride;Amanzi e-Soluble Carbodiimide
Ubume beStokhwe	Kwi-Stock, iMveliso yeMisa
Inombolo yeCAS	25952-53-8
Ifomula yeemolekyuli	C8H17N3·HCl
Ubunzima beMolekyuli	191.70 g/mol
Indawo yokunyibilika	110.0 ~ 115.0℃
Ukuxinana	0.877 g/mL ku-20℃(lit.)
Refractive Index n20/D	1.461
Gcina Ngaphantsi kweGesi eNgangeni	Gcina Ngaphantsi kweGesi eNgangeni
Inovakalelo	Hygroscopic.Ubunobuzaza bokufuma, Bunobuzaza bubushushu
Ukunyibilika kwamanzi	Inyibilika ngokupheleleyo emanzini
Ukunyibilika	Inyibilika kwiDimethylformamide, utywala
Ugcino Temp.	Indawo epholileyo neyomileyo (<5℃)
I-COA kunye ne-MSDS	Iyafumaneka
Udidi	Coupling Reagents
Uphawu	Ruifu Chemical

Iinkcukacha:

Izinto	ImiGangatho yokuHlola	Iziphumo
Imbonakalo	Umgubo weCrystalline oMhlophe	Iyahambelana
Indawo yokunyibilika	110.0 ~ 115.0℃	112.0 ~ 114.0℃
Amanzi nguKarl Fischer	<0.50%	0.10%
Intsalela kwi-Ignition	<0.10%	0.04%
Ubunyulu (Argentmetric Titration)	>99.0%	99.70%
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)	Iyahambelana
I-Infrared Spectrum	Iyahambelana neSakhiwo	Iyahambelana
Ukunyibilika kwi-H2O (100 mg/mL)	Ayinambala ukuya kuMthubi Kakhulu, Icacile	Dlula
Ukuqukumbela	Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo

Ukupakishwa/uGcino/Ukuhambisa ngenqanawe:

Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Ukungenwa kukufuma.Gcina kwizikhongozeli ezivaliweyo kwindawo yokugcina impahla epholileyo neyomileyo (<5℃) kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.

Indlela yoVavanyo:

Iipropati: Le mveliso ngumgubo omhlophe wekristale.
2. Ukumiselwa komxholo:
2.1 Izixhobo kunye ne-reagents: i-potentiometric titrator, isisombululo se-nitric acid (12.5 wt%), isisombululo esiqhelekileyo se-AgNO3 (0.1mol / L)
2.2 Ukulungiswa kunye nokusebenza kwesampula:
I-200 ukuya kwi-220mg yachithwa kwi-40ml yamanzi adibeneyo, kwaye emva kokuba i-5ml yesisombululo se-nitric acid yongezwa, isisombululo sachithwa nge-nitrate yesilivere.
Ulwelo lwathi titthiwe ukuya kwindawo yokugqibela.Ifomula yokubala umxholo wemveliso ngolu hlobo lulandelayo:
X = (VAgNO3*19.171)/W,
X- Ipesenti ye-EDC.HCl, 100%.
V-Umthamo osetyenziswe sisisombululo esiqhelekileyo se-AgNO3, ml
I-19.171-1ml isisombululo esiqhelekileyo se-AgNO3 (0.1mol / L) idliwe ubunzima be-EDC.HCl, mg;
W - isampuli ubunzima, mg;
Indlela yenziwe kathathu ngokuhambelana kwaye i-avareji ithathwe, kwaye impazamo akufanele idlule i-0.3%.Umxholo wemveliso kufuneka ube> 99.0%.
3. Indawo yokunyibilika: ngokwendlela yokumisela i-melting point (Isihlomelo VII C se-Chinese Pharmacopoeia 2010 edition), indawo yokunyibilika yale mveliso kufuneka ibe yi-110.0 ~ 115.0℃.
4. Ukuzimisela komxholo wamanzi: ngokwendlela yokulinganisa ukufuma (indlela ye-KF) ukumisela, umxholo wamanzi wale mveliso kufuneka ube <0.50%.
5. Ukugcinwa: Gcina kwindawo emnyama nepholileyo eyomileyo (<5℃).
6. Ixesha lokuphonononga: unyaka omnye

Indlela Yokwenziwa:

Izinto eziluncedo:

Umthamo owaneleyo: Izixhobo ezaneleyo kunye namagcisa

Inkonzo yobuNgcali: Inkonzo enye yokuyeka ukuthenga

Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

Inkonzo yesiNtu yoHlanganiso: Isuka kwiigram ukuya kwiikhilos

Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.

Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.

Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.

UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.

Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.

Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.

MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.

Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.

Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.

Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.

Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.

Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.

25952-53-8 - Umngcipheko kunye noKhuseleko:

Iikhowudi zoMngcipheko
I-R34 - Ibangela ukutsha
R36/37/38 - Ukucaphukisa emehlweni, inkqubo yokuphefumla kunye nolusu.
R41 - Umngcipheko womonakalo omkhulu emehlweni
I-R37/38 - Iyacaphukisa inkqubo yokuphefumla kunye nolusu.
I-R20/21/22 - Iyingozi ngokuphefumla, xa udibana nolusu naxa uginyiwe.
Inkcazelo yoKhuseleko
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S36/37/39 - Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo / ubuso.
S45 - Kwimeko yengozi okanye ukuba uziva ungaphilanga, funa ingcebiso kagqirha ngokukhawuleza (bonisa ileyibhile nanini na kunokwenzeka.)
I-S37/39 - Nxiba iiglavu ezifanelekileyo kunye nokukhusela amehlo / ubuso
S36 - Nxiba iimpahla ezifanelekileyo zokukhusela.
Ii-ID ze-UN UN 2735 8/PG 3
WGK eJamani 3
RTECS FF2200000
FLUKA BRAND F IIKHOWUDI 1-3-10
TSCA Y
Ikhowudi yeHS 2925290090
I-Hazard Note irritant
Ubuthi LD50 emithanjeni kwimpuku: 56mg/kg

Isicelo:

I-1-(3-Dimethylaminopropyl) -3-Ethylcarbodiimide Hydrochloride (EDC · HCl) (CAS: 25952-53-8) i-crystalline powder emhlophe, i-deliquescent ngokulula, i-soluble emanzini, i-soluble kwi-ethanol, isetyenziswe njenge-activating reagent ye-carboxyl. amaqela kwi-amide synthesis, ekwasetyenziselwa ukwenza amaqela e-phosphate asebenze, i-cross-linking of proteins kunye ne-nucleic acids, kunye nokuveliswa kwe-immunocouplers.I-EDC-HCl isetyenziswe kwi-pH ye-4.0-6.0 kwaye isetyenziswa rhoqo kunye ne-N-Hydroxysuccinimide (NHS) okanye i-N-Hydroxysulfosuccinimide ityuwa ye-sodium ukuphucula ukudibanisa ukusebenza kakuhle.
I-EDC·HCl yi-water-soluble carbodiimide, isetyenziswa kakhulu ukudibanisa i-peptide.EDC·HCl isetyenziswa njenge arhente carboxyl activating.Idlala indima ebalulekileyo yokunyanzeliswa kwee-biomolecules ezinkulu ngokubambisana ne-N-hydroxysuccinimide.Ikwasetyenziswa kwi-acylation ye-phosphoranes.
Iphuma kwi-carbodiimide enyibilikayo emanzini iluncedo ekudibaniseni ihaptens kwiiproteni kunye neepolypeptides.Isetyenziselwa ukuguqula ii-receptors ze-NMDA kunye ne-arhente edibanisayo kwi-peptide synthesis.Inzuzo enkulu yokudibanisa kwe-EDAC kukususwa ngokulula kwe-reagent engaphezulu kunye ne-urea ehambelanayo ngokuhlamba nge-asidi edibeneyo okanye amanzi.I-Carbodiimides ibangela ukubunjwa kwee-amide bond, i-carboxylic acids, kunye ne-amines ngokuvula i-carboxylate ukwenza i-O-acylurea.Esi siphakathi sinokuhlaselwa yi-amine ngokuthe ngqo ukwenza i-amide.I-EDAC ikhutshwa njengento ephuma kwi-urea enyibilikayo.
I-EDC · I-HCl ingasetyenziselwa ukuhlanganiswa kwee-amides.Isetyenziswe njenge-agent yokudibanisa kwi-synthesis ye-esters esuka kwi-carboxylic acids isebenzisa i-dimethylaminopyridine njenge-catalyst.
Kukho ubukhulu becala zintathu ii-agent zokujiya eziqhele ukusetyenziswa: DCC, DIC kunye neEDC·HCl.Ukusetyenziswa kolu hlobo lwe-arhente yokunciphisa ngokubanzi kufuna ukongezwa kwe-acylation catalysts okanye i-activators, njenge-DMAP, i-HOBt, njl njl. I-catalyst ayisetyenziselwa ukuyiguqula ibe yi-ester esebenzayo esebenzayo okanye i-amide esebenzayo, iya kuphinda iphinde ihlelwe kwimveliso ehambelanayo ne-urea (iNdlela B).I-activator yecondensation: Kukho ezi ndidi zilandelayo ze-condensation activator esetyenziswa ngokuqhelekileyo.Okwangoku, i-4-N, i-N-dimethylpyridine (i-DMAP) isetyenziswe ngokubanzi ukukhupha iimpendulo ezahlukeneyo ze-acylation.Ngamanye amaxesha i-4-PPY ingasetyenziswa xa i-catalytic effect ye-DMAP ingalunganga.Ngokoncwadi olufanelekileyo, isakhono sayo sobuchule simalunga newaka lamaxesha aphezulu kune-DMAP.phakathi kweecondensers ezintathu ezisetyenziswa ngokuqhelekileyo, iDCC kunye neDIC zitshiphu.Ngokubanzi iDCC kunye neDMAP zisetyenziswa kunye.Enye yezona zinto zingalunganga kakhulu ekusebenziseni i-DCC kukuba enye imveliso ye-reaction, i-dicyclohexylurea, ine-solubility encinci kwisigaba sezinto eziphilayo kodwa i-soluble kancinane, ngoko ke kunzima ukuyisusa ngokucokisekileyo ngeendlela ezisetyenziswa ngokuqhelekileyo zokucoca, i-recrystallization. ikholam yechromatography, njl.;ngenxa yokuba ukunyibilika kwe-dicyclohexylurea kwi-ether kuncinci kunezinye izinyibilikisi, ke ngoko, unyango lolu hlobo lokusabela luba ngumphunga ngokubanzi kwi-solvent yokusabela kwaye yongeze i-ether, kwaye ihluze ngaphandle uninzi lwe-dicyclohexylurea ngaphambi konyango olongezelelweyo.Ngenxa yokuba i-diisopropylurea eveliswe yi-DIC ine-solubility engcono kwi-solvents jikelele ye-organic, idla ngokusetyenziswa kwi-combinatorial chemistry solid-phase synthesis.I-EDCI okwangoku isetyenziswa kakhulu kwikhemistry yezonyango.Enye yeempawu zayo eziphambili kukuba i-urea eyenziwe emva kokusabela i-soluble yamanzi kwaye kulula ukuyihlamba.Ngokubanzi, i-EDCI idityaniswe ne-HOBt (qaphela: le ndlela yokusabela i-HOBt iyimfuneko ngokubanzi, kungenjalo inokukhokelela kwisivuno esisezantsi kakhulu soxinaniso).Ngamanye amaxesha ukuba indawo yokuthintela i-asidi inkulu okanye kukho iqela lokurhoxisa i-electron, i-reaction iya kuhlala kwinqanaba le-ester esebenzayo (i-ester esebenzayo inomqondiso oqinileyo we-mass spectrum kwaye inokubonwa yi-MS okanye i-LC-MS).