I-Entecavir Monohydrate CAS 209216-23-9 API Factory High Quality Antiviral Hepatitis B Infection

Inkcazelo emfutshane:

Igama leKhemikhali: Entecavir Monohydrate

CAS: 209216-23-9

Imbonakalo: Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe

Iyeza elilwa nentsholongwane esetyenziswa kunyango lwe-Hepatitis B Usulelo

Umgangatho ophezulu we-API, iMveliso yoRhwebo

Inquiry: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ubonelelo lwabavelisi ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leKhemikhali: Entecavir Monohydrate
CAS: 209216-23-9
Isetyenziswe kunyango lwe-Hepatitis B Infection
Umgangatho ophezulu we-API, iMveliso yoRhwebo

Iipropati zeMichiza:

Igama leMchiza	Entecavir Monohydrate
Izithethantonye	I-Entecavir Hydrate;9 - [(1S,3R,4S) -4-Hydroxy-3-(hydroxymethyl) -2-methylenecyclopentyl]guanine Monohydrate
Inombolo yeCAS	209216-23-9
Inombolo yeCAT	RF-API79
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram
Ifomula yeemolekyuli	C12H17N5O4
Ubunzima beMolekyuli	295.3
Indawo yokunyibilika	>220℃
Ukuxinana	1.81
Imeko yokuthumela ngenqanawa	Ithunyelwe Ngaphantsi Kweqondo Lobushushu Le-Ambient
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe
Ukunyibilika	Inyibilika ngokukhululekileyo kwiDimethylformamide, iNyibilika kancinane emanzini, iEthanol kunye neMethanol
Ukuchongwa kwe-IR	I-Spectrum yesampuli ihambelana naleyo yomgangatho wereferensi
Ukuchongwa kwe-HPLC	Ixesha lokugcinwa kwesampulu yovavanyo lihambelana nelo lomgangatho wereferensi
Isiqulatho samanzi (nge-KF)	5.5%~6.5%
Ujikelezo oluKhethekileyo lwe-Optical	+24.0° ukuya +30.0° (DMF: MeOH=1:1 C=1%) (kwinto engenamanzi)
Intsalela kwi-Ignition	≤0.10%
Izinto ezinxulumeneyo
I-Furoentecavir	≤0.10%
I-Entecavir 1-Epimer	≤0.10%
Entecavir 3-Epimer	≤0.10%
8-Methyoxy Entecavir	≤0.10%
Entecavir 4-Epimer	≤0.10%
I-8-Hydroxy Entecavir	≤0.10%
I-4-Dimethylsilyl Entecavir	≤0.10%
I-Entecavir eNxulumene nayo iCompound A	≤0.10%
Nakuphi na Ukungcola Okungachazwanga	≤0.10%
Ukungcola ngokupheleleyo	≤0.30%
Izinyibilikisi ezishiyekileyo
IMethanol	≤600ppm
Dichloromethane	≤300ppm
I-Ethyl Acetate	≤1000ppm
Tetrahydrofuran	≤720ppm
Toluene	≤890ppm
Ibenzyl chloride	≤1000ppm
Utywala beBenzyl	≤1000ppm
Umda weMicrobial
Ubalo lweAerobic iyonke	≤100cfu/g
Igwele kunye nokungunda	≤10cfu/g
Escherichia Coli	Akufunekanga Ibhaqwe
Iintsimbi ezinzima	≤10ppm
Isivavanyi	98.0% ~ 102.0% (HPLC; kwisiseko se-anhydrous)
Ubungakanani beNcam	I-95% yamaqhekeza kufuneka ibe ngaphakathi kwe-125um
Umgangatho woVavanyo	uMgangatho woShishino;Umgangatho we-United States Pharmacopoeia (USP).
Ukusetyenziswa	Iyeza elilwa nentsholongwane esetyenziswa kunyango lwe-Hepatitis B Usulelo

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

Izinto eziluncedo:

FAQ:

Isicelo:

I-Entecavir Monohydrate (i-CAS 209216-23-9) sisiyobisi somlomo esisetyenziselwa unyango lwe-Hepatitis B Virus (HBV) usulelo.I-Entecavir Monohydrate yi-analog ye-nucleoside (ngokukodwa, i-guanine analogue) inqanda ukubhalwa kwe-reverse, ukuphindaphinda kwe-DNA kunye nokubhalwa kwi-vira.Luhlobo olutsha lwe-cyclopentyl acyl guanosine anti-Hepatitis B virus yeziyobisi kunye neziphumo zayo ze-pharmacological ezifana ne-Entecavir.Isetyenziswa ngokweklinikhi kunyango lwe-Hepatitis B engapheliyo apho kukho ukuphindaphinda kwentsholongwane esebenzayo, ukwanda kwe-serum transaminase ALT okanye izilonda ezisebenzayo eziboniswe kwi-histology yesibindi.I-Entecavir Monohydrate inamandla kwaye i-inhibitor ekhethiweyo ye-HBV, kunye ne-EC50 ye-3.75 nM kwi-HepG2 iseli.I-Entecavir yi-reverse transcriptase inhibitor.Ikhusela i-Hepatitis B Virus (HBV) ekuziphindaphindeni kwaye inciphisa umthamo wentsholongwane emzimbeni.