I-Entecavir Monohydrate CAS 209216-23-9 API Factory High Quality Antiviral Hepatitis B Infection
Ubonelelo lwabavelisi ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leKhemikhali: Entecavir Monohydrate
CAS: 209216-23-9
Isetyenziswe kunyango lwe-Hepatitis B Infection
Umgangatho ophezulu we-API, iMveliso yoRhwebo
Igama leMchiza | Entecavir Monohydrate |
Izithethantonye | I-Entecavir Hydrate;9 - [(1S,3R,4S) -4-Hydroxy-3-(hydroxymethyl) -2-methylenecyclopentyl]guanine Monohydrate |
Inombolo yeCAS | 209216-23-9 |
Inombolo yeCAT | RF-API79 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
Ifomula yeemolekyuli | C12H17N5O4 |
Ubunzima beMolekyuli | 295.3 |
Indawo yokunyibilika | >220℃ |
Ukuxinana | 1.81 |
Imeko yokuthumela ngenqanawa | Ithunyelwe Ngaphantsi Kweqondo Lobushushu Le-Ambient |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe |
Ukunyibilika | Inyibilika ngokukhululekileyo kwiDimethylformamide, iNyibilika kancinane emanzini, iEthanol kunye neMethanol |
Ukuchongwa kwe-IR | I-Spectrum yesampuli ihambelana naleyo yomgangatho wereferensi |
Ukuchongwa kwe-HPLC | Ixesha lokugcinwa kwesampulu yovavanyo lihambelana nelo lomgangatho wereferensi |
Isiqulatho samanzi (nge-KF) | 5.5%~6.5% |
Ujikelezo oluKhethekileyo lwe-Optical | +24.0° ukuya +30.0° (DMF: MeOH=1:1 C=1%) (kwinto engenamanzi) |
Intsalela kwi-Ignition | ≤0.10% |
Izinto ezinxulumeneyo | |
I-Furoentecavir | ≤0.10% |
I-Entecavir 1-Epimer | ≤0.10% |
Entecavir 3-Epimer | ≤0.10% |
8-Methyoxy Entecavir | ≤0.10% |
Entecavir 4-Epimer | ≤0.10% |
I-8-Hydroxy Entecavir | ≤0.10% |
I-4-Dimethylsilyl Entecavir | ≤0.10% |
I-Entecavir eNxulumene nayo iCompound A | ≤0.10% |
Nakuphi na Ukungcola Okungachazwanga | ≤0.10% |
Ukungcola ngokupheleleyo | ≤0.30% |
Izinyibilikisi ezishiyekileyo | |
IMethanol | ≤600ppm |
Dichloromethane | ≤300ppm |
I-Ethyl Acetate | ≤1000ppm |
Tetrahydrofuran | ≤720ppm |
Toluene | ≤890ppm |
Ibenzyl chloride | ≤1000ppm |
Utywala beBenzyl | ≤1000ppm |
Umda weMicrobial | |
Ubalo lweAerobic iyonke | ≤100cfu/g |
Igwele kunye nokungunda | ≤10cfu/g |
Escherichia Coli | Akufunekanga Ibhaqwe |
Iintsimbi ezinzima | ≤10ppm |
Isivavanyi | 98.0% ~ 102.0% (HPLC; kwisiseko se-anhydrous) |
Ubungakanani beNcam | I-95% yamaqhekeza kufuneka ibe ngaphakathi kwe-125um |
Umgangatho woVavanyo | uMgangatho woShishino;Umgangatho we-United States Pharmacopoeia (USP). |
Ukusetyenziswa | Iyeza elilwa nentsholongwane esetyenziswa kunyango lwe-Hepatitis B Usulelo |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
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I-Entecavir Monohydrate (i-CAS 209216-23-9) sisiyobisi somlomo esisetyenziselwa unyango lwe-Hepatitis B Virus (HBV) usulelo.I-Entecavir Monohydrate yi-analog ye-nucleoside (ngokukodwa, i-guanine analogue) inqanda ukubhalwa kwe-reverse, ukuphindaphinda kwe-DNA kunye nokubhalwa kwi-vira.Luhlobo olutsha lwe-cyclopentyl acyl guanosine anti-Hepatitis B virus yeziyobisi kunye neziphumo zayo ze-pharmacological ezifana ne-Entecavir.Isetyenziswa ngokweklinikhi kunyango lwe-Hepatitis B engapheliyo apho kukho ukuphindaphinda kwentsholongwane esebenzayo, ukwanda kwe-serum transaminase ALT okanye izilonda ezisebenzayo eziboniswe kwi-histology yesibindi.I-Entecavir Monohydrate inamandla kwaye i-inhibitor ekhethiweyo ye-HBV, kunye ne-EC50 ye-3.75 nM kwi-HepG2 iseli.I-Entecavir yi-reverse transcriptase inhibitor.Ikhusela i-Hepatitis B Virus (HBV) ekuziphindaphindeni kwaye inciphisa umthamo wentsholongwane emzimbeni.
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