I-Erlotinib Hydrochloride CAS 183319-69-9 Ubunyulu > 99.0% (HPLC)

Inkcazelo emfutshane:

Igama leMichiza: I-Erlotinib Hydrochloride

Izithethantonye: Erlotinib HCl;Tarceva

CAS: 183319-69-9

Ubunyulu (HPLC): >99.0%

Imbonakalo: Mhlophe ukuya kuMhlophe-Mhlophe wePowder

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Umvelisi ohamba phambili kunye nomthengisi we-Erlotinib Hydrochloride Intermediates
I-Erlotinib Hydrochloride CAS 183319-69-9
3-Ethynylaniline CAS 54060-30-9
6,7-Bis (2-Methoxyethoxy)-3H-Quinazolin-4-enye CAS 179688-29-0
Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	I-Erlotinib Hydrochloride
Izithethantonye	I-Erlotinib HCl;Tarceva;CP-358774 Hydrochloride;I-6,7-Bis (2-methoxyethoxy) -4- (3-ethynylanilino) i-quinazoline Hydrochloride;N-(3-Ethynylphe nyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine HCl
Inombolo yeCAS	183319-69-9
Inombolo yeCAT	RF-PI2242
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C22H24ClN3O4
Ubunzima beMolekyuli	429.90
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kuMhlophe oMhlophe wePowder
Ukuchongwa	A: IR: Ihambelana neSpectrum yeReferensi B: I-HPLC: Ihambelana ne-Reference RT
Ukunyibilika	Inyibilika kancinane kakhulu emanzini, iNyibilika kancinane kwiMethanol kwaye ayiNyibiliki ngokweAcetonitrile, iAcetone, iEthyl acetate kunye neHexane
Indawo yokunyibilika	223.0 ~ 229.0℃
Ilahleko ekomisweni	<0.50%
Intsalela kwi-Ignition	<0.20%
Iintsimbi ezinzima	<20ppm
Ukungacoceki Okukodwa	<0.50%
Ukungcola ngokupheleleyo	<1.00%
Izinyibilikisi ezishiyekileyo
I-Pyridine	<4000ppm
I-Chloroform	<4000ppm
I-DMF	<3000ppm
Ubunyulu / Indlela yokuHlalutya	>99.0%
Indlela yoVavanyo / yoHlahlelo	98.5% ~ 101.0% (Ibalwe kwiSiseko esingenamanzi)
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	API

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

I-Erlotinib Hydrochloride (CAS: 183319-69-9) yimolekyuli encinci ye-epidermal growth factor receptor tyrosine kinase reversible inhibitor, isetyenziswa ikakhulu kunyango lomhlaza wemiphunga weseli ohamba phambili okanye we-metastatic ongewona omncinci weseli kunye nomgca wesibini okanye unyango lwemigca emithathu. umhlaza wepancreatic.I-Erlotinib Hydrochloride yamkelwa ngoNovemba, 2004, kunyango lomhlaza wemiphunga ophezulu okanye we-metastatic ongeyonxalenye encinci.Kukwiklasi efanayo ne-Gefitinib, enye i-quinazoline evunyiweyo kunyango lomhlaza wemiphunga ophezulu, kodwa ngeempawu eziphuculweyo ze-pharmacokinetic.I-molecule yaqalwa nguPfizer kwaye uphuhliso lwaqalwa ngokubambisana ne-OSI, eyathatha amalungelo apheleleyo kwichiza xa iPfizer idityaniswa noWarner Lambert.Emva koko, i-Genentech/Roche yangena kwisivumelwano selayisensi ne-OSI ukuphuhlisa nokuthengisa ichiza e-US nakwihlabathi liphela.I-epidermal growth factor receptor ekhethiweyo (EGFR) -tyrosine kinase inhibitor.I-Antineoplastic.I-Erlotinib Hydrochloride yi-HER1/EGFR inhibitor ene-IC50 ye-2 nM.I-Erlotinib HCl ifumaneka njenge-25-, 100-, kunye ne-150-mg iipilisi zolawulo lomlomo.