I-Ethyl (S)-4-Chloro-3-hydroxybutyrate CAS 86728-85-0 Atorvastatin Calcium Intermediate
![10](https://www.ruifuchemical.com/uploads/102.jpg)
Igama leMchiza | I-Ethyl (S) -4-Chloro-3-hydroxybutyrate |
Izithethantonye | (S) -4-Chloro-3-hydroxybutyric Acid Ethyl Ester |
Inombolo yeCAS | 86728-85-0 |
Inombolo yeCAT | RF-PI139 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C6H11ClO3 |
Ubunzima beMolekyuli | 166.6 |
Ukuxinana | 1.19 g/mL ku-25℃ (lit.) |
Refractive Index | n20/D 1.453 (lit.) |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | AbunaMbala ukuya kuLulwelo oluMthubi |
Ubunyulu / Indlela yokuHlalutya | ≥98.0% (GC) |
Ukufuma (KF) | ≤0.50% |
Ethyl-4-Chloro Aceto Acetate | ≤0.50% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Phakathi kwezamayeza;I-Organic Synthesis |
I-Ethyl (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0)
Indlela yokuhlalutya
Inkcazo
Thatha malunga ne-10ml isampuli kwipleyiti yeglasi ecocekileyo neyomileyo kwaye ukhangele.
Ukujikeleza okuthe ngqo
Dlulisa ngokuchanekileyo malunga ne-1.0g yesampuli ukuya kwi-100ml yeflask yevolumetric kwaye inyibilikisweI-10 ml ye-chloroform, uze uhlambulule nge-chloroform kwi-100ml kwaye udibanise.
Linganisa ukujikeleza kwamehlo kwisampulu yovavanyo kwi-25ºC kunye ne-589nm wavelengthbala ujikelo oluthile ngokwefomula enikiweyo.
[α]25D = (v×a)/[w×(1-b)]
[α]25D: ujikelezo oluthile lovavanyoisampuli;α: ujikelezo olujongiweyo kwiiqondo le-angular;w: ubunzima besampulu (g);
v: umthamo (mL);
b: Isiqulatho samanzi(%)
Ucoceko (ngu GC)
Iimeko zeChromatographic: Ichromatography yegesi ixhotyiswe ngedangatyeumtshini we-ionization
Uluhlu: SE-54, 30m×0.35mm×0.25µm
Ubushushu be-oveni: Ubushushu bokuqala 120℃, Bamba ixesha le-2min
Irempu: 20℃/min
Temp: 250℃, Bamba ixesha 2min
Ubushushu be-injector: 250℃
Ubushushu besixhobo: 250℃(FID)
Umthamo wokutofa: 0.2µl
Isisombululo sesampuli: nciphisa i-1ml A4 kunye ne-1ml ye-acetone.
Inkqubo: Tofa i-0.2µl ye-acetone njengengenanto kwaye urekhode ichromatogram.KwiIchromatogram efunyenwe kwi-diluent akufuneki kubekho luphazamiso kwiixesha lokugcinwa kwencopho ephambili kunye nencopho yokungcola.KunokuTofa isisombululo sesampuluphinda kwichromatograph kwaye urekhode ichromatogram.Xela ubunyulu beisampuli ngokwendlela yokwenziwa kwesiqhelo kwendawo.
Iphakheji: Ibhotile, umgqomo, 25kg / umphanda, okanye ngokwemfuno umthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
![2](https://www.ruifuchemical.com/uploads/23.jpg)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we-Ethyl (S) -4-Chloro-3-hydroxybutyrate (i-CAS: 86728-85-0) enomgangatho ophezulu, iphakathi ngokuqhelekileyo kwi-synthesis ye-Atorvastatin. Calcium (CAS: 134523-03-8).
I-Atorvastatin Calcium (i-CAS: 134523-03-8) [igama lokuthengisa: I-Lipitor] ibonakaliswe ngokukodwa kunyango lwe-cardiovascular disease kunye ne-dyslipidemia ngenxa yempembelelo yayo ekunciphiseni i-cholesterol egazini.I-Atorvastatin isebenza ikakhulu esibindini.Ukunciphisa amanqanaba e-cholesterol esibindini kwandisa ukwanda kwe-cholesterol kwaye kunciphisa amanqanaba e-cholesterol kwiplasma.ILipitor, ukusukela ngo-1996, iye yaba lelona yeza lithengiswa kakhulu kwihlabathi ukuza kuthi ga ngoku.
-
(S)-(-)-4-Chloro-3-Hydroxybutyronitrile CAS 127...
-
I-Ethyl (S)-4-Chloro-3-hydroxybutyrate CAS 86728-...
-
Methyl Isobutyrylacetate IBEM CAS 42558-54-3 Pu...
-
ATS-8 Atorvastatin Calcium Intermediate CAS 125...
-
ATS-9 Atorvastatin Calcium Intermediate CAS 125...
-
Atorvastatin Calcium Intermediate M-4 CAS 12597...
-
Atorvastatin Acetonide tert-Butyl Ester CAS 125...
-
Atorvastatin tert-Butyl Ester CAS 134395-00-9 A...