I-Ethyl (S)-4-Chloro-3-hydroxybutyrate CAS 86728-85-0 Atorvastatin Calcium Intermediate

Inkcazelo emfutshane:

Igama leKhemikhali: I-Ethyl (S) -4-Chloro-3-hydroxybutyrate

CAS: 86728-85-0

Imbonakalo: AyinaMbala ukuya kuLulwelo oluMthubi

Ubunyulu: ≥98.0% (GC)

Umbindi weAtorvastatin Calcium (CAS: 134523-03-8)

Inquiry: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

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Inkcazo:

Iipropati zeMichiza:

Igama leMchiza	I-Ethyl (S) -4-Chloro-3-hydroxybutyrate
Izithethantonye	(S) -4-Chloro-3-hydroxybutyric Acid Ethyl Ester
Inombolo yeCAS	86728-85-0
Inombolo yeCAT	RF-PI139
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C6H11ClO3
Ubunzima beMolekyuli	166.6
Ukuxinana	1.19 g/mL ku-25℃ (lit.)
Refractive Index	n20/D 1.453 (lit.)
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	AbunaMbala ukuya kuLulwelo oluMthubi
Ubunyulu / Indlela yokuHlalutya	≥98.0% (GC)
Ukufuma (KF)	≤0.50%
Ethyl-4-Chloro Aceto Acetate	≤0.50%
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Phakathi kwezamayeza;I-Organic Synthesis

I-Ethyl (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0)
Indlela yokuhlalutya
Inkcazo
Thatha malunga ne-10ml isampuli kwipleyiti yeglasi ecocekileyo neyomileyo kwaye ukhangele.
Ukujikeleza okuthe ngqo
Dlulisa ngokuchanekileyo malunga ne-1.0g yesampuli ukuya kwi-100ml yeflask yevolumetric kwaye inyibilikisweI-10 ml ye-chloroform, uze uhlambulule nge-chloroform kwi-100ml kwaye udibanise.
Linganisa ukujikeleza kwamehlo kwisampulu yovavanyo kwi-25ºC kunye ne-589nm wavelengthbala ujikelo oluthile ngokwefomula enikiweyo.
[α]25D = (v×a)/[w×(1-b)]
[α]25D: ujikelezo oluthile lovavanyoisampuli;α: ujikelezo olujongiweyo kwiiqondo le-angular;w: ubunzima besampulu (g);
v: umthamo (mL);
b: Isiqulatho samanzi(%)
Ucoceko (ngu GC)
Iimeko zeChromatographic: Ichromatography yegesi ixhotyiswe ngedangatyeumtshini we-ionization
Uluhlu: SE-54, 30m×0.35mm×0.25µm
Ubushushu be-oveni: Ubushushu bokuqala 120℃, Bamba ixesha le-2min
Irempu: 20℃/min
Temp: 250℃, Bamba ixesha 2min
Ubushushu be-injector: 250℃
Ubushushu besixhobo: 250℃(FID)
Umthamo wokutofa: 0.2µl
Isisombululo sesampuli: nciphisa i-1ml A4 kunye ne-1ml ye-acetone.
Inkqubo: Tofa i-0.2µl ye-acetone njengengenanto kwaye urekhode ichromatogram.KwiIchromatogram efunyenwe kwi-diluent akufuneki kubekho luphazamiso kwiixesha lokugcinwa kwencopho ephambili kunye nencopho yokungcola.KunokuTofa isisombululo sesampuluphinda kwichromatograph kwaye urekhode ichromatogram.Xela ubunyulu beisampuli ngokwendlela yokwenziwa kwesiqhelo kwendawo.

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, umgqomo, 25kg / umphanda, okanye ngokwemfuno umthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

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FAQ:

Isicelo:

I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we-Ethyl (S) -4-Chloro-3-hydroxybutyrate (i-CAS: 86728-85-0) enomgangatho ophezulu, iphakathi ngokuqhelekileyo kwi-synthesis ye-Atorvastatin. Calcium (CAS: 134523-03-8).

I-Atorvastatin Calcium (i-CAS: 134523-03-8) [igama lokuthengisa: I-Lipitor] ibonakaliswe ngokukodwa kunyango lwe-cardiovascular disease kunye ne-dyslipidemia ngenxa yempembelelo yayo ekunciphiseni i-cholesterol egazini.I-Atorvastatin isebenza ikakhulu esibindini.Ukunciphisa amanqanaba e-cholesterol esibindini kwandisa ukwanda kwe-cholesterol kwaye kunciphisa amanqanaba e-cholesterol kwiplasma.ILipitor, ukusukela ngo-1996, iye yaba lelona yeza lithengiswa kakhulu kwihlabathi ukuza kuthi ga ngoku.