Etravirine TMC-125 CAS 269055-15-4 Assay ≥99.0% (HPLC) API Factory High Purity
Umenzi onobunyulu obuPhezulu kunye noMgangatho oZinzile
Igama leKhemikhali: Etravirine (TMC-125)
CAS: 269055-15-4
Umgangatho ophezulu we-API, iMveliso yoRhwebo
Igama leMchiza | Etravirine |
Izithethantonye | TMC-125 |
Inombolo yeCAS | 269055-15-4 |
Inombolo yeCAT | RF-API54 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C20H15BrN6O |
Ubunzima beMolekyuli | 435.28 |
Ukuxinana | 1.439 g/cm3 |
Imeko yokuthumela ngenqanawa | Phantsi koBubushushu be-Ambient |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oqinileyo oMhlophe |
Ukuchongwa | Ngo-IR, HPLC |
Indawo yokunyibilika | 211.0 ~ 216.0℃ |
Isiqulatho samanzi | ≤0.50% |
Intsalela kwi-Ignition | ≤0.20% |
Iintsimbi ezinzima | ≤20ppm |
Nakuphi na Ukungacoceki Okukodwa | ≤0.50% |
Ukungcola ngokupheleleyo | ≤1.0% |
Isivavanyi | ≥99.0% (HPLC) |
Umgangatho woVavanyo | Umgangatho woShishino |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Etravirine (TMC-125) (CAS 269055-15-4) sisizukulwana sesibini i-non-nucleoside reverse transcriptase inhibitor (NNRTI) esetyenziselwa unyango lwe-HIV.Iboniswa ukuba isetyenziswe ngokudityaniswa nezinye ii-antiretroviral agents ekunyangeni usulelo lwe-HIV-1 kwizigulane ezinamava kunyango ezinobungqina bokuphindaphinda kwentsholongwane egazini kunye ne-HIV-1 exhathisayo kwii-NNRTIs ezikhoyo ngoku kunye nezinye ii-antiretroviral agents.Ii-NNRTIs, kunye ne-nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs), ngamalungu abalulekileyo erejimeni ezidityanisiweyo ezisetyenziswa ngoku ukunyanga usulelo lwe-HIV-1.I-NRTIs / NtRTIs yenza ngokukhuphisana ne-nucleotide substrates yendalo ye-reverse transcriptase yokufakwa kwi-DNA yentsholongwane kunye nokupheliswa kwekhonkco elilandelayo.Ngokwahlukileyo, ii-NNRTIs zibophelela kwindawo ye-allosteric ye-enzyme kwaye iphazamise umsebenzi we-DNA polymerase ngokubangela utshintsho oluhambelanayo kwindawo ye-catalytic.