I-Fmoc-Gly-OH CAS 29022-11-5 Fmoc-Glycine Purity >99.0% (HPLC) Factory

I-Fmoc-Glycine (i-Fmoc-Gly-OH) (i-CAS: 29022-11-5) yindlela ekhuselweyo ye-N-Fmoc ye-Glycine.I-Glycine yi-amino acid engabalulekanga.I-Fmoc-amino acids, esetyenziswa kwi-peptide synthesis, esetyenziswa njenge-organic synthesis ephakathi, i-pharmaceutical intermediate, i-biochemical reagent okanye i-chemical reagent.
Intshayelelo: I-Fmoc-Glycine yiGlycine ekhuselwe yiFmoc.I-Fluorene methoxycarbonyl (i-Fmoc) liqela elikhuselayo elisisiseko, elingasetyenziselwa kumanzi e-ammonia agxininisiweyo okanye i-dioxane-methanol-4N NaOH (30: 9: 1) kunye ne-piperidine, i-ethanolamine, i-cyclohexylamine, i-1,4-Dioxane, i-pyrrolidone kunye ne-pyrrolidone. enye ammonia 50% isisombululo dichloromethane.Ngaphantsi kweemeko ze-alkaline ezibuthathaka ezifana ne-sodium carbonate okanye i-sodium bicarbonate, iqela lokukhusela i-Fmoc ngokubanzi laziswa yi-Fmoc-Cl okanye i-Fmoc-OSu.
Isicelo: I-Fmoc-Glycine yi-Fmoc-protected Glycine, esetyenziswa ikakhulu ukwenza iipolypeptides.Umahluko wamaqela okukhusela i-amino acid unempembelelo enkulu ekusebenzeni kunye nesivuno se-polypeptide synthesis.Ngokomzekelo, i-Fmoc-Glycine ingasetyenziselwa ukulungisa i-glycine derivative corrosion inhibitor, kunye neqela le-Fmoc-protecting kunye ne-hydrophobic chain chain ende ixhunywe kwi-molecule ye-Glycine ngokusebenzisa i-amidation reaction, kunye ne-heteroatom (N, O, njl.) Okanye. iibhondi ezingaxutywanga) kunye neringi ye-bisphenyl equlethe ii-electron π zibhengezwe kwisinyithi, kwaye ikhonkco elide le-hydrophobic livimba iiathomu zamanzi, ukuze zenze ifilimu ekhuselayo kumphezulu wentsimbi ukufezekisa injongo yokukhusela umhlwa.
Ukulungiselela: Amanyathelo athile e-Fmoc-Glycine synthesis alandelayo: I-3.0g Glycine ichithwe kwi-115ml ye-10% ye-Na2CO3, ipholile ukuya kwi-4 ~ 0 ℃, i-11.2g ye-Fmoc-Cl echithwe kwi-35.0ml ye-acetone kwaye yongezwa kwi-dropwise system, emva kokongeza i-dropwise, ugxobhoze kwibhafu ye-ice ye-30min, uze uvuselele kwiqondo lokushisa kwe-2.0h.Inkqubela phambili yokusabela yajongwa ngumaleko obhityileyo wechromatography.Emva kokuba impendulo igqityiwe, i-400ml yamanzi igalelwe emanzini, i-ether ikhutshwe kabini, ipholile kwaye ilungelelaniswe kwi-pH2 kunye ne-hydrochloric acid egxininisiweyo, ubuninzi obuqinileyo obumhlophe buhlanjululwe, i-50 ml ye-ethyl acetate ikhutshwe kathathu, i-magnesium anhydrous. I-sulfate yomiswa, i-solvent yachithwa phantsi koxinzelelo oluncitshisiweyo, kwaye i-petroleum ether yayisetyenziselwa ukukhawuleza ukufumana i-11.5g ye-Fmoc-Glycine.Emva kokucoca, ukucoceka kwemveliso kwakungama-97.35% ngokusebenza okuphezulu kwechromatography yolwelo.