Fmoc-Leu-OH CAS 35661-60-0 N-Fmoc-L-Leucine Purity >99.0% (HPLC) Factory
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-N-Fmoc-L-Leucine (Fmoc-Leu-OH) (i-CAS: 35661-60-0) enomgangatho ophezulu.I-Ruifu Chemical ibonelela ngothotho lweeamino acids.Sinokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, ubungakanani obuncinci kunye nobuninzi obukhoyo.Thenga iFmoc-Leu-OH,Please e-mail: alvin@ruifuchem.com
| Igama leMchiza | N-Fmoc-L-Leucine |
| Izithethantonye | Fmoc-Leu-OH;Fmoc-L-Leu-OH;Fmoc-L-Leucine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-Leucine;N-(9-Fluorenylmethoxycarbonyl)-L-Leucine |
| Ubume beStokhwe | KwiStokhwe, Umthamo weMveliso kwiiToni ngeNyanga |
| Inombolo yeCAS | 35661-60-0 |
| Ifomula yeemolekyuli | C21H23NO4 |
| Ubunzima beMolekyuli | 353.42 g/mol |
| Indawo yokunyibilika | 153.0 ukuba 160.0℃ |
| Ukuxinana | 1.207±0.06 g/cm3 |
| Inovakalelo | Hygroscopic |
| Ukunyibilika kwiMethanol | Phantse Ukungafihli |
| Ugcino Temp. | Indawo epholileyo neyomileyo (2~8℃) |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Udidi | Fmoc-Amino Acids |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Umgubo oMhlophe | Umgubo oMhlophe |
| Ukujikeleziswa okuthe ngqo [α]20/D | -25.0°±2.0° (C=1 kwiDMF) | -24.6 ° |
| Indawo yokunyibilika | 153.0 ukuba 160.0℃ | 155.1℃ |
| TLC | ≥98.0% | >98.0% |
| Ukucoceka kwamehlo | <0.30% D-Enantiomer | Iyahambelana |
| Ukucaca kwesisombululo | I-0.3 gram kwi-2ml ye-DMF ecacileyo Isisombululo | Iyahambelana |
| Uvavanyo lweKaiser | <0.05% | <0.05% |
| Amanzi nguKarl Fischer | <0.50% | 0.12% |
| Ilahleko ekomisweni | <0.50% (60℃, 2h) | 0.15% |
| Fmoc-β-Ala-OH | <0.20% (HPLC) | Iyahambelana |
| Fmoc-β-Ala-Leu-OH | <0.10% (HPLC) | Iyahambelana |
| Fmoc-Leu-Leu-OH | <0.10% (HPLC) | Iyahambelana |
| Fmoc-Ile-OH | <0.10% (HPLC) | Iyahambelana |
| Isilingo sasimahla seAmino Acid | <0.20% (GC) | Iyahambelana |
| I-Ethyl Acetate | <0.50% (GC) | Iyahambelana |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) | 99.85% |
| Ubuninzi beSpectrum | Ngokungqinelana noMgangatho | Iyahambelana |
| NMR Spectrum | Ngokungqinelana noMgangatho | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha | |
Iphakheji: Ibhotile eFluorinated, iAluminium foil bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo yokugcina impahla epholileyo neyomileyo (2~8℃) kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Inkqubo yokuhlola
1. Imbonakalo
-- Ukuhlolwa okubonakalayo
2. Ubunyulu (HPLC)
2.1 Isixhobo
Ukusebenza okuphezulu kwechromatography yolwelo, umtshina wePDA.
Ibhalansi yohlalutyo lwe-elektroniki
2.2 I-Reagent
I-Acetonitrile (ibakala le-chromatographic), i-Trifluoroacetic acid (ibakala le-chromatographic)
2.3 Iimeko zeChromatographic
2.3.1 Umhlathi: YMC-ODS-AM, 5μL, 250x4.6 mm
2.3.2 Ubungakanani bewavenge: INC220nm
Izinga lokuhamba: 1.0mL / min
Ubungakanani besampulu: 10μL (ireferensi)
Ukunciphisa: i-acetonitrile
Ixesha lokuqokelela idatha: 25.00min
2.4 Ukulungiswa kwesigaba esiphathwayo
Isigaba se-Mobile A (i-0.1% yamanzi e-trifluoroacetic acid): ukufunxa ngokuchanekileyo i-2.0ml i-trifluoroacetic acid, ihlanjululwe ngamanzi ukuya kwi-2000ml, xuba kakuhle, kunye ne-degassing;
Isigaba se-Mobile B (i-0.1% i-acetonitrile trifluoroacetic acid): ifunxa ngokuchanekileyo i-2.0ml i-trifluoroacetic acid, ihlanjululwe kwi-2000ml nge-acetonitrile, ukuxuba kunye ne-degassing;
Ixesha (umzu) A% B%
0.00 90 10
13.00 10 90
18.00 10 90
18.01 90 10
23.00 90 10
2.6 Ukulungiswa kwesisombululo sesampuli
Ubunzima kwaye uchithe isampuli ye-0.1g kunye ne-acetonitrile kwaye udibanise kwi-100ml, xubha kakuhle ukusetyenziswa, okanye ugxininiso olufanayo.Lungiselela iisampuli ezimbini ngokuhambelanayo.
2.7 Ukumiselwa kweSampuli
Hlalutya isampuli ngokwenkqubo yesampulu ilandelayo:
Ngaphezulu kwesitofu esinye sesisombululo esingenanto
1 isampulu yenaliti isisombululo 1#
1 isampuli yenaliti isisombululo 2#
2.8 Ubalo lweziphumo
2.8.1 Indlela yokulinganisa indawo eyincopho yasetyenziselwa ukubala ukucoceka kweHPLC ngokutsala indawo engenanto.
2.8.2 Ukutenxa kuthetha ukutenxa kococeko lweenaliti ezimbini aziyi kuba nkulu kune-1%
2.8.3 Ukuba iziphumo zazo zombini iinaliti ziyahlangabezana nemilinganiselo yokwamkelwa, ucoceko oluqhelekileyo luthathwa njengesiphumo sokugqibela.
3, Indawo yokunyibilika -- RY-1 isixhobo sendawo yokunyibilika
4. Ilahleko kwindlela yokuvavanya ukomisa
4.1 Izixhobo:
I-oven yokumisa i-thermostatic yombane, ibhalansi ye-1/10,000.
4.2 Inkqubo:
Kwibhotile yokulinganisa i-flat kunye nesisindo esingaguqukiyo kunye nesigqubuthelo somlomo womhlaba owomileyo, linganisa i-gram ye-1 (echanekileyo ukuya kwi-0.0001 gram) yesampuli.Isampulu kufuneka isasazwe ngokulinganayo emazantsi ebhotile yokulinganisa ngobunzima obungekho ngaphezu kwe-10mm, ifakwe kwi-oven yokumisa yombane ye-thermostatic, yome kwi-105 ~ 110 ℃ ngeeyure ze-3, kwaye emva koko ungene kwigumbi lokumisa ukuze uphole. ubushushu begumbi lokulinganisa.
Ukubala: Ilahleko ekomisweni %= (M1-M2) ÷M×100
Kuphi: M1: ubunzima besampulu kunye nebhotile yokulinganisa ngaphambi kokumisa, iigram
I-M2: ubunzima besampuli kunye nebhotile yokulinganisa emva kokumisa, kwiigram
M: Ubunzima besampulu, iigram
5. Ukujikeleza okuthe ngqo
-- Ukujikeleza okuthe ngqo kulinganiswa ngokuhambelana ne-GB/T613-1988
Ukulungiswa kwesampuli: isampuli ye-0.5000g ilinganiswe ngokuchanekileyo kwaye ihanjiswe kwibhotile ye-volumetric ecocekileyo neyomileyo ye-50ml, i-20ml i-DMF yongezwa, ibhotile yayifakwe i-capped kwaye ishukunyiswe ukuchithwa, kwaye ihlanjululwe kwisikali kunye ne-DMF.
Uvavanyo: Lungisa i-zero ye-gyroscope ngaphambi kovavanyo, uze ulayishe ityhubhu yokuvavanya kunye nesisombululo sesampuli, urekhode i-Angle yokujikeleza, kwaye ubale ukujikeleza okuthe ngqo kwesampuli kunye nefomula elandelayo.
[а]D20=(r×50) ÷ (L×W)
[а]D20: Ukujikeleza okuthe ngqo kwi-25 ℃ yesisombululo sesampuli
r: Ukujikeleza okubonakalayo kwi-20 ℃ kwisisombululo sesampuli
50: Umthamo wesisombululo sesampulu esilungisiweyo (ml)
w: Ubunzima besampulu (g)
L: Ubude betyhubhu ejikelezayo yokubona (dm)
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.
UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.
Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
Iimpawu zeHazard Xi - Irritant
Iikhowudi zoMngcipheko 36/37/38 - Ukucaphukisa amehlo, inkqubo yokuphefumula kunye nesikhumba.
Inkcazelo yoKhuseleko S22 - Musa ukuphefumla uthuli.
I-S24/25 - Gwema ukudibana nolusu kunye namehlo.
S36/37/39 - Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo / ubuso.
S27 - Khulula ngoko nangoko zonke iimpahla ezingcolisekileyo.
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
WGK eJamani 3
Ikhowudi yeHS 2922491990
I-N-Fmoc-L-Leucine (i-Fmoc-Leu-OH) (i-CAS: 35661-60-0) i-amino acid derivative enokuthi ilungiswe ngokusabela kwe-L-Leucine kunye ne-9-Fluorenomethoxycarbonyl Chloride.
I-Fmoc-amino acids, esetyenziswa kwi-peptide synthesis, esetyenziswa njenge-organic synthesis ephakathi, i-pharmaceutical intermediate, i-biochemical reagent okanye i-chemical reagent.
I-Fmoc-L-Leu-OH, i-amino acid derivative, esetyenziswa kwi-peptide chemistry.Ibhloko yokwakha esemgangathweni yesiqhelo yesigaba esiqinileyo se-peptide synthesis elandela i-Fmoc-tactics.Kwakhona enye yenoveli ye-PPARγ ligands enokuthi isebenze i-PPARγ ngeendlela ezahlukeneyo, ezinciphisa ukuhlukana kwe-osteoclasts, kwaye ngoko ke iithagethi ezingcono zonyango kwi-diabetes kuneziyobisi zendabuko ze-antidiabetic.
Ukulungiswa kwe-1.05g (0.008 mol) I-L-Leucine eqinileyo inyibilikiswa kwisisombululo se-10% ye-sodium carbonate, ixutywe ukunyibilikisa ngokupheleleyo i-glycine eqinileyo, kunye ne-9-fluorene methoxycarbonyl chloride (2.10g, 0.008 mol) isisombululo esinyibilikisiwe kwi-toluene (2 ~ 205 ml) yongezwa nge-dropwise kwi-20 ~ 30 ℃, ukudibanisa kwe-30 ~ 60 imizuzu, ukuphelisa ukongezwa kwe-dropwise, gxuma kwi-20 ~ 30 ℃ ngeeyure ze-1 ~ 8, yongeza i-30-200 ml yamanzi ukuze udibanise, kwaye ukhuphe nge-n-butyl. I-acetate (80 ml) ukususa i-9-fluorene methoxycarbonyl chloride engaphezulu, Isigaba esifunyenweyo se-aqueous sifakwe kwi-acidified hydrochloric acid kwi-PH = 0.5 ~ 3.5, kwaye emva koko ikhutshwe nge-n-butyl acetate (80 ml), kunye nesigaba seoli esifunyenweyo. ihlanjwe ngamanzi ukuze isuse i-hydrochloric acid, isigaba seoli sasigxininiswe ekususeni i-n-butyl acetate solvent, i-crystals emhlophe yatshitshiswa, yahluzwa kwaye yomiswa ukuze ifumane i-2.46g ye-Nα-9-fluorene methoxycarbonyl-L-leucine, kunye nesivuno se-87.0 %.
-
L-Arginine Hydrochloride CAS 1119-34-2 (H-Arg-O...
-
BOP-Cl CAS 68641-49-6 Peptide Coupling Reagent ...
-
Boc-L-Norvaline DCHA CAS 67861-96-5 Assay >98.0...
-
I-S-Methyl-L-Cysteine CAS 1187-84-4 H-Cys(Me)-OH ...
-
O-Benzyl-L-Serinol Hydrochloride CAS 58577-87-0...
-
BOP Reagent CAS 56602-33-6 Peptide Coupling Rea...