Fondaparinux Sodium CAS 114870-03-0 API
Ukubonelela ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leKhemikhali: Fondaparinux Sodium
CAS: 114870-03-0
I-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor
Umgangatho ophezulu we-API, iMveliso yoRhwebo
Igama leMchiza | Fondaparinux Sodium |
Inombolo yeCAS | 114870-03-0 |
Inombolo yeCAT | RF-API84 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
Ifomula yeemolekyuli | C31H43N3O49S8.10Na |
Ubunzima beMolekyuli | 1728.08 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya kwi-Off-White Powder |
Indlela yoVavanyo / yoHlahlelo | 95.0% ~ 103.0% (kwisiseko somisiwe) |
Ukunyibilika | Inyibilika ngokukhululekileyo emanzini, 2.0M iSodium Chloride kunye ne-0.5M yeSodium Hydroxide kunye ne-Insoluble kwi-Ethanol |
Ukuchongwa kwe-13C-NMR | I-Resonances ye-Fondaparinux Sodium kufuneka igcinwe kwi-58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7, pp.Ukutshintshwa kweeKhemikhali zale miqondiso akwahlukanga ngaphezu kwe-± 0.3ppm yeminye imiqondiso yokuphakama okuguquguqukayo kunye nokutshintsha kweekhemikhali, okubangelwa yi-Fondaparinux Sodium, mhlawumbi ibonwa phakathi kwe-58.0 ~ 80.5 ppm kunye ne-98.7 ~ 104.5ppm. |
Ukuchongwa kwe-HPLC | Ixesha lokugcinwa kwencopho enkulu yesisombululo sesampulu sihambelana nesisombululo esiqhelekileyo |
Ukuchongwa kwe-AAS | I-sodium kufuneka ibe neempawu zokufunxa kwi-330.2nm phantsi kokumiselwa kwe-sodium |
pH | 6.0~8.0 |
Isodium (Na) | 11.5% ~ 15.0% (Ibalwe kwi-anhydrous kunye nezinyibilikisi zasimahla) |
Isulfate yasimahla | ≤0.30% |
I-Chloride eseleyo | ≤1.00% |
Izinto ezinxulumeneyo | |
Ukungcola A | ≤0.80% |
Ukungcola B | ≤0.60% |
Ukungacoceki Okunye | ≤0.30% |
Ukungcola ngokupheleleyo | ≤2.00% |
Izinyibilikisi ezishiyekileyo | |
IMethanol | ≤3000ppm |
I-Ethanol | ≤5000ppm |
I-Ethyl Acetate | ≤5000ppm |
I-DMF | ≤880ppm |
I-methylbenzene | ≤890ppm |
I-Pyridine | ≤50ppm |
Isiqulatho samanzi (KF) | ≤15.0% |
Iintsholongwane ze-Endotoxins | ≤3.3EU/mg |
Umda weMicrobial | Inani elipheleleyo leMicroorganisms ≤100cfu/g |
Umgangatho woVavanyo | uMgangatho woShishino;Umgangatho we-United States Pharmacopoeia (USP). |
Ukusetyenziswa | I-API, i-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
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I-Fondaparinux Sodium (i-CAS 114870-03-0) ngowokuqala kwiklasi entsha ye-antithrombotic anticoagulant yeekhemikhali ezinxulumene ne-low molecular weight heparins (LMWH).I-Fondaparinux sodium yi-factor Xa inhibitor ukwenza indawo ephezulu yokubopha i-anti-coagulant factor antithrombin III (ATIII).I-Fondaparinux yokubopha i-sodium kule ndawo yenza i-natural inhibitory effect ye-ATIII ngokuchasene ne-factor Xa yinto emalunga ne-300, ekhokelela ekuthinteleni ukuveliswa kwe-thrombin.Ithengiswa yiGlaxoSmithKline.Ushicilelo lwegeneric oluphuhliswe yi-Alchemia luyathengiswa ngaphakathi e-US nguGqirha Reddy's Laboratories.I-Fondaparinux sodium yaziswa okokuqala e-US kwi-prophylaxis ye-vein thrombosis enzulu enokuthi ikhokelele kwi-pulmonary embolism emva kotyando olukhulu lwamathambo.Le molekyuli yokwenziwa ngokupheleleyo yikopi yolandelelwano lwe-heparin pentasaccharide, elona qhekeza lifutshane likwaziyo ukwenza i-antithrombin lllmediated inhibition ye-factor Xa ngaloo ndlela inqanda ukuveliswa kwe-thrombin ngaphandle kwesenzo se-antithrombin.
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Fondaparinux Sodium CAS 114870-03-0 API
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