Fondaparinux Sodium CAS 114870-03-0 API

Inkcazelo emfutshane:

Igama leKhemikhali: Fondaparinux Sodium

CAS: 114870-03-0

Imbonakalo: Mhlophe ukuya kwi-Off-White Powder

Uvavanyo: 95.0% ~ 103.0% (kwisiseko esomileyo)

I-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

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Inkcazo:

Ukubonelela ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leKhemikhali: Fondaparinux Sodium
CAS: 114870-03-0
I-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor
Umgangatho ophezulu we-API, iMveliso yoRhwebo

Iipropati zeMichiza:

Igama leMchiza	Fondaparinux Sodium
Inombolo yeCAS	114870-03-0
Inombolo yeCAT	RF-API84
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram
Ifomula yeemolekyuli	C31H43N3O49S8.10Na
Ubunzima beMolekyuli	1728.08
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kwi-Off-White Powder
Indlela yoVavanyo / yoHlahlelo	95.0% ~ 103.0% (kwisiseko somisiwe)
Ukunyibilika	Inyibilika ngokukhululekileyo emanzini, 2.0M iSodium Chloride kunye ne-0.5M yeSodium Hydroxide kunye ne-Insoluble kwi-Ethanol
Ukuchongwa kwe-13C-NMR	I-Resonances ye-Fondaparinux Sodium kufuneka igcinwe kwi-58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7, pp.Ukutshintshwa kweeKhemikhali zale miqondiso akwahlukanga ngaphezu kwe-± 0.3ppm yeminye imiqondiso yokuphakama okuguquguqukayo kunye nokutshintsha kweekhemikhali, okubangelwa yi-Fondaparinux Sodium, mhlawumbi ibonwa phakathi kwe-58.0 ~ 80.5 ppm kunye ne-98.7 ~ 104.5ppm.
Ukuchongwa kwe-HPLC	Ixesha lokugcinwa kwencopho enkulu yesisombululo sesampulu sihambelana nesisombululo esiqhelekileyo
Ukuchongwa kwe-AAS	I-sodium kufuneka ibe neempawu zokufunxa kwi-330.2nm phantsi kokumiselwa kwe-sodium
pH	6.0~8.0
Isodium (Na)	11.5% ~ 15.0% (Ibalwe kwi-anhydrous kunye nezinyibilikisi zasimahla)
Isulfate yasimahla	≤0.30%
I-Chloride eseleyo	≤1.00%
Izinto ezinxulumeneyo
Ukungcola A	≤0.80%
Ukungcola B	≤0.60%
Ukungacoceki Okunye	≤0.30%
Ukungcola ngokupheleleyo	≤2.00%
Izinyibilikisi ezishiyekileyo
IMethanol	≤3000ppm
I-Ethanol	≤5000ppm
I-Ethyl Acetate	≤5000ppm
I-DMF	≤880ppm
I-methylbenzene	≤890ppm
I-Pyridine	≤50ppm
Isiqulatho samanzi (KF)	≤15.0%
Iintsholongwane ze-Endotoxins	≤3.3EU/mg
Umda weMicrobial	Inani elipheleleyo leMicroorganisms ≤100cfu/g
Umgangatho woVavanyo	uMgangatho woShishino;Umgangatho we-United States Pharmacopoeia (USP).
Ukusetyenziswa	I-API, i-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

Izinto eziluncedo:

FAQ:

Isicelo:

I-Fondaparinux Sodium (i-CAS 114870-03-0) ngowokuqala kwiklasi entsha ye-antithrombotic anticoagulant yeekhemikhali ezinxulumene ne-low molecular weight heparins (LMWH).I-Fondaparinux sodium yi-factor Xa inhibitor ukwenza indawo ephezulu yokubopha i-anti-coagulant factor antithrombin III (ATIII).I-Fondaparinux yokubopha i-sodium kule ndawo yenza i-natural inhibitory effect ye-ATIII ngokuchasene ne-factor Xa yinto emalunga ne-300, ekhokelela ekuthinteleni ukuveliswa kwe-thrombin.Ithengiswa yiGlaxoSmithKline.Ushicilelo lwegeneric oluphuhliswe yi-Alchemia luyathengiswa ngaphakathi e-US nguGqirha Reddy's Laboratories.I-Fondaparinux sodium yaziswa okokuqala e-US kwi-prophylaxis ye-vein thrombosis enzulu enokuthi ikhokelele kwi-pulmonary embolism emva kotyando olukhulu lwamathambo.Le molekyuli yokwenziwa ngokupheleleyo yikopi yolandelelwano lwe-heparin pentasaccharide, elona qhekeza lifutshane likwaziyo ukwenza i-antithrombin lllmediated inhibition ye-factor Xa ngaloo ndlela inqanda ukuveliswa kwe-thrombin ngaphandle kwesenzo se-antithrombin.