Fulvestrant (ICI 182780) CAS 129453-61-8 API Factory High Quality

Inkcazelo emfutshane:

Igama: Fulvestrant (ICI 182780)

CAS: 129453-61-8

Imbonakalo: Mhlophe ukuya kuMhlophe-Mhlophe wePowder

Uvavanyo: 97.0% ~ 102.0% (kwisiseko somisiwe)

I-Fulvestrant isetyenziswa kunyango lwe-hormone-sensitive advanced umhlaza webele kubasetyhini abasemva kokuya exesheni.

Umgangatho ophezulu we-API, iMveliso yoRhwebo

Inquiry: alvin@ruifuchem.com

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Inkcazo:

Ubonelelo lwabavelisi ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama: Fulvestrant
CAS: 129453-61-8
I-Fulvestrant isetyenziswa kunyango lwe-hormone-sensitive advanced umhlaza webele kubasetyhini abasemva kokuya exesheni.
Umgangatho ophezulu we-API, iMveliso yoRhwebo

Iipropati zeMichiza:

Igama leMchiza	I-Fulvestrant
Izithethantonye	(7α,17β) -7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol;ICI 182780
Inombolo yeCAS	129453-61-8
Inombolo yeCAT	RF-API81
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram
Ifomula yeemolekyuli	I-C32H47F5O3S
Ubunzima beMolekyuli	606.77
Indawo yokunyibilika	104.0 ~ 106.0℃
Ukunyibilika	Inyibilika kwiMethanol, iEthanol;Ayinyibilikiyo emanzini
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kuMhlophe oMhlophe wePowder
Ukuchongwa	Ngo-IR, HPLC
Ujikelezo oluKhethekileyo lwe-Optical	+108.0 ° ukuya +115.0 °
Ilahleko ekomisweni	≤0.50%
Intsalela kwi-Ignition	≤0.10%
I-6-Keto-Fulvestrant	≤0.10%
6,7-Fulvestrant	≤0.10%
I-Fulvestrant Sulfone	≤0.20%
I-Fulvestrant Yandisiwe	≤0.30%
I-Fulvestrant sterol Dimmer	≤0.80%
Nakuphi na Umntu Ngamnye Ukungcola Okungachazwanga	≤0.10%
Ukungcola ngokupheleleyo	≤1.0%
UFulvestrant A	42.0%~48.0%
UFulvestrant B	52.0%~58.0%
I-DMF	≤620ppm
Iintsimbi ezinzima	≤10ppm
Isivavanyi	97.0% ~ 102.0% (kwisiseko somisiwe)
Ugcino	Londoloza kwizikhongozeli ezivalwe kakuhle ezikwaziyo ukumelana nokukhanya kwivenkile efrijini kwi-2~8℃
Umgangatho woVavanyo	Umgangatho we-United States Pharmacopoeia (USP).
Ukusetyenziswa	I-Estrogen Receptor Antagonist

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

Izinto eziluncedo:

FAQ:

Isicelo:

I-Fulvestrant (ICI-182780) I-CAS 129453-61-8, iyiyobisi ye-injection ye-muscle eyenziwe yinkampani i-AstraZeneca kwaye isetyenziselwa unyango lwe-hormone-sensitive ephezulu yomhlaza webele kubasetyhini be-postmenopausal.I-Fulvestrant kuphela kwechiza le-antiestrogen elinokusetyenziswa ngokubanzi ekliniki emva kokungaphumeleli unyango lwe-tamoxifen.Eli chiza luhlobo lonyango lwe-endocrine, ngoko ke aliyi kubangela nayiphi na imiphumo emibi ebonwa rhoqo kwi-chemotherapy, inika ukuthotyelwa kwesigulane.Izilingo ezininzi zeklinikhi zifumene ukuba i-250mg Fulvestrant iyasebenza kwaye ihlala ikhuselekile njengomgca wesibini wonyango lomhlaza webele ophezulu.I-Fulvestrant yi-synthetic Estrogen Receptor (ER) Umchasi kunye ne-IC50 ye-0.94 nM kwi-assay-free assay.I-Fulvestrant iphinda ibangele i-autophagy kunye ne-apoptosis kwaye inomsebenzi we-antitumor.