Ganciclovir CAS 82410-32-0 API BW 759 GCV Antiviral CMV Inhibitor High Quality
Ubonelelo lwabavelisi ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leMichiza: Ganciclovir
CAS: 82410-32-0
I-Agent ye-Antiviral yoNyango lwe-Cytomegalovirus (CMV) Infection
Umgangatho ophezulu we-API, iMveliso yoRhwebo
Igama leMchiza | Ganciclovir |
Izithethantonye | GCV;BW 759;9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine;I-2-Amino-9- (1,3-dihydroxypropan-2-yloxymethyl) -3H-purin-6-enye;2'-Nor-2'-Deoxyguanosine |
Inombolo yeCAS | 82410-32-0 |
Inombolo yeCAT | RF-API82 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C9H13N5O4 |
Ubunzima beMolekyuli | 255.23 |
Indawo yokunyibilika | 250℃ |
Ubushushu boGcino | 2-8℃ |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder |
Ukunyibilika | Kancinci kakhulu ukuNyibilika emanzini |
Ukuchongwa | Ukufunxwa kwe-Ultraviolet, i-Infrared Absorption |
Ilahleko ekomisweni | ≤6.0% |
Intsalela kwi-Ignition | ≤0.10% |
Izinto ezinxulumeneyo | I-Ganciclovir Related Compound A ≤0.50% |
Umda weGuanine | ≤0.50% |
Intsalela yezinyibilikisi (GC) | I-Ethanol ≤5000ppm |
Iintsimbi ezinzima | ≤10ppm |
I-Coefficient yokufunxa | 516-548 kwi-252nm |
Iintsholongwane ze-Endotoxins | ≤0.84EU/mg |
Isivavanyi | 98.0%~102.0% (Titration) |
Umgangatho woVavanyo | uMgangatho woShishino;Umgangatho we-United States Pharmacopoeia (USP). |
Ukusetyenziswa | API, CMV Inhibitor |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
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I-Ganciclovir (i-CAS 82410-32-0) iyeye-nucleoside antiviral drug, luhlobo lwe-guanosine derivatives.I-Ganciclovir yi-agent ye-antiviral esebenzayo eboniswe kwi-parenterally-active antiviral eboniswe kumbono- okanye ubomi obusongela usulelo lwe-cytomegalovirus (CMV) kwizigulana ezibuthathaka.Ine-spectrum ebanzi, i-high-efficient inhibitory effects kwi-herpes virus kwaye iyeza lokuqala lokukhetha unyango lwe-cytomegalovirus usulelo olunempembelelo enamandla kwintsholongwane ye-hepatitis B kunye ne-adenovirus ngokunjalo.Yi-homologue ye-acyclovir (ACV) kunye nefuthe layo le-antiviral efana ne, kodwa yomelele kune-aciclovir, eneziphumo ezinamandla ngakumbi zokuthintela kwi-cytomegalovirus ehambelana nezigulana zikaGawulayo.Yiklinikhi esetyenziselwa unyango lwesigaba sokungeniswa kunye nesigaba sokulondoloza kwizigulane ezingenasifo (kubandakanywa nezigulane ze-AIDS) kunye ne-cytomegalovirus retinitis.Ingasetyenziselwa ukuthintela isifo se-cytomegalovirus kwizigulane ezifumana ukutshintshwa kwamalungu okanye izigulane ze-AIDS ezineziphumo ezilungileyo kwi-cytomegalovirus serology test.
I-Ganciclovir (i-CAS 82410-32-0) yinto esebenza kakhulu, i-low-toxicity kunye ne-high-selectivity inhibitor ye-virus eyenziwe yiNkampani ye-Syntex (eUnited States).Lichiza lokuqala elivunyiweyo yi-US FDA kunyango lwe-cytomegalovirus (CMV) usulelo.I-Syntex inikwe ilungelo elilodwa lokuvelisa.NgoJuni ka-1988, le tablet yamkelwa okokuqala ngqa ukuba idweliswe e-UK, kulandelwa kukwamkelwa ngokulandelelanayo yiFransi, iUnited States, iJapan, kunye neWest Germany, i-Italiya neKhanada namanye amazwe.Kuze kube sekupheleni kukaJuni 1999, kuye kwavunywa kumazwe angaphezu kwama-70 kunye nemimandla yokuthintela izigulane ze-immunodeficiency kunye nosulelo lwe-cytomegalovirus lwezigulane ze-organ transplantation.Ngo-2002, iipilisi ze-Ganciclovir zifumene imvume ye-FDA, zifumaneka ngoku.
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