H-Gly-OMe·HCl CAS 5680-79-5 Glycine Methyl Ester Hydrochloride Assay >99.0%

1. Iipropati: Le mveliso kufuneka ibe ngumgubo omhlophe wekristale.
2. Isivavanyi:
1) Ukuzimisela kweGlycine Methyl Ester Hydrochloride assay
1.1 Indlela
Ngaphantsi kweemeko ze-acidic, isampuli iphendula ngexabiso elithile le-nitrate yesilivere, kwaye i-nitrate yesilivere engaphezulu ibuyiselwa nge-ammonium thiocyanate, ibhekisela kwi-ammonium ferric sulfate.
Njengesalathisi, umxholo we-chlorine opheleleyo unqunywe ngokomthamo wesisombululo esiqhelekileyo esisetyenzisiweyo, kwaye umxholo we-chlorine opheleleyo ukhutshwe kumxholo we-glycine hydrochloride ukufumana umxholo we-Glycine Methyl Ester Hydrochloride.
1.2 IiReagents
iDibutyl phthalate;
Isisombululo se-nitric acid: 2 + 3;
Isisombululo esisemgangathweni se-nitrate yeSilver: c(AgNO3) = 0.1 mol/L
Isisombululo setitration esisezantsi se-Ammonium thiocyanate: c(NH4SCN) = 0.1 mol/L
I-Ammonium ferric sulfate (III) isalathisi solwelo: 80 g/L
1.3 Inkqubo yoHlalutyo
Ubunzima malunga ne-0.5g yesampuli, echanekileyo ukuya kwi-0.0001g.Beka kwi-250ml ye-conical flask, inyibilikise ku-40ml yamanzi, yongeza i-10 ml yesisombululo se-nitric acid, Yongeza (50 ± 0.02) mL yesilivere yesilivere ye-nitrate isisombululo se-titration, 3mL isisombululo sesalathisi se-ammonium ferric sulfate, 4mL dibutyl phthalate, kunye nesisombululo se-thiocyanate ye-thiocyanate ye-thiocyanate i-titrated de isisombululo sibe mdaka okhanyayo kwaye sahlala singenambala kwi-30 s.
1.4 Ubalo lweziphumo
Iqhezu elinzima lomxholo we-glycine methyl ester hydrochloric acid w1, echazwa njenge-%, ibalwa ngokweEquation (1):
w1= (c1V1-c2V2)*M/1000/m * 100-w2 *1.126 ifomula (1)
Apho:
I-V1: Umthamo wesisombululo esisezantsi se-nitrate yesilivere ye-nitrate (ml)
I-V2: Umthamo wesisombululo setitration se-ammonium thiocyanate esisetyenziswe yi-titration (ml)
c1: Ixabiso elithe ngqo lesilivere yenitrate isisombululo somgangatho wetitration (mol/L)
c2: Ixabiso elichanekileyo lesisombululo setitration esisemgangathweni se-ammonium thiocyanate (mol/L)
w2: Iqhezu lobuninzi (%) lomxholo we-glycine hydrochloride njengoko kumiselwe kwiCandelo 4.2
M: Ubunzima beMolar ye-glycine methyl ester hydrochloride (g/mol)
I-1.126: Ukuguqulwa kwe-coefficient ye-glycine hydrochloride kwi-Glycine methyl ester hydrochloride.
Ixabiso le-arithmetic lentsingiselo yeziphumo ezimbini zomlinganiselo ofanayo zathathwa njengesiphumo somlinganiselo, kwaye umahluko opheleleyo phakathi kweziphumo ezimbini zomlinganiselo ofanayo wawungekho ngaphezu kwe-0.05%.
2) Ukumiselwa komxholo we-glycine hydrochloride
2.1 Indlela
Ukusebenzisa i-dimethyl yellow njengesalathisi, isampuli yaxutywa kunye nesisombululo se-sodium hydroxide standard titrating, kwaye umthamo wesisombululo wawuxutywe ngokusetyenziswa kwe-sodium hydroxide standard.
Bala umxholo we-glycine hydrochloride.
2.2 I-Reagent
Isisombululo esisemgangathweni se-titration ye-sodium hydroxide: c (NaOH) = 0.1mol / L
I-Dimethyl etyheli ebonisa ulwelo: 10 g/L
2.3 Inkqubo yoHlalutyo
Ubunzima malunga ne-5.0 g yesampulu yaselabhoratri, ichanekile ukuya kwi-0.0001g, kwibhekile eyi-200 ml, nyibilike ngamanzi angama-50ml, kwaye wongeze amathontsi ama-5 edimethyl.
Ulwelo olubonisa ulwelo, kunye nesodium hydroxide esemgangathweni yetitration isisombululo de isisombululo ukusuka ebomvu ukuya kumthubi orenji sisiphelo
2.4 Ukubalwa kweziphumo
Iqhezu lobunzima be-w2 lomxholo we-glycine hydrochloride lichazwa njenge-% kwaye libalwe ngokwe-Equation (2):
w2 =(V/1000)cM/m *100 ifomula (2)
Apho:
V: Umthamo wesodium hydroxide isisombululo esisezantsi setitration (mL)
c: Ixabiso elichanekileyo lesodium hydroxide standard titration solution (mol/L)
M: Ubunzima beMolari ye-glycine hydrochloride (g/mol)
m: Ixabiso lobunzima besampulu (g)
Ixabiso le-arithmetic elithetha nge-arithmetic yeziphumo zomlinganiselo onxuseneyo wathathwa njengesiphumo somlinganiselo, kwaye umahluko opheleleyo phakathi kweziphumo zomlinganiselo onxuseneyo wawungekho ngaphezu kwe-0.05%
3. Indawo yokunyibilika: Ngokwendlela yokumisela indawo yokunyibilika (i-Chinese Pharmacopoeia 2010 Appendix VIC), uluhlu lwendawo yokunyibilika luyi-172-178 ºC.
4. Ukomisa ubunzima bobunzima: thatha le mveliso kwi-105.0 ℃ kwaye uyomise ukuba ube nobunzima obuqhubekayo.Ukulahlekelwa kwesisindo akuyi kudlula i-0.5%.
5. Ukugcinwa: Le mveliso kufuneka ifakwe efrijini kude nokukhanya.