Histamine Dihydrochloride CAS 56-92-8 Assay 98.5~101.0% (Titration) Factory
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we-Histamine Dihydrochloride (CAS: 56-92-8) kunye nomgangatho ophezulu.Impahla engekasilwaL-Histidine (H-His-OH) (CAS: 71-00-1)Sinokubonelela ngeenkonzo zehlabathi, ezincinci kunye nezixa ezininzi ezikhoyo.Ukuba unomdla kwi-Histamine Dihydrochloride,Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-Histamine Dihydrochloride |
| Izithethantonye | I-Histamine 2HCl;I-Histamine DiHCl;2-(4-Imidazolyl) ethylamine Dihydrochloride;I-2-(1H-Imidazol-4-yl) ethylamine Dihydrochloride;I-2-(1H-Imidazol-4-yl) ethylamine Dihydrochloride;1H-Imidazole-4-ethanamine Dihydrochloride;Celene;Peremin |
| Ubume beStokhwe | KwiSitokhwe, Umthamo weMveliso iiToni ezingama-20 ngenyanga |
| Inombolo yeCAS | 56-92-8 |
| Ifomula yeemolekyuli | C5H9N3·2HCl |
| Ubunzima beMolekyuli | 184.06 |
| Indawo yokunyibilika | 247.0~249.0℃(lit.) |
| Ukuxinana | 1.14 |
| Inovakalelo | Hygroscopic |
| Ukunyibilika kwamanzi | Inyibilika ngokugqibeleleyo emanzini, iphantse yacaca |
| Ukunyibilika | I-Soluble kakhulu kwi-Methanol, i-Soluble kwi-Ethanol, i-Soluble kwi-Ether |
| Ugcino Temp. | Itywinwe kwindawo eyomileyo, iVenkile kwindawo yobushushu beGumbi |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Uphawu | Ruifu Chemical |
| Iikhowudi zeNgozi | Xn,Xi | RTECS | MS1575000 |
| Iingxelo zoMngcipheko | 36/37/38-42/43-42-22 | F | 1-8-9 |
| Iingxelo zoKhuseleko | 22-26-36/37/39-45-37-36/37 | I-TSCA | Ewe |
| I-RIDADR | 3335 | IKlasi yeeNgozi | Iyacaphukisa |
| WGK eJamani | 2 | Ikhowudi ye-HS | 2933990099 |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Iikristale eziMhlophe okanye umgubo weCrystalline | Iyahambelana |
| Ukuchongwa | I-Infrared Absorption Spectrum | Iyahambelana |
| Imbonakalo yesisombululo | Cacileyo | Dlula |
| I-Histidine (TLC) | Ayifunyaniswa | Iyahambelana |
| Isulfate (SO4) | ≤0.020% | <0.020% |
| Intsimbi (Fe) | ≤10ppm | <10ppm |
| Iintsimbi ezinzima (Pb) | ≤10ppm | <10ppm |
| IArsenic (As2O3) | ≤10ppm | <10ppm |
| Ilahleko ekomisweni | ≤0.50% | 0.24% |
| Uthuthu lweSulfated | ≤0.20% | 0.06% |
| Isivavanyi | 98.5 ukuya kwi-101.0% (nge-Titration) | 99.36% |
| Ixabiso le-pH | 2.85 ukuya ku-3.60 (10% aq. Isisombululo) | 3.16 |
| Ukuqukumbela | Ngokuvumelana noMgangatho we-AJI97, EP9.0 | |
| Usetyenziso oluphambili | IiAmino Acids;Izongezo zokutya;AbaPhakathi bamayeza | |
IMathiriyeli ekrwada kunye neZinyibilikisi eziBandakanywe kwiNkqubo ye-Synthesis
Iimpahla ezingekasilwa:
L-Histidine (H-His-OH) CAS 71-00-1
I-Acetophenone CAS 98-86-2
I-Hydrochloric Acid CAS 7647-01-0
Izinyibilikisi
I-Diethylene Glycol CAS 111-46-6
I-Ethanol CAS 64-17-5
Isopropyl Utywala CAS 67-63-0
Amanzi
I-Histamine Dihydrochloride (CAS: 56-92-8) EP9.0 UmthamoⅡ Indlela yoVavanyo
INGCACISO
I-Histamine dihydrochloride ayinayo ngaphantsi kweepesenti ze-98.5 kwaye ingabi ngaphezu kwe-101.0 yeepesenti ze-2-(1H-imidazol-4-yl) ethan-1-amine dihydrochloride, ibalwa ngokubhekiselele kwinto eyomileyo.
ABAlinganiswa
Imhlophe okanye iphantse imhlophe, icrystalline powder okanye iicrystals ezingenambala, ihygroscopic, zinyibilika kakhulu emanzini, zinyibilika etywaleni.
UKUCHAZA
Isazisi sokuqala: A, D.
Isazisi sesibini: B, C, D
A. Hlola nge-infrared absorption spectrophotometry (2.2.24), ngokuthelekisa ne-spectrum efunyenwe nge-histamine dihydrochloride CRS.Hlola njengeediski ezilungiselelwe usebenzisa i-1 mg yezinto.
B. Hlola iichromatograms ezifunyenwe kuvavanyo lwe-histidine.Indawo ephambili kwichromatogram efunyenwe ngesisombululo sovavanyo (b) iyafana kwindawo, umbala kunye nobukhulu kwindawo ephambili kwikhromatogram efunyenwe ngesisombululo sereferensi (a).
C. Dissolve 0.1 g kwi-7 mL yamanzi R kwaye wongeze i-3 mL ye-200 g / L isisombululo se-sodium hydroxide R. Dissolve i-50mg ye-sulfanilic acid R kumxube we-0.1 mL ye-hydrochloric acid R kunye ne-10 mL yamanzi R kunye yongeza i-0.1 mL yesisombululo se-sodium nitrite R. Yongeza isisombululo sesibini sokuqala kwaye udibanise.Umbala obomvu uveliswa.
D. Inika ukusabela (a) kweekloridi (2.3.1).
UVAVANYO
Isisombululo S. Dissolve 0.5g kumanzi e-carbon dioxide-free R elungiselelwe ukusuka kumanzi adibeneyo R kwaye udibanise kwi-10 mL kunye ne-solvent efanayo.
Ukubonakala kwesisombululo.Isisombululo S sicacile (2.2.1) kwaye singabi nombala ogqithiseleyo kunesisombululo sereferensi Y7 (2.2.2, Indlela II).
pH (2.2.3).I-pH yesisombululo S yi-2.85 ukuya kwi-3.60.
I-Histidine.Jonga ngekhromatografi ecekethekileyo (2.2.27), usebenzisa i-silica gel ye-TLC ye-G plate R.
Isisombululo sovavanyo (a).Dissolve i-0.5g yezinto eziza kuhlolwa emanzini R kwaye udibanise kwi-10 mL kunye ne-solvent efanayo.
Isisombululo sovavanyo (b).Nciphisa i-2 mL yesisombululo sovavanyo (a) ukuya kwi-10 mL ngamanzi R.
Isisombululo seReferensi (a).Dissolve 0.1 g ye-histamine dihydrochloride CRS emanzini R kwaye udibanise kwi-10 mL kunye ne-solvent efanayo.
Isisombululo seReferensi (b).Dissolve i-50 mg ye-histidine monohydrochloride R emanzini R kwaye udibanise kwi-100 mL kunye ne-solvent efanayo.
Isisombululo seReferensi (c).Xuba i-1 mL yesisombululo sovavanyo (a) kunye ne-1 mL yesisombululo sereferensi (b).
Faka kwipleyiti ye-1 μL yesisombululo sovavanyo (a), i-1 μL yesisombululo sovavanyo (b), i-1 μL yesisombululo sereferensi (a), i-1 μL yesisombululo sereferensi (b) kunye ne-2 μL yesisombululo sereferensi (c).Phuhlisa phezu kwendlela ye-15cm usebenzisa umxube we-5volumes ye-ammonia R egxininisiweyo, imiqulu engama-20 yamanzi R kunye ne-75 imiqulu ye-acetonitrile R. Yomisa ipleyiti emoyeni wangoku.Phinda uphuhliso kwicala elifanayo, yomisa ipleyiti kwi-curren yomoya kwaye utshize ngesisombululo se-ninhydrin R1.Ukushisa iplate kwi-110 ° C kwi-10 min.Nayiphi na indawo ehambelana ne-histidine kwichromatogram efunyenwe ngesisombululo sovavanyo (a) ayinamandla ngaphezu kwendawo ekwichromatogram efunyenwe ngesisombululo sereferensi (b) (1 pesenti).Uvavanyo alusebenzi ngaphandle kokuba ichromatogram efunyenwe kunye nesisombululo sereferensi (c) ibonisa amabala ama-2 ahluke ngokucacileyo.
IiSulfates (2.4.13).I-3mL yesisombululo S ehlanjululwe kwi-15 mL ngamanzi adibeneyo R ihambelana novavanyo olulinganiselwe lwe-sulfates (0.1 ekhulwini).
Ilahleko ekomisweni (2.2.32).Akukho ngaphezu kwe-0.5 yepesenti, enqunywe kwi-0.20 g ngokomisa kwi-oven kwi-105 °C.
Uthuthu olufakwe emanzini (2.4.14).Akukho ngaphezu kweepesenti ze-0.1, ezinqunywe kwi-0.5 g.
UVAVANYO
Dissolve 0.080 g kumxube we-5.0 mL we-0.01 M hydrochloric acid kunye ne-50 mL yotywala R. Yenza i-titration ye-potentiometric (2.2.20), usebenzisa i-0.1 M i-sodium hydroxide.Funda ivolumu eyongeziweyo phakathi kwamanqaku okuqala kunye nesithathu e-inflexion.
I-1mL ye-0.1 M i-sodium hydroxideis ilingana ne-9.203 mg ye-C5H11Cl2N3.
UKUGCINA
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Ukusetyenziswa kwe-Histamine Dihydrochloride (CAS: 56-92-8)
1. I-Histamine Dihydrochloride iboniswe ukuba isebenze i-nitric oxide synthetase kwaye icinezele okanye inqanda ukuveliswa kweentlobo ze-oxygen esebenzayo (ROS).Ukuvinjelwa kwe-ROS nge-Histamine Dihydrochloride ivumela ukusebenza kweeseli ze-T kunye neeseli ze-NK nge-IL-2.Kwimodeli yegundane, i-histamine dihydrochloride icinezele i-ROS eyenziwe ngamaseli e-Kupffer ngokusebenzisa i-H2 histamine receptor.I-vasodilator enamandla kunye ne-endogenous histamine receptor agonist.
2. I-Histamine Dihydrochloride (igama lokurhweba i-Ceplene) yityuwa ye-Histamine esetyenziswa njengechiza lokuthintela ukuphindaphinda kwizigulane ezifunyanwe nge-acute myeloid leukemia (AML).
Sisithako esisebenzayo esivunyiweyo se-FDA sokusetyenziswa kwe-analgesic ye-topical kwaye iyafumaneka kwiimveliso ezinje nge-Australian Dream Cream, esetyenziselwa ukuthomalalisa okwethutyana iintlungu ezincinci kunye neentlungu zemisipha kunye namalungu ahambelana nesifo samathambo, umqolo olula, ukugruzuka, ukukruneka, kunye ubunzima.
3. I-Histamine Dihydrochloride isetyenziselwa ukuxolelwa okuqhubekayo kunye nokuthintela ukuphindaphinda kwizigulane zabantu abadala abane-acute myeloid leukemia (AML) emva konyango lokuqala lokuxolelwa.Ichiza linciphisa ukuveliswa kwamaqela e-oksijini nge-autophagocytes, inqanda i-nicotinamide adenine dichemicalbo phosphate oxidase kwaye ithintela i-interleukin-2 ekusebenziseni iiseli ze-NK kunye neeseli ze-T.I-Histamine Dihydrochloride injection yavunywa ngesiseko sokuba ukuxolelwa kwayo ngokupheleleyo kunye ne-interleukin-2 kunciphise kakhulu ukubuyiswa kwakhona kwizigulane ze-AML.
