N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity
Ubonelelo ngezoRhwebo i-Imatinib Mesylate kunye nabaPhakathi abaNxulumeneyo:
I-Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Igama leMchiza | N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea |
| Izithethantonye | I-Imatinib Mesylate ePhakathi;2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine |
| Inombolo yeCAS | 152460-10-1 |
| Inombolo yeCAT | RF-PI230 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C16H15N5 |
| Ubunzima beMolekyuli | 277.32 |
| Indawo yokunyibilika | 133.0-135.0℃ |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | UkuKhanya okuOrenji ukuya kwiPowder emthubi ukuya kwiCrystal |
| Ubunyulu / Indlela yokuHlalutya | ≥98.0% |
| Ilahleko ekomisweni | ≤0.50% |
| Intsalela ekutshisweni | ≤0.50% |
| Ukungcola ngokupheleleyo | ≤2.0% |
| Ukungacoceki okuphezulu okukodwa | ≤1.0% |
| Iintsimbi ezinzima | ≤20ppm |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Phakathi kwe-Imatinib Mesylate (CAS: 220127-57-1) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi okhokelayo kunye nomthengisi we-N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) enomgangatho ophezulu .
I-N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) yindawo ephakathi ngokuqhelekileyo kwi-synthesis ye-Imatinib Mesylate (CAS: 220127-57-1) ) API.
I-Imatinib mesylate yi-molecule encinci evimbela i-c-Abl protein-tyrosine kinase, i-kinase ibaluleke ngokukhethekileyo ekwandeni kwe-myelogenous leukemia engapheliyo (CML).Isiganeko sokudluliselwa phakathi kwe-chromosomes 9 kunye ne-22 ivelisa i-chromosome yasePhiladelphia, ethi emva koko ivelise iprotheni ye-Bcr-Abl ye-fusion kunye nomsebenzi we-aberrant kinase okhuthaza ukwanda kweeseli ngokukhawuleza.I-Imatinib mesylate ibophelela le kinase ibalulekileyo, imisa ukukhula okunxulumene ne-CML.I-Imatinib mesylate iye yaphinda yaboniswa ukuvimbela i-PDGFR kunye ne-tyrosine kinases ehambelana ne-c-Kit.Iifomyula eziqulethe i-Imatinib mesylate zisetyenzisiwe kunyango lwee-cancer ezahlukeneyo.
I-Imatinib mesylate yi-tyrosine kinase inhibitor.Ngokucacileyo kakhulu kwi-BCR-ABL, i-enzyme ehambelana ne-myelogenous leukemia engapheliyo (CML) kunye neendlela ezithile ze-acute lymphoblastic leukemia (ALL).Inamandla kwaye ikhetha i-v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).Kwakhona inqanda i-PDGFR kunye ne-c-kit.Ibonisa ukukhetha kwe-v-Abl phezu kwephaneli yezinye i-tyrosine kunye ne-serine/threonine protein kinases.Ngokukodwa inqanda i-PDGF-evuselelwe ukukhula kweeseli ze-PB-3 eziguqulwayo ze-v-abl kunye ne-v-sis-transformed BALB / c 3T3 iiseli ze-vitro.Ibonisa iziphumo ze-antitumor kwiigundane ezithwala i-AMuLV okanye i-BABL / c 3T3 v-sis iiseli.Ivimbela ukuphindaphinda kwe-SARS-CoV kunye ne-MERS-CoV kwi-vitro (amaxabiso e-EC50 yi-9.823 kunye ne-17.689 μM, ngokulandelanayo).
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)