I-Imatinib Mesylate CAS 220127-57-1 Assay 98.0% ~ 102.0% Ph+CML API Factory High Quality
Ubonelelo ngezoRhwebo i-Imatinib Mesylate kunye nabaPhakathi abaNxulumeneyo:
I-Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Igama leMchiza | I-Imatinib Mesylate (ifomu yealpha) |
| Izithethantonye | I-Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| Inombolo yeCAS | 220127-57-1 |
| Inombolo yeCAT | RF-API19 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | I-C30H35N7O4S |
| Ubunzima beMolekyuli | 589.71 |
| Imeko yokuthumela ngenqanawa | Phantsi koBubushushu be-Ambient |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder |
| Ukunyibilika | Kulula ukunyibilika emanzini |
| Ukuchongwa kwe-HPLC | Ixesha logcino lwesampulu engundoqo liyahambelana noko |
| Ukuchongwa kwe-IR | I-spectrum yokufunxa ye-infrared yesampulu ihambelana nesampulu yereferensi |
| Indawo yokunyibilika | 214.0 ~ 222.0℃ |
| Ilahleko ekomisweni | ≤0.50% |
| Intsalela kwi-Ignition | ≤0.10% |
| Iintsimbi ezinzima | ≤20ppm |
| Izinto ezinxulumeneyo | (1) Ukungcola G: NMT 0.3% |
| (2) Ukungcola B: NMT 0.3% | |
| (3) Ukungcola C: NMT 0.3% | |
| (4) Ukungcola D: NMT 0.3% | |
| (5) Ukungcola A: NMT 0.3% | |
| (6) Ukungcola H: NMT 0.3% | |
| (7) Ukungcola F: NMT 0.3% | |
| (8) Ukungcola E: NMT 0.3% | |
| (9) Obona kungcola kukodwa: NMT0.1% | |
| Izinyibilikisi ezishiyekileyo | (1) I-Ethyl Acetate: NMT 5000ppm |
| (2) IMethanol: NMT3000ppm | |
| (3) IDichloromethane: NMT 600ppm | |
| (4) I-Ethanol: NMT 5000ppm | |
| (5) iToluene: NMT 890ppm | |
| (6) I-Dimethyl Sulfoxide: NMT5000ppm | |
| Uvavanyo lwe-HPLC | 98.0% ~ 102.0% (C30H35N7SO4 Kubalwa kwi-Anhydrous Basis) |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | API;Ph+CML |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Imatinib Mesylate (i-CAS 220127-57-1) i-molecule encinci inqanda i-c-Abl protein-tyrosine kinase, i-kinase ibaluleke ngokukodwa ekukhuliseni i-myelogenous leukemia engapheliyo (CML).Ngokucacileyo kakhulu kwi-BCR-ABL, i-enzyme ehambelana ne-myelogenous leukemia engapheliyo (CML) kunye neendlela ezithile ze-acute lymphoblastic leukemia (ALL).Inamandla kwaye ikhetha i-v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).Isiganeko sokudluliselwa phakathi kwe-chromosomes 9 kunye ne-22 ivelisa i-chromosome yasePhiladelphia, ethi emva koko ivelise iprotheni ye-Bcr-Abl ye-fusion kunye nomsebenzi we-aberrant kinase okhuthaza ukwanda kweeseli ngokukhawuleza.I-Imatinib mesylate ibophelela le kinase ibalulekileyo, imisa ukukhula okunxulumene ne-CML.I-Imatinib mesylate iye yaphinda yaboniswa ukuvimbela i-PDGFR kunye ne-tyrosine kinases ehambelana ne-c-Kit.
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)