Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Factory High Purity
Ubonelelo lwabavelisi be-Irinotecan kunye nabaPhakathi abaNxulumeneyo:
Irinotecan Hydrochloride CAS: 100286-90-6
I-Irinotecan Isiseko sasimahla seCAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
I-7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
I-1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Igama leMchiza | Irinotecan Hydrochloride Trihydrate |
| Izithethantonye | I-Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Inombolo yeCAS | 136572-09-3 |
| Inombolo yeCAT | RF-API52 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C33H38N4O6·HCl·3H2O |
| Ubunzima beMolekyuli | 677.20 |
| Indawo yokunyibilika | 250.0~256.0℃ (dec.) |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo oMthubi oKhanyayo okanye oMthubi |
| Isivavanyi (w/w) | 98.0%~102.0% |
| Ubunyulu (HPLC) | ≥99.5% |
| Ukunyibilika | Inyibilika kancinci emanzini, i-ethanol okanye i-chloroform, Ayinyibiliki kwi-acetone |
| Ukuchongwa | ngu-IR kunye ne-HPLC, Iyahambelana |
| Ujikelezo oluKhethekileyo lwe-Optical | +60°~+73° |
| Amanzi | 7.0%~9.0% |
| Intsalela yezinyibilikisi | Iyahambelana neeMfuno zeICH |
| Intsalela kwi-Ignition | ≤0.20% |
| I-Chloride | 5.0%~6.0% |
| Ixabiso le-pH | 3.0~5.0 |
| Iintsimbi ezinzima | ≤20ppm |
| Ukungcola komntu ngamnye | ≤0.10% |
| Ukungcola ngokupheleleyo | ≤0.50% |
| Imeko yoGcino | Gcina kwi-2-8 ° C, Kwimigqomo evaliweyo kwaye ukhusele ekukhanyeni kunye nomswakama |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | I-Active Pharmaceutical ingredient (API) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we-Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) kunye nomgangatho ophezulu.
Irinotecan Hydrochloride Trihydrate yi inhibitor ye-topoisomerase I ikakhulu esetyenziselwa ukunyanga umhlaza wekoloni kunye nomhlaza we-rectal, ukuthintela ukuxhomekeka kwe-DNA strand ngokuzibophelela kwi-topoisomerase I-DNA complex.I-lrinotecan hydrochloride, i-semi-synthetic, ephuma emanzini ephuma kwi-agent anticancer enamandla i-camptothecin, yaziswa eJapan kunyango lwemiphunga, i-ovarian, kunye nomhlaza womlomo wesibeleko.I-lrinotecan yenza umsebenzi wayo we-antitumor nge-inhibition ye-topoisomerase I, i-enzyme yeselula ebandakanyekayo ekugcineni i-topographic structure ye-DNA ngexesha lenkqubo yokuguqulela, ukukhutshelwa, kunye ne-mitosis.I-lrinotecan idlula kwi-de-esterification kwi-vivo ukuze ivelise i-metabolite esebenzayo, i-SN-38, ephindwe ka-1000 inamandla ngaphezu komzali.Nangona inetyhefu encinci kune-camptothecin, inani elibalulekileyo lezigulana kulingo lwezonyango libonise iziphumo ebezingalindelekanga ze-leukopenia, urhudo, isicaphucaphu, kunye ne-alopecia.Unyango oludityanisiweyo lwe-irinotecan kunye nenye iarhente ye-anticancer esetyenziswa ngokubanzi, i-cisplatin, kuxelwe ukuba yongamile kune-arhente yodwa.I-lrinotecan ikulingo lwezonyango lwesisu, ibele, isikhumba, i-colorectal, i-pancreatic cancers, i-mesothelioma kunye ne-non-Hodgkin's lymphoma.
