Ketorolac Tromethamine CAS 74103-07-4 Ubunyulu >99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we-Ketorolac Tromethamine Salt (CAS: 74103-07-4) enomgangatho ophezulu.Sinokubonelela nge-COA, ukuhanjiswa kwehlabathi jikelele, ubuninzi obuncinci kunye nobuninzi obukhoyo.Ukuba unomdla kule mveliso, nceda uthumele ulwazi oluneenkcukacha lubandakanya inombolo ye-CAS, igama lemveliso, ubuninzi kuthi.Please contact: alvin@ruifuchem.com
| Igama leMchiza | Ketorolac Tromethamine |
| Izithethantonye | Ketorolac Tris Ityuwa;I-Ketorolac (iTyuwa yeTromethamine);rac Ketorolac Tromethamine Ityuwa;iToradol;(±) -5-Benzoyl-2,3-Dihydro-1H-Pyrrolizine-1-Carboxylic Acid Tris Ityuwa;(±) -Ifomu yeTromethamine yeTyuwa |
| Inombolo yeCAS | 74103-07-4 |
| Ubume beStokhwe | Kwi-Stock, Kwenziwa uRhwebo |
| Ifomula yeemolekyuli | C15H13NO3·C4H11NO3 |
| Ubunzima beMolekyuli | 376.41 |
| Indawo yokunyibilika | 160.0 ~ 161.0℃ |
| Indawo yokubilisa | 493.2℃ ku-760 mmHg |
| Inovakalelo | Hygroscopic.Ukukhanya okunovelwano |
| λmax | 322nm(MeOH)(lit.) |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder |
| pH | 5.7~6.7 |
| Indawo yokunyibilika | 160.0 ~ 161.0℃ |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
| Indlela yoVavanyo / yoHlahlelo | 98.5 ~ 101.5% (Ibalwe kwiSisekelo esomileyo) |
| Ilahleko ekomisweni | <0.50% |
| Intsalela kwi-Ignition | <0.10% |
| Iintsimbi ezinzima (Pb) | ≤20ppm |
| Izinto ezinxulumeneyo | |
| Ukungacoceki RRT0.54 | <0.50% |
| Ukungcola RRT0.66 | <0.50% |
| Ketorolac 1-Keto Analog | <0.10% |
| Ketorolac 1-Hydroxy Analog | <0.10% |
| Nakuphi na Okunye Ukungcola Okukodwa | <0.20% |
| Ukungcola ngokupheleleyo | <1.00% |
| Izinyibilikisi ezishiyekileyo | |
| Dichloroethane | <50ppm |
| IEthanol engenamanzi | <5000ppm |
| Imida yeMicroorganism | |
| Isixa seBhaktheriya | <1000cfu/g |
| Isixa sokungunda kunye negwele | <100cfu/g |
| Escherichia.Coli | Ukungabikho |
| I-Endotoxin yebhaktiriya | <5EU/mg |
| I-Infrared Spectrum | Iyahambelana neSakhiwo |
| Ukunyibilika kwi-H2O | AyinaMbala ukuya kuMthubi ecacileyo (15 mg/ml) Ukupasa |
| Umgangatho woVavanyo | Umgangatho woShishino |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwisitya esivaliweyo.Gcina kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engenamoya kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
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Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
I-Ketorolac Tromethamine Ityuwa (i-CAS: 74103-07-4) i-agent ye-anti-inflammatory nonsteroidal ebonisa umsebenzi we-analgesic kunye ne-antipyretic.I-COX inhibitor engakhethiyo kunye ne-IC50s ye-20 nM zombini i-COX-1 kunye ne-COX-2.I-Ketorolac Tromethamine Ityuwa iyasebenza ekulawuleni okuphakathi ukuya kwiintlungu ezinzima emva kokuhlinzwa.Nangona kunjalo, yeyokuqala yolu hlobo lwe-agent ukuba isetyenziswe ngumzali njenge-analgesic kwaye ibonakaliswe ngokukodwa kwinaliti ye-intramuscular.I-Ketorolac imele enye indlela eluncedo kwi-narcotic analgesics ngenxa yokungabikho kokusetyenziswa kakubi.Isetyenziselwa ikakhulu kwiziphumo zayo ze-analgesic kunyango lwexesha elifutshane lwentlungu ethambileyo ukuya ephakathi kwizinja kunye neempuku.Ubude besiphumo se-analgesic kwizinja malunga neeyure ze-8-12, kodwa ngenxa yokufumaneka kwe-NSAID ezivunyiweyo, ezikhuselekileyo ezinjeni, ukusetyenziswa kwayo kuyathandabuzeka.Ityuwa ye-organoammonium evela kumxube weemali ezilinganayo ze-ketorolac kunye ne-tromethamine (tris).Inefuthe elinamandla le-analgesic elingena-seating kunye ne-moderate anti-inflammatory effects.Isetyenziswa kulawulo lwexeshana elifutshane leentlungu zasemva kotyando, nakumathontsi esweni ukuze kuthomalaliswe ukurhawuzelelwa kwe-ocular okunxulumene ne-seasonal allergic conjunctivitis.
Iimpawu zeHazard T - zinetyhefu
Iikhowudi zoMngcipheko
I-R25 - Inetyhefu xa iginyiwe
R36/37/38 - Ukucaphukisa emehlweni, inkqubo yokuphefumla kunye nolusu.
I-R23/24/25 - Ityhefu ngokuphefumla, xa udibana nesikhumba kwaye xa uginyiwe.
Inkcazelo yoKhuseleko
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S45 - Kwimeko yengozi okanye ukuba uziva ungaphilanga, funa ingcebiso kagqirha ngokukhawuleza (bonisa ileyibhile nanini na kunokwenzeka.)
S36/37/39 - Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo / ubuso.
Ii-ID ze-UN UN 2811 6.1/PG 3
WGK eJamani 3
RTECS UY7759900
Ikhowudi yeHS 2933995500
Udidi lweeNgozi 6.1(a)
Ukupakisha Iqela II
I-Ketorolac Tromethamine iqulethe ngaphantsi kweepesenti ze-98.5 kwaye ingabi ngaphezu kwe-101.5 ipesenti ye-C15H13NO3 · C4H11NO3, ibalwa kwisiseko esomileyo.
Ukupakishwa kunye nokugcinwa-Londoloza kwimigqomo eqinile, ekwazi ukumelana nokukhanya.Gcina kwi-25 °, uhambo oluvunyelwe phakathi kwe-15 ° kunye ne-30 °
Imigangatho yezalathiso ye-USP <11>-
USP Ketorolac Tromethamine RS
Isazisi-
A: I-Infrared Absorption <197K>.
B: Ukufunxwa kwe-Ultraviolet <197U>-
Isisombululo: 10 µg ngemL
Phakathi: i-methanol.
C: Uvavanyo lwe-Tromethamine-Lungisa isisombululo esiPhakathi se-USP Ketorolac Tromethamine RS kumxube we-dichloromethane kunye ne-methanol (2: 1) equkethe i-5 mg nge-mL.Ngokufanayo lungiselela isisombululo sovavanyo lwe-Ketorolac Tromethamine equlethe i-5 mg nge-mL.Faka imithamo ye-40-µL yoMgangatho wesisombululo kunye nesisombululo sovavanyo kwipleyiti ecekethekileyo yechromatographic (bona iChromatography <621>) eqatywe nge-0.25-mm yomaleko we-chromatographic silica gel umxube.Beka ipleyiti kwigumbi le-chromatographic ngaphambili elilinganiswe nomxube we-dichloromethane, i-acetone, kunye ne-glacial acetic acid (95: 5: 2).Vala igumbi, kwaye uphuhlise ichromatogram de umphambili we-solvent uhambe malunga nesithathu-kwesine sobude bepleyiti.Susa ipleyiti kwigumbi, kwaye uvumele i-solvent ibe ngumphunga.Gcoba ipleyiti ngesisombululo esinxilisayo esisanda kulungiswa esine-30 mg ye-ninhydrin nge-mL, kwaye ushushu iplate malunga ne-150 ° kwimizuzu emi-2 ukuya kwemi-5.Amabala aphuzi anepinki ukuya kwimida emfusa aphuhlisa kwipleyiti kwiindawo apho isisombululo soMgangatho kunye nesisombululo sovavanyo sisetyenzisiwe.
pH <791>: phakathi kwe-5.7 kunye ne-6.7, kwisisombululo (i-1 kwi-100).
Ilahleko ekomisweni <731>-Yomise kwi-vacuum kwi-60 ° kwiiyure ze-3: ilahlekelwa ngaphezu kwe-0.5% yobunzima bayo.
Intsalela ekutshisweni <281>: hayi ngaphezulu kwe-0.1%.
Iintsimbi ezinzima, Indlela II <231>: 0.002%.
Ukucoceka kweChromatographic-
Isigaba seselula, umxube we-Solvent, ukulungiswa koMgangatho, isisombululo seSisombululo, kunye nenkqubo yeChromatographic-Qhubeka njengoko kuyalelwe kwi-Assay.
Isisombululo sovavanyo-Sebenzisa ukulungiswa koVavanyo.
Inkqubo-iChromatograph isisombululo soVavanyo njengoko kuqondiswe kwiNkqubo kwi-Assay, evumela ukuba i-chromatography yandise amaxesha amathathu okugcinwa kwexesha le-ketorolac.Linganisa iimpendulo zazo zonke iincopho.Bala ipesenti yokungahlambuluki komntu ngamnye kwinxalenye yeKetorolac Tromethamine ethathwe ngefomula:
I-100rfi (ri / rs)
apho i-rfi yimeko yokuphendula yencopho yokungcola komntu ngamnye xa kuthelekiswa naleyo ye-ketorolac;ri yincopho impendulo yokungahlambuluki ngakunye;kwaye rs sisimbuku sazo zonke iincopho zeempendulo zeencopho zokungacoceki kunye neyona ndawo inkulu ye-ketorolac.Amaxabiso e-rfi yi-0.52 ye-analog ye-ketorolac 1-keto, i-0.67 ye-analog ye-ketorolac 1-hydroxy, i-2.2 yencopho yokungcola enexesha lokugcinwa kwe-0.54 ngokumalunga ne-ketorolac, kunye ne-0.91 yencopho yokungcola ngexesha lokugcinwa. ye 0.66.Akukho ngaphezu kwe-0.1% ye-ketorolac 1-keto analog okanye i-ketorolac 1-hydroxy analog ifunyenwe;hayi ngaphezulu kwe-0.5% yako nakuphi na okunye ukungcola okufunyenweyo;kwaye isixa sabo bonke ukungcola akukho ngaphezu kwe-1.0%.
Isivavanyi-
I-Mobile phase-Dissolve 5.75 g ye-monobasic ammonium phosphate kwi-1000 mL yamanzi, kwaye ulungelelanise ne-phosphoric acid kwi-pH ye-3.0.Lungiselela umxube ohluziweyo kunye ne-degassed yesi sisombululo se-buffer kunye ne-tetrahydrofuran (70:30).Yenza uhlengahlengiso xa kuyimfuneko (jonga ukufaneleka kweNkqubo phantsi kweChromatography <621>) ukufezekisa ixesha lokugcinwa kwe-ketorolac malunga ne-8 ukuya kwi-12 imizuzu.
Umxube we-solvent-Lungisa umxube wamanzi kunye ne-tetrahydrofuran (70:30).
Ukulungiswa okusemgangathweni-Nyibilikisa ngokobungakanani isixa esinobunzima obuchanekileyo be-USP Ketorolac Tromethamine RS kumxube weSolvent ukufumana isisombululo esinoxinzelelo olwaziwayo malunga ne-0.4 mg nge-mL.[QAPHELA-Khusela esi sisombululo ekukhanyeni.]
Ukulungiswa kwe-Assay-Transfer malunga ne-20 mg ye-Ketorolac Tromethamine, ilinganiswe ngokuchanekileyo, kwi-flask ye-volumetric ye-50-mL, xuba ngomxube we-Solvent ukuya kwivolumu, kwaye udibanise.[QAPHELA-Khusela esi sisombululo ekukhanyeni.]
Isisombululo sesisombululo-Kumxube we-250-mL we-separator 100 mL yamanzi, i-100 mL ye-dichloromethane, i-30 mg ye-USP Ketorolac Tromethamine RS, kunye ne-1 mL ye-1 N hydrochloric acid.Faka isivalo, xukuxa, kwaye uvumele iileya ukuba zahlukane.Dlulisa umaleko we-dichloromethane esezantsi kwiflask yeglasi ye-borosilicate emisiweyo, kwaye ulahle umaleko ongaphezulu.Veza isisombululo se-dichloromethane ekukhanyeni kwelanga kwimizuzu eyi-10 ukuya kwe-15.Dlulisa i-1.0 mL yesisombululo kwi-vial, umphunga emoyeni wangoku okanye kumlambo we-nitrogen ukuya komile, yongeza i-1.0 mL yomxube we-Solvent, kwaye ujikeleze ukuze unyibilike.[QAPHELA-Esi sisombululo sinokugcinwa phantsi kwesikhenkcezisi kwaye sisetyenziswe nje ukuba ichromatogram ifunyenwe njengoko iqondiswe kwiNkqubo ifanelekile ukuchonga iincopho ngenxa ye-analog ye-ketorolac 1-keto kunye ne-ketorolac 1-hydroxy analog, kunye nomlinganiselo wesisombululo. phakathi kwe-ketorolac 1-keto analog kunye ne-ketorolac.]
Inkqubo yeChromatographic (bona i-Chromatography <621>)—I-chromatograph yolwelo ixhotyiswe nge-313-nm detector kunye nekholamu ye-4.6-mm × 25-cm equlethe i-5-µm yokupakisha i-L7 kwaye igcinwe kwiqondo lokushisa elingaguqukiyo malunga ne-40 °.Izinga lokuhamba malunga ne-1.5 mL ngomzuzu.I-Chromatograph isisombululo seSigqibo, kwaye urekhode iimpendulo eziphezulu njengoko ziqondiswe kwiNkqubo: amaxesha okugcinwa okuhambelanayo malunga ne-0.63 ye-ketoroac 1-hydroxy analog, i-0.89 ye-ketorolac 1-keto analog, kunye ne-1.0 ye-ketorolac;kunye nesisombululo, R, phakathi kwe-ketorolac 1-keto analog kunye ne-ketorolac ayikho ngaphantsi kwe-1.5.I-Chromatograph Ukulungiswa koMgangatho, kwaye urekhode iimpendulo eziphakamileyo njengoko ziqondiswe kwiNkqubo: ukusebenza kakuhle kwekholomu akukho ngaphantsi kweeplati zethiyori ezingama-5500;kunye nokutenxa komgangatho ozalanayo wokuphindaphinda iinaliti akukho ngaphezu kwe-1.5%.
Inkqubo-Ngokwahlukileyo tofa imithamo elinganayo (malunga ne-10 µL) yolungiselelo loMgangatho kunye nolungiselelo loVavanyo kwichromatograph, urekhode iichromatograms, kwaye ulinganise iimpendulo zeencopho ezinkulu.Bala ubuninzi, kwi-mg, ye-C15H13NO3 · C4H11NO3 kwinxalenye ye-Ketorolac Tromethamine ethathwe ngefomula:
50C(rU / rS)
apho i-C igxininise, kwi-mg nge-mL, ye-USP Ketorolac Tromethamine RS kulungiselelo oluMgangatho;kunye ne-rU kunye ne-rS ziimpendulo zencopho ye-ketorolac ezifunyenwe kulungiselelo lwe-Assay kunye nokulungiswa koMgangatho, ngokulandelelanayo.
