L-Tryptophan CAS 73-22-3 (H-Trp-OH) Uvavanyo 98.5 ~ 101.5% Umgangatho ophezulu weFactory
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we-L-Tryptophan (H-Trp-OH; Trp okanye W) (CAS: 73-22-3) kunye nomgangatho ophezulu.Njengomnye wabathengisi abakhulu be-amino acids e-China, i-Ruifu Chemical inikezela nge-amino acids ukuya kwimigangatho yamazwe ngamazwe, njenge-AJI, i-USP, i-EP, i-JP kunye nemigangatho ye-FCC.Sinokubonelela nge-COA, ukuhanjiswa kwehlabathi jikelele, ubuninzi obuncinci kunye nobuninzi obukhoyo.Ukuba unomdla kwi-L-Tryptophan,Please contact: alvin@ruifuchem.com
| Igama leMchiza | L-Tryptophan |
| Izithethantonye | H-Trp-OH;L-(-)-Tryptophan;(-)-Tryptophan;i-tryptophan;L-Trp;I-Trp efinyeziweyo okanye i-W;(S)-(-)-2-Amino-3-(3-Indolyl)propionic Acid;I-L-α-Amino-3-Indolepropionic Acid;I-2-Amino-3- (1H-Indol-3-yl) ipropanoic Acid |
| Ubume beStokhwe | KwiSitokhwe, Umthamo weMveliso 3000 yeeToni ngonyaka |
| Inombolo yeCAS | 73-22-3 |
| Ifomula yeemolekyuli | I-C11H12N2O2 |
| Ubunzima beMolekyuli | 204.23 |
| Indawo yokunyibilika | 282℃(dec.)(lit.) |
| Ukuxinana | 1.34 |
| Ukunyibilika kwamanzi | Inyibilika kancinane emanzini, 11.4 g/l 25℃ |
| Ukunyibilika | Inyibilika kancinane kwi-Ethanol.Kancinci kakhulu ukuNyibilika etywaleni.Ayinyibilikiyo kwi-Ether, iChloroform |
| Uzinzo | Izinzile.Ayihambelani ne-Acids eyomeleleyo, ii-Agents eziOxidizing ezinamandla |
| Ugcino Temp. | Itywinwe kwindawo eyomileyo, ubushushu beGumbi |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Ukuhlelwa | IiAmino Acids kunye nezinto eziphuma kuyo |
| Uphawu | Ruifu Chemical |
| Iikhowudi zeNgozi | Xi | RTECS | YN6130000 |
| Iingxelo zoMngcipheko | 33-40-62-41-37/38-36/37/38-22 | F | 8 |
| Iingxelo zoKhuseleko | 24/25-36/37/39-36-26 | I-TSCA | Ewe |
| WGK eJamani | 2 | Ikhowudi ye-HS | 2922491990 |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Iikristale eziMhlophe okanye umgubo weCrystalline | Iyahambelana |
| Ukuchongwa | Iyahlangabezana neeMfuno | Iyahambelana |
| Ukujikeleziswa okuthe ngqo [α]20/D | -30.5° ukuya -32.5° (C=1,H2O) | -31.5 ° |
| Imeko yesisombululo | ≥95.0% (Ugqithiso) | 96.7% |
| Ikloridi (Cl) | ≤0.020% | <0.020% |
| Isulfate (SO4) | ≤0.020% | <0.020% |
| I-Ammonium (NH4) | ≤0.020% | <0.020% |
| Intsimbi (Fe) | ≤20ppm | Iyahambelana |
| Iintsimbi ezinzima (Pb) | ≤10ppm | Iyahambelana |
| IArsenic (As2O3) | ≤1.0ppm | Iyahambelana |
| Ezinye iiAmino Acids | Iyahlangabezana neMfuneko | Iyahambelana |
| Ilahleko ekomisweni | ≤0.20% (kwi-105℃ kwiiyure ze-3) | 0.16% |
| Intsalela ekutshisweni (iSulfated) | ≤0.10% | 0.04% |
| Isivavanyi | 98.5~101.0% | 99.7% |
| pH | 5.4~6.4 (1.0g kwi-100ml ye-H2O ) | 5.8 |
| Ukungcola okuguquguqukayo kwe-Organic | Iyahlangabezana neMfuneko | Iyahambelana |
| IProjeni | Nonpyrogenic | Iyahambelana |
| Ukuqukumbela: Le Mveliso ngokuHlolwa ngokuVumelana noMgangatho we-EP5, AJI97, USP35 | ||
L-Tryptophan (H-Trp-OH) (CAS: 73-22-3) AJI 97 Indlela yoVavanyo
Ukuchonga: Thelekisa i-spectrum ye-infrared yokufunxa yesampuli kunye neyomgangatho we-potassium bromide disc method.
Ukujikeleza okuKhethekileyo [α]20/D: Isampulu eyomileyo, C=1, H2O inyibilika ngokufudumeza
I-State of Solution (i-Transmittance): 0.5g kwi-20ml ye-2 mol / L HCl, i-spectrophotometer, i-430nm, i-10mm ubukhulu beseli.
I-Chloride (Cl): 0.7g, A-1, ref: 0.40ml ye-0.01mol/L HCl
I-Ammonium (NH4): B-2
I-Sulfate (SO4): 1.2g, (1), i-ref: 0.50ml ye-0.005mol/L H2SO4
Intsimbi (Fe): 0.75g, (2), ref: 1.5ml ye-Iron Std.(0.01mg/ml)
Iintsimbi ezinzima (Pb): 2.0g, (4), ref: 2.0ml yePb Std.(0.01mg/ml)
Arsenic (As2O3): 2.0g, (1), ref: 2.0ml ye-As2O3 Std.
Ezinye ii-Amino Acids: H2O, Dibanisa ngokufudumeza (40℃) Isampulu yovavanyo: 50μg, A-6-a, ulawulo: L-Trp 0.25μg
Ilahleko ekomisweni: kwi-105℃ kwiiyure ezi-3.
Intsalela kwi-Ignition (Sulfated): Uvavanyo lwe-AJI 13
I-Assay: Isampulu eyomileyo, i-200mg, (1), i-3ml ye-formic acid, i-50ml ye-glacial acetic acid, i-0.1mol / L HCLO4 1ml = 20.423mg C11H12N2O2
Uvavanyo lwe-pH: 1.0g kwi-100ml ye-H2O
I-L-Tryptophan (H-Trp-OH) (CAS: 73-22-3) Indlela yoVavanyo ye-USP35
INGCACISO
I-Tryptophan iqulethe i-NLT 98.5% kunye ne-NMT 101.5% ye-C11H12N2O2, njenge-L-Tryptophan, ibalwe ngokomisiweyo.
UKUCHAZA
A. UKUFUTSHWA KWE-IFRARED <197K>
UVAVANYO
INKQUBO
Isampuli yesisombululo: Beka i-200 mg ye-Tryptophan kwi-flask ye-125-mL.Ukunyibilika kumxube we-3 mL ye-formic acid kunye ne-50 mL ye-glacial acetic acid.
Uhlalutyo: I-Titrate kunye ne-0.1 N perchloric acid VS, imisela i-endpoint potentiometrically.Yenza ukuzimisela okungenanto, kwaye wenze naluphi na ulungiso oluyimfuneko (jonga i-Titrimetry <541>).I-mL nganye ye-0.1 N perchloric acid ilingana ne-20.42 mg ye-C11H12N2O2.
Iinqobo zokwamkela: 98.5% ~ 101.5% kwisiseko esomileyo
UBUNGCOLA
Ukungcola Kwezinto Eziphilayo
OKUSHIYELWE OKUSHIYELWE <281>: NMT 0.1%
I-CHLORIDE NE-SULFATE, I-Chloride <221>: Isahlulo se-0.73-g asibonakalisi i-chloride ngaphezu kokuhambelana ne-0.50 mL ye-0.020 N i-hydrochloric acid (0.05%).[QAPHELA-Cwangcisa ngobunono ulungiselelo lwesampulu ukuze lunyibilike, ukuba kuyimfuneko.]
I-CHLORIDE NE-SULFATE, i-Sulfate <221>: Ingxenye ye-0.33-g ibonisa ukuba akukho sulfate ngaphezu kokuhambelana ne-0.10 mL ye-0.020 N sulfuric acid (0.03%).[QAPHELA-Cwangcisa ngobunono ulungiselelo lwesampulu ukuze lunyibilike, ukuba kuyimfuneko.
I-IRON <241>: NMT 30ppm
IIMETALI EZISINZI, Indlela II <231>: NMT 15ppm
Ukungcola Okuphilayo
INKQUBO 1
Isisombululo A: I-Trifluoroacetic acid emanzini (1 mL/L)
Isisombululo B: I-Trifluoroacetic acid kwi-acetonitrile kunye nesisombululo samanzi (80:20) (1 mL / L isisombululo se-trifluoroacetic acid)
Isisombululo esisemgangathweni: 1.0 mg / L nganye ye-USP Tryptophan Related Compound A RS kunye ne-USP Tryptophan Related Compound B RS emanzini
Isisombululo sesampuli: 10.0 mg / mL ye-tryptophan emanzini
Isisombululo sokufaneleka kwenkqubo: 1.0 mg/L ye USP Tryptophan Related Compound B RS emanzini
Isigaba esiphathwayo: Bona itheyibhile yodidi olungezantsi.
| Ixesha (min) | Isisombululo A (%) | Isisombululo B (%) |
| 0 | 95 | 5 |
| 2 | 95 | 5 |
| 37 | 35 | 65 |
| 42 | 0 | 100 |
| 47 | 0 | 100 |
| 50 | 95 | 5 |
| 60 | 95 | 5 |
Inkqubo yeChromatographic (Jonga iChromatography <621>, Ukufaneleka kweNkqubo.)
Indlela: LC
Umtshina: UV 220 nm
Ikholomu: 4.6-mm × 25-cm;5-µm ukupakisha i-L1
Ubushushu bekholamu: 30 °
Izinga lokuhamba: 1 mL / min
Ubungakanani betofu: 20 µL
Ukufaneleka kwenkqubo
Isampulu: Isisombululo sokufaneleka kwenkqubo
Imfuneko yokufaneleka
Ukutenxa umgangatho ozalanayo: NMT 5.0%
Uhlalutyo
Iisampulu: Isisombululo esisemgangathweni kunye nesisombululo seSampuli
Bala ipesenti yokungcola okungachazwanga kwisahlulo seTryptophan esithathiweyo:
Isiphumo = (rU/rS) × (CS/CU) × 100
I-rU = indawo ephezulu yokungcola okungachazwanga kwiSampuli yesisombululo
rS = indawo ephezulu ye-tryptophan enxulumene nekhompawundi B kwisisombululo esiPhakathi
CS = ukuxinwa kwe-USP Tryptophan Related Compound B RS kuMgangatho wesisombululo (µg/mL)
CU = uxinaniso lweTryptophan kwiSampuli yesisombululo (µg/mL)
Iinqobo zokwamkelwa
Ubumdaka bubonke 1: NMT 0.01% yokungcola okupheleleyo okuphumayo phambi kwencopho ye-tryptophan
Ubumdaka bubonke 2: NMT 0.03% yokungcola okupheleleyo emva kwencopho ye-tryptophan.[QAPHELA-Ungafaki incopho ye-tryptophan enxulumene nekhompawundi B.]
Ikhompawundi enxulumene ne-Tryptophan A: Ukuba incopho ye-tryptophan enxulumene nekhompawundi A ibonwa kwisisombululo seSampule, emva koko wenze uvavanyo lweNkqubo yesi-2: Umda we-Tryptophan Related Compound A, ngezantsi.
INKQUBO YESI-2: UMDA WECOMPOUND ENXULUMENE NE-TRYPTOPHAN A
Isisombululo A: 18 mM monobasic sodium phosphate, ehluziweyo kunye ne-degassed (pH 2.5), kunye ne-acetonitrile (9: 1)
Isisombululo B: 10 mM monobasic sodium phosphate, ehluziweyo kunye ne-degassed (pH 2.5), kunye ne-acetonitrile (1: 1)
Isisombululo C: IAcetonitrile emanzini (7:3)
Isisombululo esisemgangathweni: 0.1 mg / L ye-USP Tryptophan Related Compound A RS emanzini
Isisombululo sesampuli: 10.0 mg / mL ye-Tryptophan emanzini
Isigaba esiphathwayo: Bona itheyibhile yodidi olungezantsi
| Ixesha (min) | Isisombululo A (%) | Isisombululo B (%) | Isisombululo C (%) |
| 0 | 100 | 0 | 0 |
| 30 | 44 | 56 | 0 |
| 30.1 | 0 | 0 | 100 |
| 45 | 0 | 0 | 100 |
| 45.1 | 100 | 0 | 0 |
| 60 | 100 | 0 | 0 |
Inkqubo yeChromatographic
(Jonga iChromatography <621>, Ukufaneleka kweNkqubo.)
Indlela: LC
Umtshina: UV 216 nm
Ikholamu: 3.9-mm × 15-cm;5-µm ukupakisha i-L1
Ubushushu bekholamu: 30 °
Izinga lokuhamba: 1 mL / min
Ubungakanani betofu: 20 µL
Ukufaneleka kwenkqubo
Isampulu: Isisombululo esisemgangathweni
Imfuneko yokufaneleka
Ukutenxa umgangatho ozalanayo: NMT 5.0%
Uhlalutyo
Iisampulu: Isisombululo esisemgangathweni kunye nesisombululo seSampuli
Bala ipesenti yekhompawundi enxulumene ne-tryptophan
A kwisahlulo seTryptophan esithathiweyo:
Isiphumo = (rU/rS) × (CS/CU) × 100
I-rU = indawo ephezulu ye-tryptophan ehambelana nekhompawundi A kwisisombululo seSampuli
rS = indawo ephezulu ye-tryptophan ehambelana nekhompawundi A kwisisombululo esiPhakathi
CS = ukuxinwa kwe-USP Tryptophan Related Compound A RS kwisisombululo esiPhakathi (µg/mL)
CU = uxinaniso lweTryptophan kwiSampuli yesisombululo (µg/mL)
Indlela yolwamkelo: NMT 10 ppm
IIMVAVANYO EZITHILE
UKUJONGA KOMBONISO, ukuJikeleka okuthe ngqo <781S>: -29.4° ukuya -32.8°
Isisombululo sesampuli: 10 mg / mL, emanzini.[QAPHELA-Fundisa ngobunono ukunyibilika, ukuba kuyimfuneko.]
PH <791>: 5.5 ~ 7.0, kwisisombululo (1 kwi-100)
UKULAHLEKO EKOMISENI <731>: Yomisa isampuli kwi-105° kangange-3 h: ilahlekelwa yi-NMT nge-0.3% yobunzima bayo.
IIMFUNO EZONGEZELELWEYO
UKUPAKISHWA NOKUGCINWA: Gcina kwizikhongozeli ezivalwe kakuhle
IMIGANGATHO YE-USP REFERENCE <11>
USP L-Tryptophan RS
USP Tryptophan Related Compound A RS
3,3′-[Ethylidenebis(1H-indole-1,3-diyl)]bis[2S)-2-aminopropanoic]asidi.C24H26N4O4 432.49
USP Tryptophan Related Compound B RS
I-2-Acetamido-3- (1H-indol-3-yl) ipropanoic acid.C13H14N2O3 246.3
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Iimpawu zeHazard Xi - Irritant
Iikhowudi zoMngcipheko R33 - Ingozi yeziphumo ezongezelekayo
R40 - Ubungqina obuncinci besiphumo somhlaza
I-R62 - Umngcipheko onokubakho wokuphazamiseka kokuchuma
R41 - Umngcipheko womonakalo omkhulu emehlweni
I-R37/38 - Iyacaphukisa inkqubo yokuphefumla kunye nolusu.
R36/37/38 - Ukucaphukisa emehlweni, inkqubo yokuphefumla kunye nolusu.
I-R22 - Iyingozi xa iginyiwe
Inkcazo yoKhuseleko S24/25 -Kuphephe ukudibana nolusu namehlo.
S36/37/39 - Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo / ubuso.
S36 - Nxiba iimpahla ezifanelekileyo zokukhusela.
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
I-L-Tryptophan (H-Trp-OH) (i-CAS: 73-22-3) iyimfuneko ye-amino acid ekukhuleni kwezilwanyana ezincinci kwaye iyona nto iphambili i-amino acids esetyenziselwa ukutya emva kwe-lysine, i-methionine kunye ne-threonine.Ukongeza i-tryptophan kunokuphucula ukusebenza kakuhle kwee-amino acids, ukonyusa ukutya, ukukhuthaza ukukhula kunye nokuphucula ukungakhuseleki.Uxinzelelo lwamantshontsho ehagu emva kokuba elunyulwe lunokuthomalalisa kwaye ukuzala kungaphuculwa ngetryptophan, esetyenziswa kakhulu kwisondlo.Izongezo zesondlo.Icandelo elibalulekileyo lokunyuswa kwe-amino acid kunye namalungiselelo abanzi e-amino acid.Inokunyanga ukunqongophala kwe-niacin.Isetyenziswe kuphando lwe-biochemical, njenge-sedative kumayeza.Uluntu: isongezelelo sesondlo.antioxidant.I-Tryptophan yi-precursor ye-5-hydroxytryptamine, i-neurotransmitter ebalulekileyo emzimbeni womntu.Yenye yee-amino acids ezibalulekileyo zomzimba womntu;Izongezo zesondlo kubasetyhini abakhulelweyo kunye nomgubo okhethekileyo wobisi kubantwana abancinci;Iziyobisi zonyango lokunqongophala kwe-niacin (pellagra);Njengesithomalalisi, siyakwazi ukulawula isigqi sengqondo kunye nokuphucula ukulala.Izilwanyana: khuthaza ukutya kwezilwanyana, nciphisa ukuphendula koxinzelelo, ukuphucula ukulala kwezilwanyana, ukwandisa amajoni omzimba omntwana kunye nosana kunye nokuphucula ukuncancisa kwezilwanyana zobisi.Nciphisa umthamo weprotheyini ekwikhwalithi ephezulu yokutya, wonge iindleko zesondlo, unciphise umthamo weprotheyini yokutya, kwaye wonge indawo yobisi olungumgubo.Isicelo malunga ne-L-Tryptophan: I-L-Tryptophan luhlobo lwezongezelelo zesondlo.I-L-Tryptophan inokuphucula imetabolism ye-aerobic ye-muscle kwaye ikhulise kakhulu amandla emisipha kunye nokunyamezela ngokutya kuphela.I-L-Tryptophan ingasetyenziswa njengesixhasi sesondlo.I-L-Tryptophan yenye yezona zixhaso zidumileyo nezisebenzayo zezondlo kunye nemveliso eyimfuneko kubakhi bomzimba.
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