LCZ696 Intermediate CAS 1426129-50-1 Ubunyulu ≥98.0% (HPLC) ee ≥99.0% Factory High Purity
Ubonelelo ngezoRhwebo LCZ696 (CAS: 936623-90-4) abaPhakathi abaNxulumeneyo:
(R)-tert-Butyl (1-([1,1-biphenyl] -4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
I-AHU-377 (ityuwa ye-hemicalcium) I-CAS: 1369773-39-6
AHU-377;I-CAS ye-Sacubitril: 149709-62-6
I-LCZ696;Entresto;Umxube weSacubitril kunye neValsartan CAS: 936623-90-4
| Igama leMchiza | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate |
| Izithethantonye | I-LCZ696 ePhakathi |
| Inombolo yeCAS | 1426129-50-1 |
| Inombolo yeCAT | RF-PI169 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
| Ifomula yeemolekyuli | C20H25NO3 |
| Ubunzima beMolekyuli | 327.42 |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mhlophe ukuya kwi-Off-White Powder |
| Ubunyulu / Indlela yokuHlalutya | ≥98.0% (HPLC) |
| Ukugqithiswa kwe-Enantiomeric | ee: ≥99.0% |
| Ukufuma (KF) | ≤1.0% |
| Izinto ezinxulumeneyo A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Izinto ezinxulumeneyo B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Ezinye Izinto | ≤1.0% |
| Ukungcola ngokupheleleyo | ≤2.0% |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Phakathi kweLCZ696 (CAS: 936623-90-4) kunyango lwe-HFrEF |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
Umenzi onobunyulu obuPhezulu kunye noMgangatho oZinzile
Ubonelelo ngezoRhwebo LCZ696 (CAS: 936623-90-4) abaPhakathi abaNxulumeneyo:
(R)-tert-Butyl (1-([1,1-biphenyl] -4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
I-AHU-377 (ityuwa ye-hemicalcium) I-CAS: 1369773-39-6
AHU-377;I-CAS ye-Sacubitril: 149709-62-6
I-LCZ696;Entresto;Umxube weSacubitril kunye neValsartan CAS: 936623-90-4
I-LCZ696 lichiza lokulinga eliphuhliswe yi-Novartis Pharmaceutical yase-United States kunyango lwezigulane ezine-Heart Failure kunye nokunciphisa i-Ejection Fraction (HFrEF).Ukungaphumeleli kwentliziyo sisifo esisongela ubomi.Intliziyo yesigulana ayikwazi ukumpompa igazi elaneleyo lokubonelela umzimba, kwaye zibonakala iimpawu ze-dyspnea, ukukhathala kunye nokugcinwa kwamanzi ngokuthe ngcembe, ngoko ngokuthe ngcembe kwanda, kuchaphazela kakhulu umgangatho wobomi.I-LCZ696 inokunyusa ukhuseleko lwendalo lomzimba ngokuchasene nokungaphumeleli kwentliziyo, kunye nokwandisa inqanaba le-peptides ye-natriuretic kunye nezinye iipeptide ze-vasoactive endogenous, kunye nokuthintela inkqubo ye-renin-angiotensin-aldosterone (RAAS).I-LCZ696 idibene ne-Novartis's Hypertension Medication (i-Diovan, igama eliqhelekileyo: i-valsartan) kunye neyeza lovavanyo i-AHU-377.I-AHU377 ivala indlela yeepeptides ezimbini ezinoxanduva lokuthoba uxinzelelo lwegazi.I-Diovan iphucula i-vasodilatation kwaye ivuselela umzimba ukuba ukhuphe i-sodium kunye namanzi.
