Lenvatinib Mesylate Intermediate CAS 15568-85-1 Ubunyulu > 97.0% (HPLC) Factory
I-Ruifu Chemical Supply Lenvatinib Mesylate Intermediate with High Purity
Lenvatinib Mesylate CAS 857890-39-2
I-4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
I-Desquinolinyl Lenvatinib;I-1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5-(Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
I-4-Amino-3-Chlorophenol CAS 17609-80-2
I-4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4
Igama leMchiza | 5-(Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dione |
Izithethantonye | I-5-(i-Methoxymethylene) i-Meldrum's Acid;Ukungcola kweCabozantinib 56;Ukungcola kweLenvatinib 79 |
Inombolo yeCAS | 15568-85-1 |
Inombolo yeCAT | RF-PI1967 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C8H10O5 |
Ubunzima beMolekyuli | 186.16 |
Indawo yokunyibilika | 132.0 ~ 134.0℃ |
Ukuxinana | 1.297±0.06 g/cm3 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMthubi |
I-1 H NMR Spectrum | Ukungqinelana Nolwakhiwo |
Ubunyulu / Indlela yokuHlalutya | >97.0% (HPLC) |
Ukungcola ngokupheleleyo | <3.00% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Umbindi weLenvatinib Mesylate (CAS: 857890-39-2) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-5-(Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dione (CAS: 15568-85-1) iphakathi kweLenvatinib Mesylate (CAS: 857890-39-2).I-Lenvatinib isilwanyana somhlaza we-thyroid esakhiwe yi-Eisai Corporation yaseJapan (iKhowudi: E7080), eyingxenye ye-inhibitor ye-oral multi-receptor tyrosine kinase (RTK) kwaye inokuthintela umsebenzi we-kinase we-vascular endothelial growth factor (VEGF) i-Receptors VEGFR1 ( FLT1), VEGFR2 (KDR), kunye neVEGFR3 (FLT4).I-Lenvatinib inokuthintela ukubandakanyeka kwezinye ii-RTKs kwi-angiogenesis ye-pathological, ukukhula kwe-tumor, kunye nokuqhubela phambili komhlaza ngaphandle kwemisebenzi yabo eqhelekileyo yeselula kubandakanya i-fibroblast growth factor (FGF) receptors FGFR1, 2, 3, kunye ne-4;I-Platelet-derived growth factor receptor (PDGFR [alpha]), i-KIT, kunye ne-RET.[Izibonakaliso]: I-Lenvatinib ifanelekile kunyango lwezigulane zomhlaza we-thyroid wokuphindaphinda kwendawo okanye uhlobo lwe-metastasis, uhlobo lwe-progressivity kunye ne-radioactive iodine-refractory differentiated type.Ngomhla we-13 kaFebruwari, i-2015, i-US FDA ivume i-anticancer drug Lenvatinib kunyango lomhlaza we-thyroid.I-Lenvatinib yi-inhibitor ye-enzyme ejoliswe kwizinto ezininzi, ekwazi ukuthintela i-VEGFR2 kunye ne-VEGFR3 (i-vascular endothelial growth factor receptor).Igama lezorhwebo leLenvatinib yiLenvima.Ngomhla we-20 kaMeyi, i-2015, i-Arhente yeMithi yaseYurophu (EMA) ivume i-Lenvatinib yonyango lwe-invasive, indawo ehamba phambili okanye i-metastatic differentiated (i-papillary, i-follicular, uhlobo lwe-Hurthle) umhlaza we-thyroid (DTC).Kulingo, ixesha eliphakathi lokusinda kwizigulane ze-DTC ene-radioactive iodine-refractory enyangwa nge-Lenvatinib yayiziinyanga ezili-18 ngelixa ixabiso lezigulane ezithatha indawo ye-placebo ziinyanga ezi-3 kuphela.
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Lenvatinib Mesylate Intermediate CAS 15568-85-1...
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Lenvatinib Mesylate CAS 857890-39-2 Assay 98.0~...
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I-Desquinolinyl Lenvatinib CAS 796848-79-8 Ubunyulu...
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I-4-Amino-3-Chlorophenol CAS 17609-80-2 Lenvatini...
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I-4-Amino-3-Chlorophenol Hydrochloride CAS 52671-...
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I-4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 4...
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Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8...
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Lenvatinib Mesylate Intermediate CAS 205448-65-...
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I-Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylat...