Lesinurad (RDEA 594) CAS 878672-00-5 Ubunyulu > 99.5% (HPLC) Uvavanyo 98.0 ~ 102.0%
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili weLesinurad (RDEA 594) (i-CAS: 878672-00-5) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iLesinurad kunye nabaPhakathi,Please contact: alvin@ruifuchem.com
| Igama leMchiza | Lesinurad |
| Izithethantonye | 2-[[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio]Acetic Acid;2-[[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl] thio]-Acetic Acid;i-RDEA 594;I-RDEA-594;RDEA594;Zurampic |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 878672-00-5 |
| Ifomula yeemolekyuli | I-C17H14BrN3O2S |
| Ubunzima beMolekyuli | 404.28 g/mol |
| Indawo yokunyibilika | >171℃(ngoDisemba) |
| Ukuxinana | 1.72±0.10 g/cm3 |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Mhlophe ukuya kwi-Off-White Powder | I-Off-White Powder |
| Ukuchongwa | Ixesha lokugcinwa kwencopho enkulu yesisombululo sesampulu sihambelana nomgangatho wereferensi | Iyahambelana |
| Amanzi nguKarl Fischer | <0.50% | 0.14% |
| Intsalela kwi-Ignition | <0.10% | 0.03% |
| Iintsimbi ezinzima (Pb) | ≤10ppm | <10ppm |
| Izinto eziyeleleneyo (HPLC) | ||
| Ukungacoceki okukhulu okukodwa | <0.20% | 0.07% |
| Ukungcola ngokupheleleyo | <1.00% | 0.24% |
| Ubunyulu / Indlela yokuHlalutya | >99.5% (Ummandla weHPLC) | 99.76% |
| Isivavanyi | 98.0~102.0% | 99.6% |
| I-Infrared Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| NMR Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
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Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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I-Lesinurad (RDEA 594) (i-CAS: 878672-00-5) ivunyiwe yi-US Food and Drug Administration (FDA) ngoDisemba 22, 2015, kwaye yavunywa yi-Arhente yeMithi yaseYurophu (EMA) ngoFebruwari 18, 2016. Ikhompawundi yaphuhliswa ngaphambili yiArdea.I-AstraZeneca yafumana inkampani kwi-2012, eyathi yafumana imveliso.Igama lokurhweba leli chiza yiZurampic® eMelika nakwiManyano yaseYurophu.I-Lesinurad yi-inhibitor yokuqala evunyiweyo ye-urate reuptake transporter (URAT1) yehlabathi, idibene ne-xanthine oxidase inhibitors ukunyanga i-gout ehlobene ne-hyperuricemia.
Lesinurad, igama lorhwebo Zurampic.I-Lesinurad ngokudibanisa ne-xanthine oxidase inhibitor (XOI) ye-hyperuricemic gout syndrome.Indlela yokusebenza kwayo kukunceda izintso zikhuphe i-uric acid, kwaye isebenza ngokuthintela umsebenzi wabathuthi ababandakanyekayo kwi-uric acid reabsorption kwizintso.
I-Lesinurad inqanda umsebenzi wothutho we-uric acid (IC50 = 3.36 μM) ye-hURAT1 (i-URAT1 yabantu), engaphezulu kwamaxesha angama-20 impembelelo yokuthintela kwi-rURAT1 (i-rat URAT1) (IC50 = 74.84 μM).I-Lesinurad inhibitha i-hURAT1 ngokusebenzisana kwe-amino acid engundoqo eseleyo Phe365.
