Letrozole CAS 112809-51-5 API Factory Aromatase Inhibitor II High Quality
Ukubonelela ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leKhemikhali: Letrozole
CAS: 112809-51-5
Aromatase Inhibitor II
Umgangatho ophezulu we-API, iMveliso yoRhwebo
| Igama leMchiza | Letrozole |
| Izithethantonye | CGS-20267;Femara |
| Inombolo yeCAS | 112809-51-5 |
| Inombolo yeCAT | RF-API86 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
| Ifomula yeemolekyuli | C17H11N5 |
| Ubunzima beMolekyuli | 285.3 |
| Indawo yokunyibilika | 181.0 ukuba 183.0℃ |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder |
| Ukunyibilika | Inyibilika ngokukhululekileyo kwiDichloromethane, iNyibilika kancinane kwi-Ethanol kwaye ayinyibiliki ngokufanelekileyo emanzini |
| Ukuchongwa kwe-IR | I-Spectrum yesampuli ihambelana naleyo yomgangatho wereferensi |
| Ukuchongwa kwe-HPLC | Ixesha lokugcinwa kwesampulu yovavanyo lihambelana nelo lomgangatho wereferensi |
| Isiqulatho samanzi (nge-KF) | ≤0.30% |
| Intsalela kwi-Ignition | ≤0.10% |
| Izinto ezinxulumeneyo | |
| Izinto ezinxulumeneyo A | ≤0.30% |
| Izinto ezinxulumeneyo B | ≤0.20% |
| Nakuphi na Ukungcola Okungachazwanga | ≤0.10% |
| Ukungcola okungachazwanga ngokupheleleyo | ≤0.30% |
| Ukungcola ngokupheleleyo | ≤0.50% |
| Izinyibilikisi ezishiyekileyo | |
| I-Ethyl Acetate | ≤0.50% |
| IMethanol | ≤0.30% |
| I-Ethanol | ≤0.50% |
| I-DMF | ≤0.088% |
| Iintsimbi ezinzima | ≤10ppm |
| Isivavanyi | 98.0% ~ 102.0% (kwisiseko se-anhydrous) |
| Beka ubomi kwishelufa | Iinyanga ezingama-24 |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | API, Aromatase Inhibitor II |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Letrozole (i-CAS 112809-51-5) yinxalenye yesizukulwana esitsha se-aromatase inhibitors ekhethiweyo kakhulu kwaye i-artificially synthesized benzotriazole derivative.I-Letrozole inqanda i-aromatase ekunciphiseni amanqanaba e-estrogen, ngaloo ndlela ikhusela i-estrogen ekukhuthazeni ukukhula kwe-tumor.Umsebenzi wayo we-vivo unamandla ngamaxesha angama-150-250 kunalowo wesizukulwana sokuqala i-aromatase inhibitor i-Amarante.Njengoko ikhetha kakhulu, ayiyi kuchaphazela i-glucocorticoid, i-mineralocorticoid kunye nemisebenzi ye-thyroid;nakwiidosi eziphezulu, aziyi kuba nemiphumo yokuthintela kwi-adrenal corticosteroid secretion, inika isalathisi esiphezulu sonyango.I-Letrozole ayinayo i-toxicity efihlakeleyo kuyo nayiphi na inkqubo yomzimba kunye nezitho ezijoliswe kuyo, ayinayo i-mutagenicity kunye nemiphumo ye-carcinogenic, ineempembelelo ezincinci ezinobuthi, inyamezeleke kakuhle, kwaye ineempembelelo ezinamandla ze-anticancer kunezinye i-aromatase inhibitors kunye neziyobisi ze-antiestrogen.I-Letrozole ifanelekile kwizigulane zomhlaza webele eziphucukileyo ze-postmenopausal ezingakhange ziphendule unyango lwe-estrogen-suppressing kunye nonyango lomhlaza webele kwangoko.Isetyenziselwa ukunyanga izigulane zasemva kokuyeka ukuya exesheni ezinomhlaza webele ophezulu kwaye isebenza njengonyango lodidi lwesibini ukulandela unyango lwe-antiestrogen olungaphumelelanga.
