Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 High Purity

Inkcazelo emfutshane:

Igama leMichiza: Lopinavir

CAS: 192725-17-0

Imbonakalo: Imhlophe ukuya kwiPowder eMhlophe

Uvavanyo (HPLC): 98.0% ~ 102.0%

I-Peptidomimetic HIV-1 Protease Inhibitor ekhethiweyo

Umgangatho ophezulu we-API, iMveliso yoRhwebo

Inquiry: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ubonelelo lwabavelisi ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leMichiza: Lopinavir
CAS: 192725-17-0
I-Peptidomimetic HIV-1 Protease Inhibitor enamandla kakhulu, eKhethekileyo
IMveliso yoPhando oluNxulumene ne-COVID-19
Umgangatho ophezulu we-API, iMveliso yoRhwebo

Iipropati zeMichiza:

Igama leMchiza	Lopinavir
Izithethantonye	I-LPV;ABT-378;Kaletra
Inombolo yeCAS	192725-17-0
Inombolo yeCAT	RF-API73
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram
Ifomula yeemolekyuli	C37H48N4O5
Ubunzima beMolekyuli	628.81
Ugcino Lwexesha elide	Gcina ixesha elide kwi-2-8 ℃
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kwi-Off-White Powder
Ukunyibilika	I-Soluble ngokukhululekileyo kwi-Methanol kunye ne-Ethanol, i-Soluble kwi-2-Propanol
Ukuchongwa kwe-IR	Uluhlu lokufunxa lwe-infrared lwesampulu yovavanyo luhambelana ne-spectrum yomgangatho wereferensi.
Ukuchongwa kwe-HPLC	Ixesha lokugcinwa kwesampulu yovavanyo lihambelana nelo lomgangatho wereferensi
Isiqulatho samanzi (nge-KF)	≤4.0%
Ujikelezo oluKhethekileyo lwe-Optical	-22.0 ° ukuya -26.0 °
Intsalela kwi-Ignition	≤0.20%
Iintsimbi ezinzima	≤20ppm
Indawo yokunyibilika	124.0 ukuba 127.0℃
Uthuthu lweSulfate	≤0.20%
Intsalela yokunyibilika (Ethanol)	≤0.50%
Izinto ezinxulumeneyo	(HPLC, Ummandla%)
Ukungcola 1
Ukungcola B (RRT=0.07)	≤0.20%
Ukungcola I (RRT=1.10)	≤0.20%
Nakuphi na Okunye Ukungcola	≤0.10%
Ukungacoceki 2	Nakuphi na okunye ukungcola komntu ≤0.10%
Ubumdaka bubonke obusuka kwiNkqubo yoku-1 neyesi-2	≤0.70%
Ukungcola ngokupheleleyo	≤1.0%
Uvavanyo (nge-HPLC)	98.0%~102.0%
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	I-Peptidomimetic HIV-1 Protease Inhibitor, iMveliso yoPhando eNxulumene ne-COVID-19

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

Izinto eziluncedo:

FAQ:

Isicelo:

I-Lopinavir (ABT-378) yi-peptidomimetic inhibitor enamandla kakhulu, ekhethiweyo ye-HIV-1 protease, ene-Kis ye-1.3 ukuya ku-3.6 pM yohlobo lwasendle kunye ne-HIV protease eguqukayo.I-Lopinavir isebenza ngokubamba ukukhula kwe-HIV-1 ngokuthintela ukosuleleka kwayo.I-Lopinavir ikwayi-SARS-CoV 3CLpro inhibitor ene-IC50 ye-14.2 μM.I-Lopinavir yi-antiretroviral yodidi lwe-protease inhibitor.Ukuvinjelwa kwe-HIV-1 protease kuthintela ukukrazuka kwe-polyprotein precursor yentsholongwane kwaye kubangele ukukhululwa kwe-virion engekavuthwa, engasuleliyo.Ilungu lonyango oludityanisiweyo lokunyanga i-HIV/AIDS.I-Lopinavir, i-HIV protease inhibitor yesithandathu kudidi lwe-“navir”, yasungulwa ngokuhambelana ne-ritonavir, enye i-HIV protease inhibitor esele ithengisiwe (Abbott, 1996);olu qulunqo lwaqalwa njengeKaletra ukuze lusetyenziswe ngokudityaniswa nokuba yi-nucleoside okanye i-non-nucleoside reverse transcriptase inhibitors kunyango lwe-AIDS kubantu abadala kunye nabantwana.I-Lopinavir yikhompawundi ye-peptidomimetic enesiseko esisisiseko esifana naleyo ye-ritonavir, apho amaqela e-terminal, ngakumbi i-valine elungisiweyo, yaziswa ngeenkqubo zokudibanisa i-peptide.I-Lopinavir sisithinteli esinamandla sokhuphiswano lwe-HIV-I protease ebonisa amandla aphezulu ngokuchasene notshintsho lwe-ritonavir-resistant.Kwiintlobo ezininzi zezilwanyana, izifundo ze-pharmacokinetic kunye nombutho we-lopinavirlritonavir zibonise ukuba iipropathi ezithobekileyo ze-lopinavir ziphuculwe kakhulu kubukho be-ritonavir, ngokwe-Cmax kunye nobude besenzo.