Methyl 2-Oxoindoline-6-Carboxylate CAS 14192-26-8 Ubunyulu >99.0% (HPLC) Nintedanib Esylate Intermediate Factory
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi weMethyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) enomgangatho ophezulu, imveliso yorhwebo.
Igama leMchiza | I-Methyl 2-Oxoindoline-6-Carboxylate |
Izithethantonye | I-2-Oxoindoline-6-Carboxylic Acid Methyl Ester;I-Methyl Oxindole-6-Carboxylate |
Inombolo yeCAS | 14192-26-8 |
Inombolo yeCAT | RF-PI1524 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C10H9NO3 |
Ubunzima beMolekyuli | 191.19 |
Indawo yokunyibilika | 184.0 ~ 190.0℃ |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umthubi oKhanyayo ukuya kumgubo oBrown |
I-1 H NMR Spectrum | Ukungqinelana Nolwakhiwo |
Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
Ilahleko ekomisweni | <1.00% |
Ukungcola ngokupheleleyo | <1.00% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Umbindi weNintedanib Esylate (CAS: 656247-18-6) |
I-Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) Indlela yokwenziwa
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-Methyl 2-Oxoindoline-6-Carboxylate (i-CAS: 14192-26-8) yindawo ephakathi esetyenziselwa ukulungiselela i-Nintedanib Esylate (CAS: 656247-18-6).I-Nintedanib Esylate inamandla, i-oral triple angiokinase inhibitor ephuhliswe nguBoehringer Ingelheim ejolise kwiindlela zeproangiogenic kunye ne-pro-fibrotic ezidityaniswe yi-vascular endothelial growth factor receptor, i-fibroblast growth factor receptor kunye ne-plateletderived growth factor receptor iintsapho, kunye ne-Src kunye ne-Flt-3 kinases.I-Nintedanib Esylate ivunyiwe kunyango lwe-idiopathic pulmonary fibrosis (IPF), imeko apho imiphunga iba namanxeba ngokuqhubekayo ngokuhamba kwexesha, yi-US FDA ngo-Okthobha ka-2014 kunye ne-EMA ngoJanuwari 2015. I-FDA inike i-nintedanib esylate ngokukhawuleza , uphononongo oluphambili, imveliso yeenkedama, kunye nokutyunjwa kwempumelelo.Ikwaphunyezwe yi-EMA ngoNovemba ka-2014 kunyango lomhlaza wemiphunga ongeyonxalenye encinci kunye ne-docetaxel emva kwechemotherapy yodidi lokuqala.
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