Methyl 4-(Bromomethyl)-3-Methoxybenzoate CAS 70264-94-7 Zafirlukast Intermediate
Ubonelelo lwabavelisi, ubunyulu obuphezulu, iMveliso yoRhwebo
Igama leKhemikhali: Methyl 4-(Bromomethyl) -3-Methoxybenzoate
CAS: 70264-94-7
Igama leMchiza | I-Methyl 4-(Bromomethyl) -3-Methoxybenzoate |
Izithethantonye | I-4-(Bromomethyl) -3-methoxybenzoic Acid Methyl Ester;I-Methyl 4-(Bromomethyl)-m-anisate;4-(Bromomethyl)-m-anisic Acid Methyl Ester |
Inombolo yeCAS | 70264-94-7 |
Inombolo yeCAT | RF-PI437 |
Ubume beStokhwe | Ikhona evenkileni |
Ifomula yeemolekyuli | C10H11BrO3 |
Ubunzima beMolekyuli | 259.10 |
Indawo yokunyibilika | 92.0 ukuba 94.0℃ |
Ukuxinana | 1.432 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMthubi oMthubi |
Indlela yoVavanyo / yoHlahlelo | ≥98.0% (HPLC) |
Ilahleko ekomisweni | ≤1.0% |
Intsalela kwi-Ignition | ≤0.50% |
Ukungcola ngokupheleleyo | ≤2.0% |
Iintsimbi ezinzima | ≤20ppm |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | I-Intermediate of Zafirlukast (CAS: 107753-78-6), Isetyenziswe njenge-antiasthmatic |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-Methyl 4-(Bromomethyl) -3-Methoxybenzoate (i-CAS 70264-94-7) isetyenziswe njengendawo ephakathi ye-Zafirlukast (CAS: 107753-78-6).I-Zafirlukast ikhetha kakhulu kwaye ithatha ixesha elide i-lys-LTs yomlomo ochasayo.I-Leukotrienes idlala indima ebalulekileyo kwi-pathogenesis ye-asthma.Ezi zinto zi-peptides, ezikwazi ukubopha ngokukhethayo kwi-LTC4, i-LTD4 kunye ne-LTE4 receptor ngokuchasa umphumo wayo, ukunciphisa iimpawu ze-asthma kunye nokuphucula ukusebenza kwemiphunga.Le mveliso zombini i-arhente yokuthintela ukudumba okubangelwa sisifuba (ukuchasana ne-leukotriene umsebenzi we-proinflammatory) kunye neyeza lokukhulula kwi-asthma ye-bronchial (yichase i-leukotriene eyenza ukunqanyulwa kwemisipha ye-bronchial egudileyo).Ukusetyenziswa kwale mveliso ayitshintshi impendulo ye-muscle egudileyo kwi-receptors ye-β2 kwaye inokusebenza kakuhle kunyango lwe-bronchoconstriction ebangelwa yi-antigen, i-aspirin, ukuzivocavoca kunye nomoya obandayo, ukukwazi ukunciphisa umthamo we-hormone kunye ne-β2 receptor agonist.
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