Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8 PF-07321332 Boceprevir Intermediate Featured Image

Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8 PF-07321332 Boceprevir Phakathi

Inkcazelo emfutshane:

Igama leMichiza: Methyl (S) -2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate

CAS: 328086-60-8

Imbonakalo: Mhlophe ukuya kwi-Off-White Powder

Phakathi kwe-PF-07321332 Paxlovid (CAS 2628280-40-8) kunye ne-Boceprevir (CAS 394730-60-0)

Umgangatho ophezulu, iMveliso yoRhwebo

Inquiry: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

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Inkcazo:

Ubonelelo ngezoRhwebo PF-07321332 Paxlovid abaPhakathi abaNxungupheleyo abanoMgangatho oPhezulu
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(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride 565456-77-1
I-Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8
6,6-Dimethyl-3-azabicyclo[3.1.0]hexane CAS 943516-54-9

Iipropati zeMichiza:

Igama leMchiza	IMethyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate
Izithethantonye	I-Methyl (S) -2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate;(αS,3S) -α-[(tert-Butyloxycarbonyl)aMino]-2-oxo-3-pyrrolidinepropanoic acid iMethyl Ester;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate
Inombolo yeCAS	328086-60-8
Inombolo yeCAT	RF-PI317
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram
Ifomula yeemolekyuli	I-C13H22N2O5
Ubunzima beMolekyuli	286.33
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kwi-Off-White Powder
Isazisi A	I-IR: Ifana neNgcaciso yeNgcaciso
Isazisi B	Ixesha lokuGcina: Liyafana neNxibelelwano yeSiza
Ilahleko ekomisweni	≤1.0%
Intsalela kwi-Ignition	≤0.20%
Ukungacoceki Okukodwa	≤0.50%
Ukungcola ngokupheleleyo	≤2.0%
Iintsimbi ezinzima (Pb)	≤20ppm
Ubunyulu	≥98.0%
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Phakathi kwe-PF-07321332 Paxlovid (CAS 2628280-40-8) kunye ne-Boceprevir (CAS 394730-60-0)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

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Isicelo:

I-Methyl (S)-2- (Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate (CAS 328086-60-8) yindawo ephakathi ye-PF-07321332 Paxlovid (CAS 2628280-40) -8) kunye ne-Boceprevir (CAS 394730-60-0).PF-07321332, icandelo eliphambili le-Paxlovid (PF-07321332 kunye ne-Ritonavir) engumgqatswa we-COVID-19 oral antiviral, yi-3C-like protease inhibitor efumanekayo ngomlomo (3CLPRO) eneziphumo ezinamandla zokulwa nentsholongwane ye-SARS-CoV-2 kunye ne-COVID-19.Ngomhla we-6 kaNove ngo-2021, uPfizer wabhengeza ukuba uPaxlovid unciphise kakhulu ukulaliswa esibhedlele kunye nokufa, ngokusekwe kuhlalutyo lwethutyana lweSigaba 2/3 se-EPIC-HR (Vavaluation of Protease Inhibition for COVID-19 in High-Risk Patients) uphando olungacwangciswanga, oluyimfama kabini. yabaguli abangalaliswanga esibhedlele abane-COVID-19, abasengozini enkulu yokuqhubekela phambili kwisigulo esiqatha.I-Boceprevir (EBP-520) yi-HCV protease inhibitor (Ki=14 nM) kunyango lwentsholongwane ye-hepatitis C.I-Boceprevir ene-pegylated interferon kunye ne-ribavirin (i-PegIFN / RBV) yenza ukuphuculwa kwemilinganiselo eqhubekayo ye-virological impendulo yezigulane ezine-genotype 1 HCV.I-Boceprevir isebenzisana ne-immunosuppressive therapy (IT) ngokuvimbela i-cytochrome P450 3A enzyme.