N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Ubunyulu > 99.0% (HPLC) I-Afatinib Dimaleate Intermediate Factory

Inkcazelo emfutshane:

Igama leMichiza: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Mthubi oKhanyayo ukuya kumgubo otyheli

Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-enye CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Iipropati zeMichiza:

Igama leMchiza	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Izithethantonye	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl) (7-Fluoro-6-Nitroquinazolin-4-yl) amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;Afatinib Intermediate A
Inombolo yeCAS	162012-67-1
Inombolo yeCAT	RF-PI2026
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C14H7ClF2N4O2
Ubunzima beMolekyuli	336.68
Uvakalelo	Ukungeva kuMoya, Ubushushu abuva
Indawo yokunyibilika	242.0~244.0℃
Indawo yokubilisa	489℃
Ukuxinana	1.616
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oMthubi oKhanyayo ukuya kumthubi
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)
Ilahleko ekomisweni	<0.50%
Intsalela kwi-Ignition	<0.20%
Izinto ezinxulumeneyo
Ukungacoceki komntu	<0.50%
Ukungcola ngokupheleleyo	<1.00%
Iintsimbi ezinzima	≤20ppm
I-Infrared Spectrum	Iyahambelana neSakhiwo
Proton NMR Spectrum	Iyahambelana neSakhiwo
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

I-N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (i-CAS: 162012-67-1) iphakathi kwi-synthesis ye-Afatinib Dimaleate (CAS: 850140-73-7) .I-Afatinib Dimaleate yindlela yetyuwa ye-Afatinib.I-Afatinib isizukulwana sesibini, esilawulwa ngomlomo, esingenakuguqulwa inhibitor ye-ErbB intsapho ye-tyrosine kinases.I-Mechanism of ActionAfatinib ilawula ukubonakaliswa kwe-ErbB ngokuzibophelela ngokubambisana kwi-kinase domains ye-epidermal growth factor receptor (EGFR), i-epidermal growth factor receptor (HER) i-2 kunye ne-HER4, okubangelwa ukuvinjelwa okungenakukwazi ukuguqulwa kwe-tyrosine kinase autophosphorylation;iphinda inqanda i-transphosphorylation ye-HER3.I-Afatinib ivunyiwe njenge-monotherapy yonyango lwe-EGFR tyrosine kinase inhibitor (TKI) -abantu abadala abangenayo indawo ephakamileyo okanye i-DefinitionChEBI: Ityuwa ye-maleate efunyenwe ngokudibanisa i-afatinib kunye ne-molar equivalents ezimbini ze-maleic acid.Isetyenziselwa unyango lodidi lokuqala lwezigulane ezinomhlaza wemiphunga we-metastatic ongeyonxalenye encinci.