N-Hydroxysuccinimide (HOSu) CAS 6066-82-6 Coupling Reagent Purity >99.0% (HPLC)

Inkcazelo emfutshane:

Igama leMichiza: N-Hydroxysuccinimide

Izithethantonye: HOSu;I-NHS

CAS: 6066-82-6

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Umgubo weCrystalline oMhlophe

Ukudibanisa i-Reagent ye-Peptide, uMgangatho oPhezulu

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-N-Hydroxysuccinimide (HOSu) (i-CAS: 6066-82-6) enomgangatho ophezulu.I-Ruifu Chemical ibonelela ngothotho lwee-reagents ezikhuselayo kunye ne-coupling reagents.I-Ruifu inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, amanani amancinci kunye nesixa esikhulu esikhoyo.Thenga i-N-Hydroxysuccinimide,Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	N-Hydroxysuccinimide
Izithethantonye	HOSu;NHS;1-Hydroxysuccinimide;I-1-Hydroxy-2,5-Pyrrolidinedione;I-N-Hydroxy-2,5-dioxopyrrolidine
Ubume beStokhwe	Kwi-Stock, iMveliso yeMisa
Inombolo yeCAS	6066-82-6
Ifomula yeemolekyuli	C4H5NO3
Ubunzima beMolekyuli	115.09 g/mol
Indawo yokunyibilika	93.0~98.0℃(lit.)
Ukuxinana	1.649
Inovakalelo	Hygroscopic.Ubushushu Bunobuzaza, Bunobuntununtunu
Ukunyibilika kwiDioxane	Inyibilika kwiDioxane, Phantse Ukungafihli
Ukunyibilika emanzini	Inyibilika emanzini
Ugcino Temp.	Indawo epholileyo neyomileyo (2~8℃)
I-COA kunye ne-MSDS	Iyafumaneka
Udidi	Coupling Reagents
Uphawu	Ruifu Chemical

Iinkcukacha:

Izinto	ImiGangatho yokuHlola	Iziphumo
Imbonakalo	Umgubo weCrystalline oMhlophe	Iyahambelana
Indawo yokunyibilika	93.0~98.0℃	94.0 ~ 97.0℃
Ilahleko ekomisweni	<0.50%	0.15%
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)	99.5%
I-Infrared Spectrum	Iyahambelana neSakhiwo	Iyahambelana
Proton NMR Spectrum	Iyahambelana neSakhiwo	Iyahambelana
Ukuqukumbela	Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha

Indlela yoVavanyo:

Isigaba seselula: 0.1% isisombululo se-phosphoric acid: acetonitrile = 90:10
Ubude bobude: 220nm
Izinga lokuhamba: 1ml / min

Ukupakishwa/uGcino/Ukuhambisa ngenqanawe:

Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Ukuqonda ukufuma.Gcina kwizikhongozeli ezivaliweyo kwindawo yokugcina impahla epholileyo neyomileyo (2~8℃) kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.

Izinto eziluncedo:

Umthamo owaneleyo: Izixhobo ezaneleyo kunye namagcisa

Inkonzo yobuNgcali: Inkonzo enye yokuyeka ukuthenga

Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

Inkonzo yesiNtu yoHlanganiso: Isuka kwiigram ukuya kwiikhilos

Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.

Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.

Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.

UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.

Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.

Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.

MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.

Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.

Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.

Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.

Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.

Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.

6066-82-6 - Umngcipheko kunye noKhuseleko:

Iimpawu zeHazard Xi - Irritant
Iikhowudi zoMngcipheko
36/37/38 - Ukucaphukisa emehlweni, inkqubo yokuphefumula kunye nesikhumba.
Inkcazelo yoKhuseleko
S22 - Musa ukuphefumla uthuli.
I-S24/25 - Gwema ukudibana nolusu kunye namehlo.
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S36 - Nxiba iimpahla ezifanelekileyo zokukhusela.
WGK eJamani 3
TSCA Ewe
Ikhowudi yeHS 2925190090
I-Hazard Note irritant

Isicelo:

I-N-Hydroxysuccinimide (HOSu) (i-CAS: 6066-82-6), i-reagent yokulungiselela i-esters esebenzayo ye-amino acids.I-ejenti yokudibanisa i-peptide yesigaba esiqinileyo.
I-N-Hydroxysuccinimide isoloko isetyenziselwa ukuncedisa ukudityaniswa kwe-peptide ye-carbodiimide-mediated ngokwenza i-ester ephakathi esebenzayo ngokuxinana kweqela le-carboxyl elingaphezulu kunye ne-NHS.I-NHS-reactive ester intermediate ichaphazeleka ekuhlaselweni kwe-nucleophilic ngama-amine aphambili kwaye iphumela ekubunjweni kweebhondi ze-amide ezizinzile phakathi kwendawo ye-biomaterial kunye ne-N-terminus ye-peptide.
I-N-Hydroxysuccinimide i-succinimide ye-hydroxylated esetyenziswa ngokubanzi ekusebenziseni i-carboxylic acids kwi-NHS-esters ukukhuthaza ukudibanisa kunye ne-nucleophiles.Le ndlela isetyenziswa ngokuqhelekileyo ekusebenziseni iifom ze-asidi zamahhala ze-fluorophores zokukhuthaza ukudibanisa kwezi fluorophores kwiintsalela ze-amine zeeprotheni.Ukusetyenziswa kwe-NHS ester activation nayo ichazwe kwi-synthesis ye-N-acyl amino acids.
Isetyenziselwa ukuhlanganiswa kwe-amino acid ekhuselayo, i-semi-synthetic kanamycin kunye ne-pharmaceutical intermediates.I-N-hydroxybutyldiimide kunye nezinto eziphuma kuyo zizinto ezibalulekileyo zokwenziwa kwe-peptides, i-antibiotics, i-amino acids kunye neeprotheni.I-N-hydroxybutyldiimide isetyenziselwa ukulungiswa kwezinto ezisebenzayo. i-esters, kunye nokuvinjelwa kwempembelelo ye-optically esebenzayo yokudibanisa i-peptide inoluhlu olubanzi lwe-USES kumayeza, kwaye iyimathiriyeli esisiseko yeekhemikhali.
I-N-Hydroxysuccinimide isetyenziselwa ukuphuculwa kwe-amidations kwindlela ye-carbodiimide.Ikwasetyenziselwa ukwenza iqela le-carboxyl lisebenze kwaye lidibana ne-amine ukwenza i-amide.Ibandakanyeka ekulungiseleleni i-N-hydroxymaleimide-styrene copolymer.

Indlela yokuvelisa:

I-N-Hydroxysuccinimide yalungiswa ngolu hlobo lulandelayo: I-100g (1.0mol) i-anhydride ye-succinic kunye ne-70g (1.0mol) ye-hydroxylamine hydrochloride ifudunyezwa kunye, inkqubo yokusabela igcinwa phantsi koxinzelelo olubi lokususa ii-volatiles ezenziweyo, kwaye ishushu ngokukhawuleza ukuya ngaphezu kwe-125 ℃ , kwaye ngokucothayo inyuke iye kwi-160℃ emva kwe-1H.Ukufudumeza kuyekwa kwaye xa ubushushu behla ukuya kwi-125 ℃, ukusabela kolwelo kwagalelwa kwi-diethyl ether kwaye yavuselelwa ngamandla.Emva kokuba imveliso iphilisiwe, i-ether layer yahluthwa, imveliso enyangisiweyo yafudumeza ukubilisa nge-400ml ye-butanol, ishushu yahluzwa, kwaye ifiltrate yapholiswa ngokukhawuleza ukuya kwi-0℃.Emva kokuhluzwa kwe-1H, iikristali zahlanjwa ngokulandelelana nge-butanol kunye ne-diethyl ether, kwaye imveliso ekrwada efunyenweyo yaphinda yahlaziywa kwi-ethyl acetate ukufumana i-50g yemveliso egqityiweyo kwi-44% yesivuno.