N (4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC Umgangatho ophezulu
Ukubonelela ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leMichiza: N (4)-Hydroxycytidine;I-EIDD-1931 (NHC)
CAS: 3258-02-4
Imetabolite esebenzayo ye-Molnupiravir, i-COVID-19 inhibitor ethembisayo
| Igama leMchiza | N (4)-Hydroxycytidine |
| Izithethantonye | I-EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| Inombolo yeCAS | 3258-02-4 |
| Inombolo yeCAT | RF-PI309 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kwiiKilogram |
| Ifomula yeemolekyuli | I-C9H13N3O6 |
| Ubunzima beMolekyuli | 259.22 |
| Indawo yokunyibilika | 169.0 ~ 172.0℃ |
| Ukunyibilika | Inyibilika ukuya kwi-100 mM kwi-DMSO nakwi-50 mM emanzini |
| Ukuxinana | 1.93±0.1 g/cm3 |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mhlophe ukuya kwi-Off-White Powder |
| NMR | Ngokungqinelana noLwakhiwo |
| Ubunyulu / Indlela yokuHlalutya | >98% (HPLC) |
| Ilahleko ekomisweni | ≤1.0% |
| Ukungacoceki Okukodwa | ≤0.50% |
| Iintsimbi ezinzima | ≤20ppm |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Imetabolite esebenzayo ye-Molnupiravir (EIDD-2801), i-COVID-19 inhibitor |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-N (4)-Hydroxycytidine (EIDD-1931, β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) yi-metabolite esebenzayo ye-EIDD-2801, i-COVID-19 inhibitor ethembisayo.I-EIDD-1931 (NHC) inomsebenzi obanzi we-antiviral ngokuchasene ne-coronavirus ezininzi, kubandakanya i-SARS-CoV-2, i-MERS-CoV, i-SARS-CoV, kunye neqela elinxulumene ne-zoonotic 2b okanye i-2c Bat-CoVs kunye ne-IC50 eqhelekileyo ye-0.15 μM, kunye ukonyuka kwamandla ngokuchasene ne-coronavirus ethwele ukuchasana kweenguqu kwi-nucleoside analog inhibitor remdesivir.Kwiimpuku ezosulelwe yi-SARS-CoV okanye i-MERS-CoV, zombini i-prophylactic kunye nolawulo lonyango lwe-Molnupiravir (EIDD-2801), i-NHC-prodrug ye-bioavailable ngomlomo (β-D-N4-hydroxycytidine-5'-isopropyl ester), ukuphuculwa komsebenzi we-pulmonary , kunye nokunciphisa i-virus titer kunye nokunciphisa umzimba.Ukuncipha kwemveliso ye-MERS-CoV kwi-vitro kunye ne-vivo yayanyaniswa nokunyuka kwenguqu yokuguquka rhoqo kwintsholongwane kodwa ingeyiyo iseli ye-RNA, exhasa indlela yokubulala i-mutagenesis kwi-CoV.Amandla e-NHC/EIDD-2801 ngokuchasene neekoronavirus ezininzi kunye nokufumaneka komlomo ngomlomo kuqaqambisa usetyenziso olunokubakho njenge-antiviral esebenzayo ngokuchasene ne-SARS-CoV-2 kunye nezinye ii-zoonotic coronaviruses zexesha elizayo.
