I-Octreotide Acetate CAS 83150-76-9 Peptide Purity (HPLC) ≥98.0% API Umgangatho ophezulu

I-Octreotide Acetate (i-Sandostatin) yi-analogue ye-peptide yokwenziwa ye-hormone somatostatin, i-analogue ye-somatostatin yexesha elide eboniswa ukulawula iimpawu kwi-acromegaly kunye ne-gastroenteropancreatic tumors.Ezinye izinto ezinokuthi zisetyenziswe phantsi kophando ziquka isifo seswekile, i-psoriasis kunye nesifo se-Alzheimer's.I-Octreotide Acetate (i-Sandostatin) yi-analogue ye-peptide yokwenziwa ye-hormone somatostatin.Izenzo zayo ziquka ukuvinjelwa kwe-pituitary secretion ye-hormone yokukhula kunye nokuvinjelwa kwe-pancreatic islet cell secretion ye-insulin kunye neglucagon.Ngokungafani ne-somatostatin, ene-plasma-half-life yemizuzu embalwa, i-Octreotide ine-plasma yokuphelisa i-half-life ye-1 kwiiyure ze-2.Ukukhutshelwa kwechiza ikakhulu kwizintso.I-Octreotide inciphisa ukuhamba kwesisu kwaye inqanda ukucutheka kwe-gall bladder.

Iziyobisi ze-Peptide i-Novartis Sandostatin (i-Octreotide Acetate), i-synthetic yendalo ye-somatostatin octapeptide derivatives, igcina i-pharmacological effect efana ne-somatostatin, kwaye umphumo uhlala ixesha elide.Iimpawu ze-Octreotide Acetate ziquka i-acromegaly;Ukunciphisa iimpawu kunye neempawu ezinxulumene ne-gastroenteropancreatic endocrine neoplasia esebenzayo;Kwaye ukusebenza kakuhle kwiCarcinoid Tumors ebonisa i-carcinoid syndrome, i-VIP tumors, kunye ne-glucagon tumors.Ukongeza, i-Octreotide Acetate ye-gastrinomas / Zollinger-Ellison syndrome (ehlala idityaniswa neproton pump inhibitors okanye i-H2 receptor blockers), i-Insulinomas (uthintelo lwangaphambili lwe-hypoglycemia kunye nokugcinwa kweswekile yegazi eqhelekileyo), isantya esisebenzayo sokukhula kwehomoni ekhupha ithumba. malunga nama-50%.

I-Octreotide Acetate yi-inshurensi yezempilo yesizwe ye-Inshurensi ye-B, eyimveliso ye-octapeptide yendalo yokwenziwa kwe-somatostatin, xa kuthelekiswa ne-somatostatin yendalo, i-half-life ye-somatostatin ngokucacileyo yande kwaye ineempembelelo ezifanayo ze-pharmacological, kubandakanywa ukuvinjelwa komsebenzi we-hormone yokukhula, inhibition. ye-asidi ye-gastric, i-pancreatic enzyme, i-glucagon kunye ne-insulin secretion, kunye nokunciphisa ukuhamba kwegazi kwe-visceral, ukunciphisa ukuhamba kwesisu.Xa kuthelekiswa ne-somatostatin yendalo, i-octreotide inobomi obude besiqingatha sobomi, ikhethe ngakumbi ukuthintela ukukhuselwa kwehomoni yokukhula kunokuthintela ukukhuselwa kwe-insulin, kwaye ayibangeli i-rebound hypersecretion yehomoni.I-1, utyando oluLawulayo okanye unyango lwe-radiation alukwazi ukulawula ngokwaneleyo isifo kwizigulane ezineempawu ze-acromegaly kunye nokunciphisa i-hormone yokukhula yesigulane (GH) i-insulin-efana nokukhula kwe-insulin -1 (1GF-1) amanqanaba eplasma.I-Sandostatin ingasetyenziselwa ukunyanga izigulane ezine-acromegaly ezingakwaziyo okanye ezingafuni ukwenza utyando, okanye ukunyanga izigulane ezine-acromegaly ezingekafumani unyango lwe-radiation.2. Ukunciphisa iimpawu ezinxulumene ne-functional gastroenteropancreatic (GEP) i-endocrine tumors ezifana ne-carcinoid tumors kunye ne-carcinoid syndrome ukubonakaliswa.ISandostatin ayilochiza elichasayo umhlaza kwaye ayinyangi ezi zigulana.I-3, Ukuthintelwa kweengxaki emva kokuhlinzwa kwe-pancreatic.I-4, izigulane ze-cirrhosis zesibindi ezine-gastric-esophageal variceal ukopha okubangelwa unyango oluphuthumayo, i-hemostasis kunye nokuthintela ukuphindaphinda, i-Sandostatin kufuneka idibaniswe ne-endoscopic sclerotherapy kunye nolunye unyango olukhethekileyo.