I-Olopatadine Hydrochloride ePhakathi CAS 27710-82-3 Ubunyulu > 99.0% (HPLC)
Umthengisi oPhambili we-Olopatadine Hydrochloride Intermediates
I-Olopatadine Hydrochloride CAS 140462-76-6
I-Isoxepac CAS 55453-87-7
[3-(Dimethylamino) propyl]triphenylphosphonium Bromide Hydrobromide CAS 27710-82-3
Please Contact: alvin@ruifuchem.com
| Igama leMchiza | [3-(Dimethylamino) propyl] triphenylphosphonium Bromide Hydrobromide |
| Izithethantonye | (3-Dimethylaminopropyl) triphenylphosphonium Bromide HBr |
| Inombolo yeCAS | 27710-82-3 |
| Inombolo yeCAT | RF2698 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | I-C23H28Br2NP |
| Ubunzima beMolekyuli | 509.27 |
| Indawo yokunyibilika | 283.0~285.0℃ |
| Uzinzo | Hygroscopic |
| Ukunyibilika | I-Chloroform (Kancinci), iMethanol (Kancinci) |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mhlophe ukuya kuMhlophe wePowder yeCrystal |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
| Indlela yoVavanyo / yoHlahlelo | >99.0% (Titration) |
| Ilahleko ekomisweni | <0.50% |
| Ukungacoceki Okukodwa | <0.50% |
| Ukungcola ngokupheleleyo | <1.00% |
| I-1 H NMR Spectrum | Ukungqinelana Nolwakhiwo |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Phakathi kwe-Olopatadine Hydrochloride (CAS: 140462-76-6) |
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[3-(Dimethylamino) propyl] triphenylphosphonium Bromide Hydrobromide (CAS: 27710-82-3) iphakathi kwe-Olopatadine Hydrochloride (CAS: 140462-76-6).I-Olopatadine Hydrochloride liyeza elichasayo.Ineempembelelo ezimbini zokuthintela ukukhutshwa kwe-histamine kunye nokuzikhethela ngokuchasayo i-receptors ye-HI, kwaye ayinayo inhibition ye-nervous system kunye ne-cardiac toxic side effects eziqhelekileyo kunye ne-HI receptor antagonist antiallergic drugs.I-Olopatadine Hydrochloride ayinakunqanda kuphela ukukhutshwa kwe-histamine kwiiseli ze-mast, kodwa iphinda ichase i-H1 receptors ngokukhetha ngakumbi, kwaye ayinayo impembelelo kwi-α adrenergic receptors, i-dopamine receptors, kunye ne-M1 kunye ne-M2 receptors.Phakathi kwabo, imiphumo yecala le-nervous system imbalwa, isizukulwana esitsha seziyobisi ezichasene ne-antiallergic ezikhethiweyo.I-Olopatadine inamandla, i-antagonist ekhethiweyo ye-H1 histamine receptor (Ki = 16-41.1 nM), ene-affinities ephantsi kakhulu kwi-H2 kunye ne-H3 receptors (Ki = 43.4 kunye ne-172 μM, ngokulandelanayo).Ivimbela ukuguqulwa kwe-histamine-induced phosphoinositide kwiiseli ezizimeleyo (IC50 = 9.5-39.9 nM) kwaye ikhusela i-anaphylaxis ye-cutaneous engabonakaliyo kwiigundane (ED50 = 49 μg / kg) kunye ne-anaphylactic bronchoconstriction kwi-guinea pigs (ID50 = 30 μg / kg).I-Olopatadine iyasebenza ekunyangeni i-rhinitis ye-allergen kunye ne-conjunctivitis.Ikwacinezela i-itch kwizigulane ezine-urticaria engapheliyo elawulwa kakuhle.Ebantwini, le antihistamine ayibangeli ukuphazamiseka kwengqondo okanye kwengqondo kwiidosi zonyango.
