Palonosetron Hydrochloride CAS 135729-62-3 Ubunyulu > 99.0% (HPLC) (T) API Factory

Inkcazelo emfutshane:

Igama leKhemikhali: Palonosetron Hydrochloride

CAS: 135729-62-3

Imbonakalo: Umgubo weCrystalline oMhlophe okanye oMhlophe

Ubunyulu: >99.0% (HPLC) (T)

I-Palonosetron Hydrochloride yinto enamandla kakhulu, ekhethiweyo kwaye esebenzayo ngomlomo i-5-HT3 i-receptor antagonist esetyenziselwa ukuthintela kunye nokunyangwa kwe-chemotherapy-induced nausea kunye nokuhlanza (CINV).I-Antiemetic.

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

Inquiry: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ubonelelo ngezoRhwebo iPalonosetron Hydrochloride kunye nabaPhakathi abaNxulumeneyo:
(S) -1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
I-3-Quinuclidinone Hydrochloride CAS: 1193-65-3
I-1-Naphthoic Acid CAS: 86-55-5
I-Palonosetron Hydrochloride CAS: 135729-62-3 API

Iipropati zeMichiza:

Igama leMchiza	I-Palonosetron Hydrochloride
Izithethantonye	IPalonosetron HCl;(S,S)-Palonosetron Hydrochloride;RS-25259;RS25259 197;(S)-2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-Hexahydro-1H-Benzo[de]isoquinolin-1-one Hydrochloride;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-Hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride ;IAloxi;I-Onicit
Inombolo yeCAS	135729-62-3
Inombolo yeCAT	RF-API03
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C19H24N2O·HCl
Ubunzima beMolekyuli	332.87
Umqathango Omele Uphetshwe	Ubushushu Bubuthathaka
Indawo yokunyibilika	307℃ (ngoDisemba)
Ukunyibilika emanzini	Inyibilika ngokupheleleyo emanzini
Ukunyibilika	Kancinci kakhulu ukunyibilika kwi-Ethanol
Ubushushu bokuthutha	Ubushushu obugciniwe
I-COA kunye ne-MSDS	Iyafumaneka
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo weCrystalline oMhlophe okanye oMhlophe
I-Palonosetron Hydrochloride	>99.0% (HPLC) (T)
Ukujikeleziswa okuthe ngqo [α]20/D	-98.0°～-104.0°
Ukuchongwa	Yongeza i-BiI7K4, Yenza i-Orenji ye-Orenji etyheli
Ukuchongwa	I-TLC Iyangqinelana neNgcaciso yeNgcaciso
Ukuchongwa	I-IR Iyangqinelana ne-IR esemgangathweni
Ukuchongwa	Ukuchongwa njengeChloride
Ukunyibilika	Inyibilika ngokukhululekileyo emanzini, inyibilika kancinane kwiMethanol, inyibilika kancinane kakhulu kwi-ethanol, ayinyibiliki kwi-acetone.
Ukucaca kunye nombala wesisombululo	Max.Yellow No. 2 Standard Color Solution
pH Vaule	4.5~6.5 (10mg/ml)
Izinto Eziyeleleneyo
iCompound A eyeleleneyo (NO)	<0.10%
iCompound B eNxulumeneyo (Ene-NO)	<0.10%
iCompound C enxulumeneyo (S,R)	<0.10%
iCompound D enxulumeneyo (R,S)	<0.50%
I-Palonosetron Enantiomer	<0.10%
iCompound E eyeleleneyo (3-Ene)	<0.50%
Ukungcola Okungachazwanga Okungatshatanga	<0.10%
Izinyibilikisi ezishiyekileyo
I-Ethanol	<3000ppm
Tetrahydrofuran	<5000ppm
I-DMF	<880ppm
IHexane eqhelekileyo	<290ppm
Utywala beMethyl	<3000ppm
Isopropanol	<5000ppm
I-methylbenzene	<890ppm
Amanzi	<0.30%
Intsalela kwi-Ignition	<0.20%
Ilahleko ekomisweni	<1.00%
Iintsimbi ezinzima	<10ppm
Umgangatho woVavanyo	I-United States Pharmacopoeia (USP);I-European Pharmacopoeia (EP)
Ukusetyenziswa	Palonosetron Hydrochloride API;5-HT3 Umchasi;I-CINV

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, Igubu lekhadibhodi, 25kg / Igubu, okanye ngokwemfuno yomthengi.

Ugcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

Izinto eziluncedo:

FAQ:

Isicelo:

I-Palonosetron Hydrochloride (i-CAS: 135729-62-3) iyeza lokuthintela isicaphucaphu kunye nokuhlanza, luhlobo olutsha olukhethiweyo oluphezulu, oluhambelana ne-5-HT3 i-receptor antagonist enokuthintela ukugabha iziko le-reflex peripheral neurons presynaptic 5-HT.I-receptor excitement ichaphazela ngokuthe ngqo inkqubo ye-nervous central kwi-5-HT.I-impulse receptor excitement eyenziwa yindima ye-vagal afferent nerve emva kommandla, ukuvimbela i-vagus nerve endings emathunjini, ukukhusela iimpawu kwi-5-HT.Indawo ye-receptor trigger zone inokunciphisa izehlo zesicaphucaphu kunye nokuhlanza.Embindini weklinikhi kunyango lwe-emetogenic ebukhali kakhulu ichemotherapy ebangela ukulibaziseka kwesicaphucaphu kunye nokugabha.Ngenxa yempembelelo yayo ephezulu yokunyanga, isiphumo esincinci, isiqingatha sobomi obude (malunga ne-40 h), idosi encinci, njalo njalo, iye yatsala ingqalelo enkulu.

Nge-1,2,3,4-Tetrahydro-1-Naphthoic Acid njengento yokuqala, ukuhlukana, ukuchithwa, ukunciphisa, i-cyclization, ityuwa ye-palonosetron hydrochloride granisetron.Izifundo zeklinikhi zibonise ukuba i-palonosetron ingasetyenziswa ngokukhuselekileyo kunye ne-corticosteroids, i-analgesics, i-antiemetics, i-antispasmodics kunye ne-anticholinergic drug njengezinto zokuqala, ukwahlukana, ukuchithwa, ukunciphisa, i-cyclization, ityuwa ye-palonosetron hydrochloride granisetron.