I-Paroxetine Hydrochloride Hemihydrate CAS 110429-35-1 Assay 97.5 ~ 102.0% Factory
Ubonelelo lweMichiza yeRuifu ngokucoceka okuphezulu
I-Paroxetine Hydrochloride Hemihydrate CAS 110429-35-1
N-Methyl Paroxetine CAS 110429-36-2
| Igama leMchiza | Paroxetine Hydrochloride Hemihydrate |
| Izithethantonye | (3S,4R)-(-)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride Hemihydrate;Paxil;iSeroxat;BRL29060 Hydrochloride Hemihydrate;BRL29060A Hemihydrate;I-Paroxetine-D4 HCl |
| Inombolo yeCAS | 110429-35-1 |
| Inombolo yeCAT | RF-PI1946 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C19H20FNO3·HCl·1/2H2O |
| Ubunzima beMolekyuli | 374.84 |
| Indawo yokunyibilika | 140.0 ~ 143.0℃ |
| Ukujikeleziswa okuthe ngqo [α]20/D | -88.0 ° ukuya -92.0 ° (C=1, MeOH, Calcd.on anh.substance) |
| Ukunyibilika | Ayinyibiliki ngokupheleleyo emanzini;I-Soluble kakhulu kwi-Dimethylformamide, i-Methanol;Inyibilika kwi-Ethanol |
| Uphawu | Ruifu Chemical |
| Imixholo | Iinkcukacha | Iziphumo |
| Imbonakalo | Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe | Vumelana |
| Isazisi A | I-infrared absorption spectrum kufuneka ihambelane ne-reference spectrum | Vumelana |
| Isazisi B | Indawo ephakamileyo kunye nexesha lokugcinwa kwesisombululo sovavanyo kufuneka lihambelane nesisombululo sokubhekisela | Vumelana |
| Isazisi C | Amanzi (nge-KF) | Vumelana |
| Isazisi D | Ukusabela kwiikloridi | Vumelana |
| Ukungcola D | ≤0.20% | Ukungabikho |
| Ukungcola G | ≤0.001% | |
| Izinto ezinxulumeneyo | Ukungcola A: ≤0.30% | 0.03% |
| Ukungcola okungachazwanga: Kukungcola ngakunye, ≤0.10% | 0.06% | |
| Ukungcola ngokupheleleyo: ≤0.50% | 0.10% | |
| Iintsimbi ezinzima | ≤0.002% | <0.002% |
| Amanzi (nge-KF) | 2.20%~2.70% | 2.46% |
| Uthuthu lweSulfated | ≤0.10% | <0.10% |
| Isivavanyi | 97.5% ~ 102.0% (Isixhobo esingenamanzi) | 100.2% |
| Izinyibilikisi ezishiyekileyo | ||
| IMethanol | ≤0.30% | 0.001% |
| I-acetone | ≤0.50% | 0.001% |
| Isopropanol | ≤0.50% | 0.04% |
| Dichloromethane | ≤0.06% | Akukho nanye |
| Toluene | ≤0.089% | 0.003% |
| Isiphelo: Ukuhambelana ne-EP7.0. | ||
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
I-Paroxetine Hydrochloride Hemihydrate (i-CAS: 110429-35-1) yenye yezona zinto zinamandla kwaye zikhetha i-serotonin reuptake inhibitors (SSRI);antidepressant.I-phenylpiperidine derivative, i-ST enamandla kakhulu kwaye ikhethiweyo (i-serotonin transporter / 5-HT) i-inhibitor yokunyuka.Isebenza ngokubophelela kwi-ST (i-serotonin transporter / SERT) kunye nobudlelwane obuphezulu (Ki = 05 nM).I-Antidepressant kunye ne-anxiolytic kwi-vivo.IParoxetine hydrochloride ingasetyenziselwa ukunyanga ukudakumba, elichiza elitsha lokuthomalalisa uxinzelelo.Isenokusetyenziswa ukunyanga uloyiko oluphangaleleyo, ukuphazamiseka kokuxhalaba ngokubanzi, ukuphazamiseka kokuxhalaba kwezentlalo, ukuphazamiseka okunyanzelekileyo (OCD), ukuphuthelwa, i-premenstrual syndrome, ukuphuma kwangaphambi kwexesha kunye nezinye izifo, ezinesiphumo esilungileyo sokunyanga kunye nokusabela okungathandekiyo.Nyanga zonke iintlobo zokudakumba.Kubandakanya ukudakumba kunye nexhala kunye nokudakumba okusebenzayo.Iimpawu eziqhelekileyo zokudandatheka: ukukhathala, ukuphazamiseka kokulala, ukungabi namdla kunye nokuzonwabisa kwimisebenzi yemihla ngemihla, ukulahlekelwa ngumdla.Emva kokuba isiphumo sonyango sanelisiwe, sinokuthintela ukuphindaphinda kokudakumba.
