Pazopanib Hydrochloride CAS 635702-64-6 Ubunyulu > 99.0% (HPLC) API Factory
Ubonelelo lwabavelisi ngoBusulungekileyo obuPhezulu kunye noMgangatho oZinzileyo
Igama leKhemikhali: Pazopanib Hydrochloride
CAS: 635702-64-6
I-Tyrosine kinase receptor inhibitor yonyango oluphezulu lwe-renal cell carcinoma okanye i-soft tissue sarcoma efumene i-chemotherapy yangaphambili.
Umgangatho ophezulu we-API, iMveliso yoRhwebo
Igama leMchiza | I-Pazopanib Hydrochloride |
Izithethantonye | I-Pazopanib HCl;GW786034 HCl;I-Votrient;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Hydrochloride |
Inombolo yeCAS | 635702-64-6 |
Inombolo yeCAT | RF-API93 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
Ifomula yeemolekyuli | I-C21H23N7O2S.ClH |
Ubunzima beMolekyuli | 473.987 |
Ukunyibilika | I-DMSO |
Indawo yokunyibilika | 300.0 ~ 304.0℃ |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMhlophe ukuya kumthubi kancinane |
Ukuchongwa | I-spectrum yokufunxa ye-infraed yesampulu yovavanyo ihambelana naleyo yomgangatho |
Intsalela kwi-Ignition | ≤0.50% |
Nakuphi na Ukungacoceki komntu | ≤0.30% |
Ukungcola ngokupheleleyo | ≤1.50% |
Iintsimbi ezinzima | ≤10ppm |
Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | I-API, iTyrosine kinase receptor inhibitor |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
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I-Pazopanib Hydrochloride (CAS 635702-64-6) i-multi-tyrosine kinase inhibitor ye-vascular endothelial growth factor receptor (VEGFR) -1, VEGFR-2, VEGFR-3, iplatelet-derived growth factor receptor (PDGFR) -α kunye - I-β, i-fibroblast factor receptor (FGFR) -1 kunye -3, i-cytokine receptor (Kit), i-interleukin-2 i-receptor-inducible T-cell kinase (Itk), iprotheni ye-lymphocyte-specific tyrosine kinase (Lck), kunye ne-transmembrane glycoprotein receptor tyrosine kinase (cFms).I-In vitro, pazopanib inhibited ligand-induced autophosphorylation ye-VEGFR-2, Kit, kunye ne-PDGFR-beta receptors.Kwi-vivo, pazopanib inhibited VEGF-induced VEGFR-2 phosphorylation in mouse lungs, angiogenesis kwimodeli yempuku, kunye nokukhula kwezinye i-tumor xenografts yabantu kwiimpuku.Yavunywa i-renal cell carcinoma yi-US Food and Drug Administration ngo-2009 kwaye ithengiswa phantsi kwegama lorhwebo iVotrient ngumenzi wechiza, i-GlaxoSmithKline.I-Votrient yi-kinase inhibitor eboniswe kunyango lwezigulane ezine: 1) i-renal cell carcinoma ephezulu.2) i-sarcoma yezicubu ezithambileyo eziye zafumana ichemotherapy yangaphambili.
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