Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate CAS 184177-81-9 Posaconazole Umgangatho oPhakamileyo oPhakathi
Ubonelelo lwefektri enobunyulu obuphezulu kunye nomgangatho ozinzileyo
I-Posaconazole eNxulumene neMveliso yoRhwebo
I-Posaconazole CAS 171228-49-2
I-Posaconazole ePhakathi POA CAS 149809-43-8
Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate CAS 184177-81-9
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine CAS 74853-08-0
2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal CAS 170985-85-0
I-Diethyl L-(+)-Tartrate CAS 87-91-2
Igama leMchiza | Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate |
Izithethantonye | I-Posaconazole ePhakathi |
Inombolo yeCAS | 184177-81-9 |
Inombolo yeCAT | RF-PI290 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C23H23N3O3 |
Ubunzima beMolekyuli | 389.45 |
Ukuxinana | 1.296 |
Imeko yokuthumela ngenqanawa | Phantsi koBubushushu be-Ambient |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umdaka omdaka ukuya kumgubo oMvu |
Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
Ilahleko ekomisweni | ≤0.50% |
Intsalela kwi-Ignition | ≤0.20% |
Iintsimbi ezinzima | ≤20ppm |
Ukungacoceki Okukodwa | ≤0.50% |
Ukungcola ngokupheleleyo | ≤1.0% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Umbindi wePosaconazole (CAS 171228-49-2) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Phenyl (4- (4- (4-hydroxyphenyl) ipiperazin-1-yl) phenyl)carbamate (CAS 184177-81-9) yi-Intermediate ye-Posaconazole (CAS 171228-49-2).I-Posaconazole i-spectrum ebanzi, isizukulwana sesibini, i-triazole edibeneyo kunye nomsebenzi we-antifungal.Yavunywa ukuba isetyenziswe kwezonyango e-United States ngoSeptemba 2006, kwaye iyafumaneka njengeyeza elenziwe lafana nelo lomenzi wechiza.I-Posaconazole lichiza le-triazole le-antifungal elithengiswa e-United States ngu-Schering-Plough phantsi kwegama lezorhwebo elithi Noxafil.I-Posaconazole isebenza ngokuphazamisa ukupakishwa okusondeleyo kwama-acyl chain of phospholipids, ukuphazamisa imisebenzi yeenkqubo ezithile ze-enzyme eziboshwe kwi-membrane ezifana ne-ATPase kunye ne-enzymes yenkqubo yokuthutha i-electron, ngaloo ndlela inqanda ukukhula kwefungi.Ikwenza oku ngokuthintela ukuhlanganiswa kwe-ergosterol ngokuvimbela i-enzyme i-lanosterol 14a-demethylase kunye nokuqokelela i-methylated sterol precursors.