I-Pirfenidone CAS 53179-13-8 Ubunyulu ≥99.0% IPF
Nikeza ngokucoceka okuphezulu, iMveliso yoRhwebo
Igama leKhemikhali: I-Pirfenidone
CAS: 53179-13-8
| Igama leMchiza | I-Pirfenidone |
| Izithethantonye | Perfenidone;I-5-Methyl-1-Phenylpyridine-2 (1H) -enye;PFD;S-7701;AMR-69 |
| Inombolo yeCAS | 53179-13-8 |
| Inombolo yeCAT | RF-API108 |
| Ubume beStokhwe | Ikhona evenkileni |
| Ifomula yeemolekyuli | C12H11NO |
| Ubunzima beMolekyuli | 185.22 |
| Indawo yokunyibilika | 96.0 ukuba 97.0℃ |
| Ukunyibilika | Inyibilika kwi-DMSO |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo weCrystalline oMhlophe ukuya koMthubi |
| Ukuchongwa | IR |
| Ubunyulu | ≥99.0% |
| Ilahleko ekomisweni | ≤0.50% |
| Uthuthu lweSulfated | ≤0.20% |
| Ukungacoceki Okukodwa | ≤0.50% |
| Ukungcola ngokupheleleyo | ≤1.0% |
| Iintsimbi ezinzima | ≤20ppm |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | API, Idiopathic Pulmonary Fibrosis (IPF) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
I-Pirfenidone (CAS: 53179-13-8) ikwiqela lamayeza abizwa ngokuba yi-antifibrotic agents.I-Pirfenidone ibonise umsebenzi kwiimeko ezininzi ze-fibrotic, kubandakanywa nemiphunga, izintso kunye nesibindi.Ichaphazela amajoni omzimba wakho kwaye inciphisa inani le-fibrosis (i-scarring) emiphungeni.I-Pirfenidone lelinye lamayeza amabini avunyiweyo eCanada ukunyanga i-Idiopathic Pulmonary Fibrosis (IPF).I-Pirfenidone iyi-inhibitor yokuvelisa i-TGF-β kunye ne-TGF-β evuselela ukuveliswa kwe-collagen, iyanciphisa ukuveliswa kwe-TNF-α kunye ne-IL-1β, kwaye iphinde ibe ne-anti-fibrotic kunye ne-anti-inflammatory properties.Yavunywa okokuqala eJapan kunyango lwezigulane ezine-idiopathic pulmonary fibrosis emva kwezilingo zeklinikhi, phantsi kwegama lezorhwebo likaPirespa nguShionogi, kwi-2008. Yavunywa ukuba isetyenziswe kwi-European Union kwi-2011, eCanada kwi-2012, nakwi-2012. eUnited States ngo-Oktobha 2014.
