Polymyxin B Sulfate CAS 1405-20-5 Assay Microbiological ≥6500 IU/mg Factory
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi wePolymyxin B Sulfate (CAS: 1405-20-5) enomgangatho ophezulu.Sinokubonelela nge-COA, ukuhanjiswa kwehlabathi jikelele, ubuninzi obuncinci kunye nobuninzi obukhoyo.Ukuba unomdla kwiPolymyxin B Sulfate,Please contact: alvin@ruifuchem.com
| Igama leMchiza | Polymyxin B Sulfate |
| Izithethantonye | Ityuwa yePolymyxin B Sulfate;iAerosporin;iMastimyxin;PXNS;PMB;I-Poly-RX |
| Ubume beStokhwe | KwiSitokhwe, Umthamo weMveliso iiToni ezili-10 ngonyaka |
| Inombolo yeCAS | 1405-20-5 |
| Ifomula yeemolekyuli | C55H96N16O13·2H2SO4 |
| Ubunzima beMolekyuli | 1301.56 |
| Indawo yokunyibilika | 217.0~220.0℃(dec.) |
| Inovakalelo | Hygroscopic.Unovelwano kuKhanya kunye noBushushu |
| Ukunyibilika kwamanzi | Inyibilika emanzini, 50 mg/mL.Inyibilika kancinane kwi-Ethanol |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Isampulu | Iyafumaneka |
| Uphawu | Ruifu Chemical |
| Izinto | Iinkcukacha | Iziphumo |
| Imbonakalo | Mhlophe okanye Phantse Nge-Crystalline Powder | Iyahambelana |
| Ukuchongwa A. Amaxesha okugcinwa kweencopho eziphambili ezivela kwisisombululo sesampuli zihambelana nezo zesisombululo esisemgangathweni, njengoko kufunyenwe kuvavanyo lokubunjwa kwePolymyxins. | Iyahambelana | |
| PH (2%) | 5.0~7.0 | 5.7 |
| PH (0.5%) | 5.0~7.5 | 5.5 |
| Uthuthu lweSulfate | ≤0.75% |
|
| Ukujikeleziswa okuthe ngqo [α]20/D | -78.0°~-90.0°(C=2, H2O) (Calcd. kwi-Anh. Substance) | -85.0 ° |
| Isulphate | 15.5 ~ 17.5% | 16.65% |
| Ilahleko ekomisweni | ≤6.00% | 3.0% |
| Intsalela kwi-Ignition | ≤0.10% | 0.02% |
| Iintsimbi ezinzima | ≤20ppm | ≤20ppm |
| Phenylalanine | 9.0~12.0% | 9.8% |
| Iyonke i-Viabel Aerobic Count | ≤10cfu/g | ≤10cfu/g |
| Izinto ezinxulumeneyo, i-HPLC |
|
|
| Ukungacoceki komntu | ≤3.0% | 2.723% |
| Ukungcola ngokupheleleyo | ≤17.0% | 16.223% |
| Uvavanyo lwe-HPLC (ODB) | Isimbuku seePolymyxins B1,B2,B3 kunye neB1-1: ≥80.0% | 86.6% |
| I-Polymyxin B3: ≤ 6.0% | 3.8% | |
| I-Polymyxin B1-1: ≤15.0% | 8.5% | |
| Uvavanyo, iMicrobiological (njengoko injalo) | ≥6500lU/mg | 8255IU/mg |
| Ubungakanani beNcam | ≥99.0% ≤30um ngevol | Iyahambelana |
| ≥90.0% ≤25um ngevol | ||
| ≥75.0%≤20um ngevol | ||
| ≥35.0%≤10um ngevol | ||
| Ukuqukumbela | Imveliso ihambelana ne-USP42 |
|
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Ukukhanya okulula.Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.Ayihambelani ne-oxidizing agents ezinamandla.
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Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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FLUKA BRAND F IIKHOWUDI 3-8-10
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Udidi lweeNgozi 6.1(b)
Ukupakisha Iqela III
I-Polymyxin liqela le-polypeptide antibiotics eveliswa yi-Bacillus polymyxa (bacilluspolymyxa).I-Polymyxin B kunye ne-E isetyenziselwa iinjongo zonyango, kwaye i-sulfates yazo isetyenziswa ngokuqhelekileyo.I-antibacterial spectrum kunye ne-clinical application ye-Polymyxin B Sulfate ifana ne-polymyxin E. Ine-inhibitory okanye i-bactericidal imiphumo kwi-gram-negative bacilli, njenge-Escherichia coli, i-Pseudomonas aeruginosa, i-paracilli, i-Klebsiella pneumoniae, i-acidophilus, i-pertussis kunye ne-Shigella.
I-Polymyxin Sulfate B ifana ne-polymyxin e, kwaye ine-inhibitory okanye i-bactericidal imiphumo kwi-gram-negative bacilli, njenge-e.coli, pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, bacilli pertussis kunye ne-dysentery bacilli.Isetyenziswa kakhulu enxebeni, kumchamo, iliso, indlebe, uqhoqhoqho kunye nezinye iindawo zosulelo olubangelwa yiPseudomonas aeruginosa kunye nezinye iPseudomonas.Ingasetyenziselwa i-sepsis kunye ne-peritonitis.Kwaye usulelo olubi olubangelwa yi-aminoglycosides, isizukulwana sesithathu se-cephalosporin-resistant bacteria, i-Pseudomonas aeruginosa okanye ezinye iibhaktheriya ezibuthathaka, ezifana ne-bacteremia, i-endocarditis, i-pneumonia, i-post-burn infection, njl.
1. I-intravenous drip: abantu abadala kunye nabantwana abanomsebenzi oqhelekileyo wezintso 1.5 ~ 2.5mg ngekhilogram yesisindo somzimba (ngokubanzi akukho ngaphezu kwe-2.5mg ngekhilogram yesisindo somzimba) ngosuku lwe-1, ihlukaniswe ngamaxesha e-2, i-drip kanye kwiiyure ze-12.Yonke i-50mg yale mveliso ihlanjululwe nge-500ml ye-5% yesisombululo se-glucose kwaye ihlanjululwe.Iintsana ezinomsebenzi oqhelekileyo wezintso ziyakwazi ukunyamezela i-4mg ngekhilogram yesisindo somzimba ngosuku lwe-1.2. I-injection ye-Intramuscular: abadala kunye nabantwana: 2.5 ~ 3mg ngekhilogram yesisindo somzimba kwi-1st, inikwe kwiibhetshi, kanye emva kwe-4 ~ 6 iiyure.Iintsana zinokufikelela kwi-4mg ngekhilogram yesisindo somzimba ngosuku kwaye iintsana ezisanda kuzalwa zinokufikelela kwi-4.5mg ngekhilogram yesisindo somzimba.3. Inaliti ye-Intrathecal (ye-Pseudomonas aeruginosa meningitis): i-5mg nge-milliliter yeyeza elimanzi elilungiselelwe ngenaliti ye-sodium chloride.Abantu abadala kunye nabantwana abangaphezu kweminyaka emi-2 ubudala, i-5mg imihla ngemihla, emva kweentsuku ezi-3-4 zokufaka isicelo, batshintshe kube kanye ngosuku, ubuncinane kwiiveki ezi-2, de inkcubeko ye-cerebrospinal fluid ingalunganga, kwaye umxholo weswekile uyinto eqhelekileyo.Kubantwana abangaphantsi kweminyaka eyi-2 ubudala, sebenzisa i-2mg kanye ngosuku kwi-3-4 iintsuku ezilandelelanayo (okanye i-2.5mg kanye ngosuku ngalunye), kwaye usebenzise i-2.5mg kanye ngosuku ngalunye de uvavanyo luqhelekileyo.4. Ukugxininiswa kwamaconsi kwamehlo yi-1 ~ 2.5mg nge-ml.
Gwema ukudibanisa kunye neziyobisi ezonakalisa izintso, i-skeletal muscle relaxants, i-aminoglycoside antibiotics, i-anesthetics enemiphumo ebonakalayo yokuphumla kwemisipha (njenge-enflurane), njl., kunye ne-quinine, i-magnesium, njl.I-Polymyxin B sulfate idityaniswe ne-sulfonamides, i-rifampicin, i-semi-synthetic penicillin, njl., kunyango losulelo olunamandla lwe-gram-negative lwebhaktiriya enganyangekiyo ngamachiza, kwaye isiphumo singcono kuneso sesicelo esinye.
I-1, abafazi abakhulelweyo nabancancisayo, abantwana, kunye nezigulana ezinokungasebenzi kakuhle kwezintso zixhaphake kakhulu.2. Le mveliso inetyhefu kakhulu kwaye inefuthe elibi lonyango kwintsholongwane enzulu.Ayilokhetho lokuqala kulo naluphi na usulelo.3. Isitofu esitofwayo sinokubangela ukudakumba kokuphefumla, nto leyo edla ngokungasetyenziswa.Ubuncinci isiqingatha sedosi yemihla ngemihla sifuna ukuthontsiza kwi-intravenous, hayi i-bolus ekhawulezayo kanye, ukuze ugweme ibhloko ebanzi ye-neuromuscular.4. Akufanele idibaniswe nezinye iziyobisi nge-nephrotoxicity okanye i-neuromuscular blockade ukuphepha iingozi.
Uphando lwe-Biochemical.I-Polymyxin B yi-anti-gram-negative bacilli polypeptide antibiotics, enokutshintsha isakhiwo se-membrane ukuvuza iimolekyuli ezincinci kwaye inqanda ukukhula kweebhaktheriya zegram-negative.Inefuthe le-bactericidal kwi-Escherichia coli.I-Lipid Iziqendu ezibotshelelwe kwiibhaktiriya lipopolysaccharides.Iipores ezincinci zinyanzelwa kwi-membrane yeseli yesikhumba yangaphandle.Indlela yesenzo: ibophelela kwaye iphazamise ukunyanzeliswa kwe-membrane ye-cytoplasmic.I-Antibacterial spectrum: ibhaktheriya e-Gram-negative.
Polymyxin B, Sulfate.
I-Polymyxin B Sulfate [1405-20-5].
» IPolymyxin B Sulfate yityuwa yesulfate yohlobo lwepolymyxin, into eveliswa kukukhula kweBacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae), okanye umxube weetyuwa ezimbini nangaphezulu.Inamandla angekho ngaphantsi kwe-6000 ye-Polymyxin B Units nge-mg, ibalwa kwisiseko esomileyo.
Ukupakishwa kunye nokugcinwa-Londoloza kwimigqomo eqinile, ekwazi ukumelana nokukhanya.
Ileyibhile-Apho ipakishelwe ukudityaniswa komyalelo kagqirha, ileyibhile ichaza inani lePolymyxin B Units kwisitya kunye ne-milligram nganye, ukuba ayenzelwanga ukusetyenziswa kwemveliso, ukuba ayinyumba, kwaye amandla ayo angenakuqinisekiswa ixesha elide kune-60. iintsuku emva kokuvulwa.Apho ijongwe ukuba isetyenziswe ekulungiseleleni iifom zedosi etofwayo okanye ezinye iintsholongwane, ileyibhile ichaza ukuba ayinyumba okanye kufuneka iphinde iqwalaselwe ngexesha lokulungiswa kweedosi ezitofwayo okanye ezinye iifom zedosi engenazintsholongwane.
Imigangatho yezalathiso ye-USP <11>-
USP Polymyxin B Sulfate RS
Isazisi-
A: UVavanyo lweChromatographic yeLiquid-
Isigaba seselula-Lungisa umxube we-0.1 M tribasic sodium phosphate kunye ne-acetonitrile (77:23), kwaye ulungelelanise ne-phosphoric acid kwi-pH ye-3.0.Yenza uhlengahlengiso xa kukho imfuneko (jonga ukufaneleka kweNkqubo phantsi kweChromatography <621>.
Isisombululo esisemgangathweni-Lungisa isisombululo se-USP Polymyxin B Sulfate RS kwisigaba se-Mobile ene-concentration malunga ne-3.5 mg nge-mL.Khusela esi sisombululo ekukhanyeni.
Isisombululo sovavanyo-Lungisa isisombululo se-Polymyxin B Sulfate kwisigaba se-Mobile esinogxininiso malunga ne-3.5 mg nge-mL.Khusela esi sisombululo ekukhanyeni.
Inkqubo yeChromatographic (jonga i-Chromatography <621>)-I-chromatograph yolwelo ixhotyiswe nge-212-nm detector kunye ne-4.6-mm × 25-cm ikholamu equlethe i-5-µm yokupakisha i-L1.Izinga lokuhamba malunga ne-1 mL ngomzuzu.
Inkqubo-Ngokwahlukileyo tofa imithamo elinganayo (malunga ne-10 µL) yoMgangatho wesisombululo kunye nesisombululo soVavanyo kwichromatograph, kwaye urekhode iichromatogram.I-chromatogram efunyenwe kwisisombululo soVavanyo ihambelana ngokusemgangathweni naleyo ifunyenwe kwisisombululo esiPhakathi, esibonisa incopho enkulu ehambelana ne-polymyxin B1 kunye neencopho ngamaxesha okugcinwa okumalunga ne-0.5 (polymyxin B2) kunye ne-0.6 (i-polymyxin B3).
B: Dlulisa i-2 mg kwi-5 mL yamanzi, yongeza i-5 mL ye-2.5 N i-sodium hydroxide, xuba, kwaye ungeze amaconsi ama-5 esisombululo se-cupric sulfate (1 kwi-100), ukugubha emva kokongezwa kwethontsi ngalinye: umbala obomvu obomvu uveliswa. .
C: Isisombululo (1 kwi-20) sihlangabezana neemfuno zeemvavanyo zeSulfate <191>.
pH <791>: phakathi kwe-5.0 kunye ne-7.5, kwisisombululo esiqulethe i-5 mg nge-mL.
Ilahleko ekumiseni <731> -Yomile malunga ne-100 mg, ilinganiswe ngokuchanekileyo, kwibhotile ye-capillary-stoppered kwi-vacuum kwi-60 ℃ kwiiyure ze-3: ilahlekelwa ngaphezu kwe-7.0% yobunzima bayo.
Umxholo we-phenylalanine-Dlulisa malunga ne-0.375 g ye-Polymyxin B Sulfate, ilinganiswe ngokuchanekileyo, kwi-flask ye-volumetric ye-100-mL, ichithe kwaye ihlambulule nge-0.1 N i-hydrochloric acid ukuya kwivolumu, kwaye ixube.Ukulinganisa i-absorbences yesi sisombululo kwi-maxima malunga ne-264 nm (A264), 258 nm (A258), kunye ne-252 nm (A252), kunye ne-absorbents kwi-280 nm (A280) kunye ne-300 nm (A300).Bala ipesenti yephenylalanine kwinxalenye yePolymyxin B Sulfate ethathwe ngefomula:
(9.4787/W) (A258 – 0.5A252 + 0.5A264 – 1.84A280 + 0.8A300)
apho u-W ubunzima, kwi-g, ye-Polymyxin B Sulfate ethathiweyo: iqulethe phakathi kwe-9% kunye ne-12% ye-phenylalanine, ibalwa ngesiseko esomileyo.
Ezinye iimfuneko- Ukuba ngomyalelo kagqirha wokudibanisa, iyahlangabezana neemfuno zeNtsalela ekutshisweni phantsi kwePolymyxin B yokuTofwa.Apho ileyibhile ichaza ukuba iPolymyxin B Sulfate ayinyumba, ihlangabezana neemfuno zovavanyo lweNzala <71> kwaye, apho kujongwe khona iifom zesitofu esitofwayo, kwiPyrogen phantsi kwePolymyxin B ye-Injection.Apho ileyibhile ichaza ukuba i-Polymyxin B Sulfate kufuneka ifakwe kwi-processing eyongezelelweyo ngexesha lokulungiswa kweefom zedosi yokutofwa, ihlangabezana neemfuno zePyrogen phantsi kwePolymyxin B ye-Injection.
I-Assay-Qhubeka ngePolymyxin B Sulfate njengoko ilawulwa phantsi kwe-Antibiotics-Microbial Assays <81>.
