Posaconazole CAS 171228-49-2 API Factory Triazole Antifungal Agent High Quality
IFactory Supply Posaconazole Related Intermediates, Commercial Production
I-Posaconazole CAS 171228-49-2
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1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine CAS 74853-08-0
2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal CAS 170985-85-0
I-Diethyl L-(+)-Tartrate CAS 87-91-2
Igama leMchiza | Posaconazole |
Izithethantonye | I-POS;I-SCH 56592;4- [4--[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl] methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-enye |
Inombolo yeCAS | 171228-49-2 |
Inombolo yeCAT | RF-API77 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
Ifomula yeemolekyuli | C37H42F2N8O4 |
Ubunzima beMolekyuli | 700.78 |
Ukuxinana | 1.36 g/cm3 |
Ukunyibilika | Inyibilika kwi-DMSO, Ayinyibiliki emanzini |
Imeko yokuthumela ngenqanawa | Ithunyelwe Ngaphantsi Kweqondo Lobushushu Le-Ambient |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder |
Isazisi A | IR: I-infrared absorption spectrum yemveliso kufuneka ihambelane naleyo yereferensi yezinto. |
Isazisi B | Ixesha logcino lwe-HPLC liyafana nereferensi yento |
Indawo yokunyibilika | 167.0 ~ 171.0℃ |
Ukujikeleziswa okuthe ngqo [a]20 | -24.0° ~ -28.0° (C=1, CHCL3) |
Amanzi (KF) | ≤1.0% |
Intsalela kwi-Ignition | ≤0.10% |
Izinto ezinxulumeneyo | |
HT 909-24 | ≤0.20% |
Nakuphi na Ukungacoceki komntu | ≤0.10% |
Ukungcola ngokupheleleyo | ≤1.0% |
Izinyibilikisi ezishiyekileyo | |
IMethanol | ≤3000ppm |
I-Methyl tert-Butyl Ether | ≤5000ppm |
Isopropanol | ≤5000ppm |
I-Dimethyl Sulfoxide | ≤5000ppm |
Dichloromethane | ≤600ppm |
Isivavanyi | 98.0% ~ 102.0% (Ibalwe kwisiseko somisiwe) |
Iintsimbi ezinzima | ≤10ppm |
Isomer | I-Enantiomer ≤0.10% |
Nakuphi na Ukungacoceki komntu ≤0.10% | |
Ukungcola ngokupheleleyo ≤1.0% | |
Umgangatho woVavanyo | uMgangatho woShishino;USP;BP;EP Umgangatho |
Ukusetyenziswa | I-API, i-Agent ye-Antifungal ye-Triazole |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Posaconazole (i-CAS 171228-49-2), i-spectrum ebanzi, isizukulwana sesibini, i-triazole edibeneyo kunye nomsebenzi we-antifungal, eyasungulwa e-UK, ilungu elitsha leklasi ye-azole ye-antifungal agents ukufikelela kwimarike.Iboniswa kunyango kunye ne-prophylaxis yoluhlu lwezifo zefungal ezihlaselayo, ezibandakanya i-aspergillosis, i-fusariosis, i-chromoblastomycosis, i-mycetoma, kunye ne-coccidiomycosis kwizigulane eziphikisayo, okanye ezinganyamezeliyo, unyango oluqhelekileyo kunye ne-amphotericin B kunye / okanye i-itraconazole.E-US, ivunyiwe iprophylaxis yosulelo lwe-Aspergillus kunye neCandida kwizigulana ezineminyaka eli-13 ubudala ezisemngciphekweni omkhulu wokufumana olu sulelo ngenxa yokungakhuseleki kakhulu.Ukongezelela, kuvunyelwe unyango lwe-oropharyngeal candidiasis.I-Posaconazole ine-spectrum eyandisiweyo yomsebenzi ngaphezu kwamanye amalungu e-azole antifungals.Ukongeza kumsebenzi onamandla ngokuchasene neemeko eziphikisayo ze-aspergillosis kunye ne-fluconazole-resistant Candida, ibonisa umsebenzi ochasene neZygomycetes.I-Posaconazole lichiza le-triazole le-antifungal elithengiswa e-United States ngu-Schering-Plough phantsi kwegama lezorhwebo elithi Noxafil.