I-Pyridine-3-Sulfonyl Chloride CAS 16133-25-8 Ubunyulu ≥98.5% (GC) iVonoprazan Fumarat Intermediate Factory
Ukubonelela ngeVonoprazan Fumarate kunye neNxulumano ePhakathi
5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde CAS 881674-56-2
I-Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
I-Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
Igama leMchiza | I-Pyridine-3-Sulfonyl Chloride |
Izithethantonye | 3-Pyridinesulfonyl Chloride;3-Pyridylsulfonyl Chloride;m-Pyridinesulfonyl Chloride;I-Piperidine-3-Sulfonylchloride |
Inombolo yeCAS | 16133-25-8 |
Inombolo yeCAT | RF-PI540 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C5H4ClNO2S |
Ubunzima beMolekyuli | 177.61 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Ulwelo olungenambala okanye oluMthubi |
Ubunyulu / Indlela yokuHlalutya | ≥98.5% (GC) |
Indawo yokubilisa | 110.0 ~ 112.0℃/2mm Hg |
Ukungacoceki Okukodwa | ≤0.50% |
Ukungcola ngokupheleleyo | ≤1.5% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Umbindi weVonoprazan Fumarate (CAS: 1260141-27-2) |
Iphakheji: Ibhotile, 25kg / umphanda, okanye ngokwemfuno umthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-Pyridine-3-Sulfonyl Chloride (i-CAS: 16133-25-8) iphakathi kweVonoprazan Fumarate (CAS: 1260141-27-2).I-Vonoprazan Fumarate, efunyenwe kwaye yaphuhliswa ngu-Takeda no-Otsuka, yavunywa yi-PMDA yaseJapan ngoDisemba 2014, kwaye ibonakaliswe kunyango lwesilonda sesisu, isilonda se-duodenal kunye ne-reflux esophagitis.I-Vonoprazan fumarate inendlela inoveli yesenzo ebizwa ngokuba yi-potassium-competitive acid blockers, ekhuphisana ngokunqanda ukubophelela kwe-ion ye-potassium kwi-H +, i-K + -ATPase (eyaziwa ngokuba yimpompo yeproton) kwinqanaba lokugqibela lokukhutshwa kwe-asidi yesisu kwiiseli ze-parietal zesisu.I-Vonoprazan ayivimbeli umsebenzi we-Na +, i-K + -ATPase nakwizigxina ze-500 ngamaxesha aphakamileyo ngaphezu kwexabiso labo le-IC50 ngokumelene ne-gastric H +, K + -ATPase umsebenzi.Ngaphezu koko, iyeza alichatshazelwa yi-gastric secretory state, ngokungafaniyo neePPI.