(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Ubunyulu ≥99.7% (GC) Ucoceko lweChiral ≥99.7% Panipenem kunye neDarifenacin hydrobromide Intermediate
Ubonelelo lwabavelisi;Ukucoceka okuphezulu kunye neXabiso loKhuphiswano
I-Shanghai Ruifu Chemical Co., Ltd. Ubonelelo ngezoRhwebo kwiiCompounds zeChiral:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S) -3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Phakathi kwePanipenem (CAS 87726-17-8) kunye neDarifenacin hydrobromide (CAS 133099-07-7)
| Igama leMchiza | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Izithethantonye | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Inombolo yeCAS | 104706-47-0 |
| Inombolo yeCAT | RF-CC102 |
| Ubunyulu / Indlela yokuHlalutya | ≥98.0% (GC) |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C4H10ClNO |
| Ubunzima beMolekyuli | 123.58 |
| Indawo yokunyibilika | 107.0 ~ 111.0 °C |
| Ukunyibilika emanzini | Phantse Ukungafihli |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Okumhlophe-kuMhlophe ukuya kwiPowder yeCrystalline eNyucu emdaka |
| Ubunyulu / Indlela yokuHlalutya | ≥99.7% (GC) |
| Ucoceko lweChiral | ≥99.7% ee |
| Intsalela kwi-Ignition | ≤0.50% |
| Ukujikeleziswa okuthe ngqo [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Nakuphi na Ukungacoceki komntu | ≤0.20% |
| Ukungcola okupheleleyo | ≤0.30% |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | abaPhakathi bamayeza;IiCompounds zeChiral |
Indlela yokuhlalutya
Isixhobo: isixhobo seGC (Shimadzu GC-2010)
Uluhlu: DB-17 Agilent 30mX0.53mmX1.0μm
Ubushushu bokuqala be-oveni: 80℃
Ixesha lokuqala 2.0min
Ireyithi ye-15℃/min
Ubushushu bokugqibela be-oveni: 250 ℃
Ixesha lokugqibela 20min
Irhasi yokuthwala iNitrojeni
Imowudi Ukuhamba rhoqo
Ukuhamba 5.0mL / min
Ukwahlula umlinganiselo 10:1
Ubushushu be-injector: 250℃
Ubushushu besixhobo: 300℃
Umthamo wokutofa 1.0μL
Amanyathelo okufuneka athathwe ngaphambi kohlalutyo:
1. Ikholam yemeko kwi-240℃ ubuncinci bemizuzu engama-30.
2. Hlamba isirinji kwaye ucoce i-injector liner ngokufanelekileyo ukususa ukungcola kohlalutyo lwangaphambili.
3. Hlamba, womise kwaye ugcwalise i-diluent kwiibhotile zesirinji.
Amalungiselelo okunciphisa:
Lungiselela i-2% w / v isisombululo se-sodium hydroxide emanzini.
Ulungiselelo olusemgangathweni:
Ubunzima malunga ne-100mg ye (R) -3-hydroxyprrolidine hydrochloride umgangatho kwi-vial, yongeza i-1mL ye-diluent kwaye udibanise.
Ukulungiselela uvavanyo:
Ubunzima malunga ne-100mg yesampuli yovavanyo kwi-vial, yongeza i-1mL ye-diluent kwaye unyibilikise.Lungiselela kabini.
Inkqubo:
Ukutofa okungenanto (i-diluent), ukulungiswa okusemgangathweni kunye nokulungiswa kovavanyo usebenzisa iimeko ezingaphezulu kwe-GC.Ukungahoyi iincopho ngenxa yokungenanto.Ixesha lokugcinwa kwencopho ngenxa (R) -3-hydroxyprrolidine malunga ne-5.0min.
Phawula:
Xela iziphumo njenge-avareji
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) enomgangatho ophezulu, esetyenziswa ngokubanzi kwi-organic synthesis, i-synthesis ye-pharmaceutical intermediates. kunye ne-Active Pharmaceutical Ingredient (API) synthesis.
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) yindawo ephakathi ngokuqhelekileyo kwi-synthesis yePanipenem (CAS 87726-17-8) kunye neDarifenacin hydrobromide (CAS 133099-07-7).
(R) - (-) -3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) i-chiral hydroxy derivative ye-pyrrlodine esetyenziselwa ukulungiswa kwe-chiral niologically active compounds ezifana ne-muscarinic receptor antagonists kunye ne-antimicrobial agents.
Indlela ye-Synthesis ye-(R) -3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile yaphendulwa kunye ne-trimethyl chlorosilane kwi-solvent ye-dichloromethane ukufumana (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine emva koko i-hydrogenated kwi-Pd / C catalyst. (R) -3-trimethylsiloxyepyrrolidine yafunyanwa ngonyango lokuvala i-sodium hydroxide ring.Ekugqibeleni, i-(R) -3-hydroxypyrrolidine hydrochloride imveliso yafunyanwa ngonyango olugxininisiweyo lwe-hydrochloric acid kunye neqela elikhuselayo le-trimethylsilyl lisusiwe.
