(R)-Lansoprazole Dexlansoprazole CAS 138530-94-6 Assay 98.0~102.0% (HPLC) Factory
I-Ruifu Chemical Supply Lansoprazole Intermediates
ILansoprazole CAS 103577-45-3
ILansoprazole Chloride Compound CAS 127337-60-4
(R)-Lansoprazole Dexlansoprazole CAS 138530-94-6
Igama leMchiza | (R)-Lansoprazole |
Izithethantonye | R-(+)-Lansoprazole;Dexlansoprazole;2-[(R)-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole;T 168390;THATHA 390;Ukungcola kweLansoprazole 14;Ukungcola okuNxulumene neDexlansoprazole 2;(R) -2-[[[3-Methyl-4- (2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl] -1H-Benzimidazole; |
Inombolo yeCAS | 138530-94-6 |
Inombolo yeCAT | RF-PI1916 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C16H14F3N3O2S |
Ubunzima beMolekyuli | 369.36 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder |
Ukunyibilika | I-Soluble kwi-Dimethylformamide, iphantse inganyibiliki emanzini |
Ukucaca kunye nombala wesisombululo | Iyahlangabezana neMfuneko |
Ukuchongwa kwe-IR | I-infrared absorption spectrum kufuneka ihambelane nereferensi yento |
Ukuchongwa kwe-HPLC | Ixesha lokugcinwa kwencopho ephambili kufuneka lihambelane naleyo yereferensi |
Ukujikeleziswa okuthe ngqo | +142.0°~+149.0° |
Indawo yokunyibilika | ~140.0℃ |
Isiqulatho samanzi (KF) | <1.00% |
Intsalela kwi-Ignition | <0.10% |
Ukungcola Okunxulumeneyo | (HPLC) |
Ii-nitrogen oxides | <0.10% |
Sulfone | <0.40% |
Sulfidi | <0.20% |
Nakuphi na Okunye Ukungcola Okukodwa | <0.10% |
Ukungcola ngokupheleleyo | <0.60% |
Ukucoceka kwamehlo (HPLC) | >99.5% |
Isivavanyi | 98.0~102.0% (HPLC, %w/w, kwisiseko se-anhydrous, i-solvent-free) |
Iintsimbi ezinzima | <10ppm |
Izinyibilikisi ezishiyekileyo | |
Toluene | <890ppm |
n-Heptane | <5000ppm |
I-Endotoxin yebhaktiriya | <2.5EU/mg |
Umgangatho woVavanyo | Umgangatho we-USP;Pharmacopoeia yaseTshayina |
Ukusetyenziswa | API;I-Proton Pump Inhibitor esebenzayo ngomlomo |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
(R) -Lansoprazole (CAS: 138530-94-6) yiR enantiomer yeLansoprazole, iLansoprazole (AG 1749) yiproton pump inhibitor esebenzayo ngomlomo ekhusela isisu ekuveliseni i-asidi.I-Dexlansoprazole ye-Lansoprazole dextroisomer, luhlobo lwamachiza e-anti peptic ulcer kwi-derivatives ye-benzimidazole endaweni, kwisakhiwo semolekyuli kwi-element fluorine, i-proton pump inhibitors yesibini emva kwe-omeprazole.I-Dexlansoprazole inefuthe lokuthintela ukukhutshwa kwe-asidi yesisu, umphumo ungcono kunezinye iziyobisi (i-Omeprazole, i-Pantoprazole, i-Rebela, i-Tetrazolium) inokuthintela kakhulu ukwenzeka kwesilonda.Ingaphezulu kwe-famotidine okanye i-Omeprazole yomonakalo we-alcohol induced gastric mucosa kunye ne-duodenal ulcer ebangelwa ikakhulu yi-acid hypersecretion.Ukongeza, imveliso inefuthe elifanayo le-anti Helicobacter pylori njengokulungiswa kwe-bismuth, kwaye isetyenziselwa i-reflux esophagitis kunye ne-Zhuo AI syndrome.I-Takeda Pharmaceuticals ifumene imvume ye-dexlansoprazole, i-dual release formulation ye (R) -isomer ye-lansoprazol proton pump inhibitor (PPI) esele ikwimarike, ukusuka kwi-FDA ngoJanuwari 2009. I-Dexlansoprazole ilibaziseka ukukhulula i-capsule ukwenzela ukuba kanye ngosuku, unyango lomlomo. isitshisa esinxulumene nesifo se-reflux ye-non-erosive gastroesophageal (GERD), ukuphiliswa kwe-erosive esophagitis (EE) kunye nokugcinwa kwe-EE ephilileyo.