I-Ramelteon (TAK-375) CAS 196597-26-9 Ubunyulu > 99.5% (HPLC)
UMvelisi oPhambili kunye noMboneleli, abaPhakathi beRamelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-enye CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
I-Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com
| Igama leMchiza | Ramelteon |
| Izithethantonye | (S)-N-[2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethyl]propionamide;I-TAK-375;I-TAK375;TAK 375;Rozerem |
| Inombolo yeCAS | 196597-26-9 |
| Inombolo yeCAT | RF2885 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C16H21NO2 |
| Ubunzima beMolekyuli | 259.35 |
| Indawo yokunyibilika | 113.0 ukuba 116.0℃ |
| Indawo yokubilisa | 455.3±24.0℃ |
| Ukuxinana | 1.119±0.06 g/cm3 |
| Ukujikeleziswa okuthe ngqo [α]20/D | -55.0 ° ukuya -60.0 ° (C=1, CHCL3) |
| Ukunyibilika emanzini | Ayinyibiliki emanzini (11 mg/l 25℃) |
| Ukunyibilika | Inyibilika kwi-Ethanol, iMethanol, iDMSO |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo weCrystalline oMhlophe |
| Ubunyulu / Indlela yokuHlalutya | >99.5% (HPLC) |
| Indawo yokunyibilika | 113.0 ~ 116.0℃ |
| Ilahleko ekomisweni | <0.50% |
| Intsalela kwi-Ignition | <0.10% |
| Isomer Ucoceko | <0.10% |
| Iintsimbi ezinzima | <10ppm |
| Ubumuncu okanye i-alkalinity | Vumelana |
| I-Ethanol | <5000ppm |
| Ukungacoceki Okukodwa | <0.20% |
| Ukungcola ngokupheleleyo | <0.50% |
| I-Infrared Spectrum | Iyahambelana neSakhiwo |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | I-API, evunyiweyo yoNyango lokungalali |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
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I-Ramelteon (i-CAS: 196597-26-9) yamkelwa okokuqala yi-US Food and Drug Administration (FDA) ngoJulayi 22, 2005, emva koko yamkelwa yi-Arhente ye-Pharmaceuticals and Medical Devices Agency (PMDA) ngo-Apr 16, 2010. Yaphuhliswa kwaye ithengiswe njengeRozerem® nguTakeda,ingasetyenziselwa ukunyanga ukuphuthelwa ngobunzima bokulala, kwaye ineziphumo eziqinisekileyo zokuphuthelwa okungapheliyo kunye nokuphuthelwa kwexesha elifutshane.Le mveliso inokukhetha ngokukhetha uhlobo lwe-1 kunye nohlobo lwe-2 i-receptors ye-melatonin (MT1, MT2), ukwandisa ukulala okucothayo (SWS) kunye nokulala kwamehlo okukhawulezayo (REW), ngaloo ndlela kuncitshiswe ukulala.I-Ramelteamide lichiza lokuqala lonyango lokungalali elingekho phantsi kolawulo olulodwa.Le mveliso yi-agonist ye-melatonin receptor.Inobudlelwane obuphezulu kunye ne-melatonin MT1 kunye ne-MT2 i-receptors, kwaye inefuthe elithile kunye elipheleleyo le-agonistic kwi-MT1 kunye ne-MT2 receptors, kodwa ayisebenzi kunye ne-MT3 receptor.Ukongezelela, ayibopheleli kwii-neurotransmitter receptors ezifana ne-GABA receptor complexes, kwaye ayiphazamisi umsebenzi wee-enzyme ezininzi ngaphakathi koluhlu oluthile.Ngoko ke, inokuphepha ukuphazamiseka okuhambelana neziyobisi ze-GABA (ezinokubangela iingozi zemoto, ukuwa kunye nokuphuka).njl.njl) kunye nokuba likhoboka leziyobisi kunye nokuxhomekeka.I-Rozerem® ifumaneka njenge-tablet-coated tablet yokusetyenziswa ngomlomo, equkethe i-8 mg ye-Ramelteon yamahhala.Idosi ecetyiswayo yabantu abadala yi-8 mg ethathwe kwimizuzu engama-30 yokulala.
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