Ramelteon Intermediate 12 CAS 1053239-39-6 Ubunyulu > 98.0% (HPLC)

Inkcazelo emfutshane:

Igama leMchiza: 2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride

Izithethantonye: Ramelteon Intermediate 12

CAS: 1053239-39-6

Ubunyulu: >98.0% (HPLC)

Imbonakalo: Mhlophe ukuya kuMhlophe-umgubo oqinileyo

Umbindi weRamelteon (CAS: 196597-26-9)

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

UMvelisi oPhambili kunye noMboneleli, abaPhakathi beRamelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-enye CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
I-Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride
Izithethantonye	I-Ramelteon ePhakathi 12;Ramelteon Stage-2 Ukungcola;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B]Furan-8-Ethanamine Hydrochloride
Inombolo yeCAS	1053239-39-6
Inombolo yeCAT	RF2887
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C13H18ClNO
Ubunzima beMolekyuli	239.74
Indawo yokunyibilika	165.0 ~ 167.0℃
Ukuxinana	1.058±0.06 g/cm3
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oqinileyo oMhlophe ukuya koMhlophe
Ubunyulu / Indlela yokuHlalutya	>98.0% (HPLC)
Ilahleko ekomisweni	<1.00%
Ukungacoceki Okukodwa	<1.00%
Ukungcola ngokupheleleyo	<2.00%
I-1 H NMR Spectrum	Ukungqinelana Nolwakhiwo
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Umbindi weRamelteon (CAS: 196597-26-9)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

Umthamo owaneleyo: Izixhobo ezaneleyo kunye namagcisa

Inkonzo yobuNgcali: Inkonzo enye yokuyeka ukuthenga

Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

Inkonzo yesiNtu yoHlanganiso: Isuka kwiigram ukuya kwiikhilos

Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.

Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.

Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.

UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.

Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.

Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.

MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.

Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.

Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.

Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.

Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.

Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.

Isicelo:

I-2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride (CAS: 1053239-39-6) iphakathi kweRamelteon (CAS: 196597- 26-9).Ngokungafaniyo nonyango oluninzi lokungalali olujolise kwi-GABA (g-aminobutyric acid) i-receptor complex, i-Ramelteon i-agonist ye-melatonin receptor.Ngokukodwa, inokukhethwa okuphezulu kwe-MT1 kunye ne-MT2 subtypes, eziye zabandakanyeka ekugcinweni kwe-circadian rhythms, phezu kwe-MT3 receptor ejongene neminye imisebenzi ye-melatonin.Ukunqongophala kwayo kobudlelwane kungekuphela nje kwi-GABA receptor complex kodwa kunye ne-neurotransmitter, i-dopaminerigic, i-opiate, kunye ne-benzodiazepine receptors iphakamisa iprofayili yokhuseleko ephuculweyo engenakho ukusetyenziswa kakubi kweziyobisi ze-hypnotic ezijolise kwezi zamkeli.Ngaloo ndlela, iRamelteon ayilochiza elicwangcisiweyo.I-metabolites eziphambili ziquka i-hydroxylation kunye ne-oxidation kwiintlobo ze-carbonyl kunye ne-metabolites yesibini ephuma kwi-glucuronidation.Ekubeni i-CYP1A2 iyona isozyme enkulu echaphazelekayo kwi-hepatic metabolism ye-Ramelteon, akufanele ithathwe ngokudibanisa ne-CYP1A2 inhibitors enamandla, njenge-fluvoxamine.Ukusetyenziswa ngokubambisana kunye nokuba yi-ketoconazole (i-CYP3A4 inhibitor) okanye i-fluconazole (i-CYP2C9 inhibitor enamandla) ibangele ukunyuka okubonakalayo kwi-AUC kunye ne-Cmax, kodwa i-metabolism ebanzi kunye noxinzelelo oluphezulu lwe-plasma ye-Ramelteon luthintele isidingo sokuguqulwa kwethamo.Iphakheji yokufaka iphakheji, nangona kunjalo, ilumkisa izigulane malunga nokulawula ngokubambisana kunye ne-CYP3A4 enamandla kunye ne-CYP2C9 inhibitors.Ngokusekelwe kwisiphumo solingo lwezonyango, idosi ecetyiswayo ye-Ramelteon yi-8mg ethathwe ngaphakathi kwe-30 min ukuya kulala.Ukongeza kwi-precaution ye-co-administration kunye ne-CYP inhibitors, akufanele isetyenziswe kwizigulane ezinokukhubazeka okukhulu kwesibindi.Iziganeko ezimbi, ezibonwe kwi-5% yezigulana kwizifundo zeklinikhi, yayingalali, isiyezi, isicaphucaphu, ukudinwa, intloko ebuhlungu, kunye nokuphuthelwa.