Rapamycin Sirolimus RAPA CAS 53123-88-9 Assay ≥98.5% API Factory High Purity
Umenzi onobunyulu obuPhezulu kunye noMgangatho oZinzile
Igama leKhemikhali: Rapamycin;iSirolimus;I-RAPA
CAS: 53123-88-9
Macrolide Immunosuppressive Agent
Umgangatho ophezulu we-API, iMveliso yoRhwebo
Igama leMchiza | I-Rapamycin |
Izithethantonye | iSirolimus;I-RAPA;AY-22989 |
Inombolo yeCAS | 53123-88-9 |
Inombolo yeCAT | RF-API59 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
Ifomula yeemolekyuli | C51H79NO13 |
Ubunzima beMolekyuli | 914.19 |
Indawo yokunyibilika | 183.0 ~ 185.0℃ |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo weCrystalline oMhlophe okanye oMhlophe |
Isazisi A | Uluhlu lwe-IR ye-potassium bromide yokulungiswa kwesampulu ibonisa ubuninzi kumaza obude obufanayo naleyo yolungiselelo olufanayo lomgangatho wereferensi yangaphakathi. |
Isazisi B | I-UV spectrum ye-95% yokulungiswa kwe-ethanol yesampulu ibonisa ubukhulu be-267nm, 277nm, 288nm njengaleyo yolungiselelo olufanayo lomgangatho wereferensi yangaphakathi. |
Isazisi C | Ixesha lokugcinwa kweencopho ze-trans-kunye ne-cis-stereoisomers kwichromatogram yolungiselelo lovavanyo lihambelana nekhromatogram yolungiselelo oluqhelekileyo, njengoko lufunyenwe kuvavanyo. |
Ukujikeleziswa kwe-Optical | -147.0 ° ~ -157.0 ° |
Ilahleko ekomisweni | ≤0.50% |
Intsalela kwi-Ignition | ≤0.20% |
Iintsimbi ezinzima | ≤20ppm |
Ukungacoceki komntu | ≤1.5% |
Ukungcola ngokupheleleyo | ≤2.0% (ngaphandle kweCis-Stereoisomer yeSirolimus) |
Cis-Stereoisomer of Sirolimus | ≤5.0% |
Izinyibilikisi ezishiyekileyo | |
I-Ethanol | ≤5000ppm |
I-Ethyl Acetate | ≤5000ppm |
Cyclohexane | ≤5000ppm |
I-acetone | ≤5000ppm |
I-Diethyl Ether | ≤5000ppm |
Isivavanyi | ≥98.5% (Ibalwe i-trans- kunye ne-cis-stereoisomer ye-sirolimus ngokwe-dired basis) |
Umgangatho woVavanyo | I-Pharmacopoeia yaseTshayina (CP);Umgangatho woShishino |
Ukusetyenziswa | I-Active Pharmaceutical ingredient (API) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Rapamycin (i-Sirolimus; i-AY 22989) yi-activator ye-autophagy, uhlobo olutsha lwe-macrolide immunosuppressive agent eneziphumo ezilungileyo zokunyanga, ubuthi obuphantsi, kwaye akukho nephrotoxicity.Ingasetyenziselwa ukugcina i-immunity yamalungu okutshintshwa (ingakumbi kukutshintshwa kwezintso) ukunciphisa ukulahlwa kwe-immunological emva kotyando lokutshintshwa kwelungu.