I-Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Umgangatho oPhakamileyo onguMfanekiso oFanelweyo

Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Umgangatho oPhezulu

Inkcazelo emfutshane:

Igama leMchiza: Remdesivir (GS-5734)

CAS: 1809249-37-3

Imbonakalo: Mhlophe ukuya kuMhlophe-umgubo oqinileyo

Uvavanyo: 98.0% ~ 102.0%

I-Remdesivir yonyango lwe-COVID-19

Umgangatho ophezulu we-API, iMveliso yoRhwebo

Inquiry: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ubonelelo ngezoRhwebo loMvelisi i-Remdesivir kunye nabaPhakathi abaNxulumeneyo nabanoMgangatho oPhezulu
I-Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
I-Trimethylsilyl Cyanide CAS 7677-24-9
I-4-Nitrophenol CAS 100-02-7
I-2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
I-Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
I-Remdesivir N-2 ePhakathi CAS 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
I-Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1

Iipropati zeMichiza:

Igama leMchiza	I-Remdesivir
Izithethantonye	GS-5734;2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano -3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Inombolo yeCAS	1809249-37-3
Inombolo yeCAT	I-RF-API96
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram
Ifomula yeemolekyuli	I-C27H35N6O8P
Ubunzima beMolekyuli	602.58
Ukuxinana	1.47±0.1 g/cm3
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oqinileyo oMhlophe ukuya koMhlophe
Isazisi A	IR: I-infrared absorption spectrum yemveliso kufuneka ihambelane naleyo yereferensi yezinto.
Isazisi B	Ixesha logcino lwe-HPLC liyafana nereferensi yento
Ukujikeleziswa okuthe ngqo	-19.0 ° ~ -22.0 °
Ukunyibilika	I-Solun kwi-Methanol, iNyibilika kancinane kwi-Ethanol, iNyibilika kancinane kwi-acetonitrile, ayiNyibiliki ngokuthe ngqo emanzini.
Izinto ezinxulumeneyo
Nakuphi na Ukungacoceki komntu	≤0.10%
Ukungcola ngokupheleleyo	≤1.0%
I-RD-3.1	≤0.10%
RD-C	≤0.10%
RD-D	≤0.10%
RD-E	≤0.10%
RP-Isomer	≤0.10%
Nitrophenol	≤0.10%
Izinyibilikisi ezishiyekileyo
I-Methanol Dichloride	≤6000ppm
I-acetone	≤5000ppm
Isopropyl Utywala	≤5000ppm
Acetonitrile	≤410ppm
Dichloromethane	≤600ppm
I-Methyl tert Butyl Ether	≤5000ppm
I-Ethyl Acetate	≤5000ppm
Tetrahydrofuran	≤720ppm
n-Heptane	≤5000ppm
Isivavanyi	98.0% ~ 102.0% (Ibalwe kwisiseko somisiwe)
Ubalo lweAerobic iyonke
Intsholongwane yeAerobic	≤100cfu/g
Igwele kunye noMngundo	≤10cfu/g
E. Ikhoyili	Ibi
I-Endotoxin yebhaktiriya	≤1.0EU
Iintsimbi ezinzima	≤20ppm
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	API, COVID-19

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

Izinto eziluncedo:

FAQ:

Isicelo:

I-Remdesivir (i-CAS 1809249-37-3), ethengiswa phantsi kwegama le-brand Veklury, liyeza elibanzi lokulwa nentsholongwane eliphuhliswe yinkampani ye-biopharmaceutical yaseGilead Sciences.Isetyenziswa ngesitofu emithanjeni.Ngexesha lobhubhani we-COVID-19, i-remdesivir yamkelwa okanye yagunyaziswa ukuba isetyenziswe ngokungxamisekileyo ukunyanga i-COVID-19 kumazwe amalunga nama-50.Izikhokelo ezihlaziyiweyo ezivela kuMbutho wezeMpilo weHlabathi ngoNovemba ka-2020 zibandakanya isindululo esinemiqathango ngokuchasene nokusetyenziswa kwe-Remdesivir kunyango lwe-COVID-19.I-Remdesivir yaqala yaphuhliswa ukunyanga i-hepatitis C, kwaye emva koko yaphandwa ngenxa yesifo sentsholongwane ye-Ebola kunye nosulelo lwentsholongwane yaseMarburg ngaphambi kokuba ifundwe njengonyango lwasemva kokosulelwa yi-COVID-19.Impembelelo yecala eliqhelekileyo kumavolontiya aphilileyo iphakamisa amanqanaba egazi le-enzyme yesibindi (uphawu lweengxaki zesibindi).Esona siphumo sixhaphakileyo kubantu abane-COVID-19 sisicaphucaphu.Iziphumo ebezingalindelekanga zinokubandakanya ukudumba kwesibindi kunye nempendulo enxulumene nokutofa kunye nesicaphucaphu, uxinzelelo lwegazi oluphantsi, kunye nokubila.I-Remdesivir yiprodrug enenjongo yokuvumela ukuhanjiswa kwe-intracellular ye-GS-441524 monophosphate kunye ne-biotransformation elandelayo kwi-GS-441524 triphosphate, i-ribonucleotide analogue inhibitor ye-viral RNA polymerase.