I-Remdesivir Intermediate CAS 1911578-98-7 2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate

Inkcazelo emfutshane:

Igama leMchiza: 2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate

CAS: 1911578-98-7

Imbonakalo: Mhlophe ukuya kwi-Off-White PowderUbunyulu: ≥98.0%

Umbindi we-Remdesivir (CAS 1809249-37-3) COVID-19

Umgangatho ophezulu, iMveliso yoRhwebo

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Ubonelelo ngezoRhwebo loMvelisi i-Remdesivir kunye nabaPhakathi abaNxulumeneyo nabanoMgangatho oPhezulu
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Iipropati zeMichiza:

Igama leMchiza	2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate
Izithethantonye	N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester;I-Remdesivir ePhakathi;I-Remdesivir-001;Ukungacoceki kwe-Remdesivir 21
Inombolo yeCAS	1911578-98-7
Inombolo yeCAT	RF-PI303
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram
Ifomula yeemolekyuli	I-C21H27N2O7P
Ubunzima beMolekyuli	495.38
Ukuxinana	1.2g/cm3
Indawo yokunyibilika	92.0~96.0℃(lit.)
Indawo yokubilisa	356.7℃ ku-760 mmHg
Imeko yokuthumela ngenqanawa	Ithunyelwe Ngaphantsi Kweqondo Lobushushu Le-Ambient
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kwi-Off-White Powder
I-Infrared Spectrum	Iyahambelana neSakhiwo
Ubunyulu	≥99.0%
Ilahleko ekomisweni	≤0.50%
Ukungacoceki Okukodwa	≤0.50%
Ukungcola ngokupheleleyo	≤1.0%
Iintsimbi ezinzima	≤20ppm
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Umbindi we-Remdesivir (CAS 1809249-37-3)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

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Isicelo:

I-2-Ethylbutyl ((S)-(perfluorophenoxy) (phenoxy)phosphoryl)-L-alaninate (i-CAS 1911578-98-7) yinto ephambili engundoqo ephakathi ekulungiseleleni i-analog ehambelana ne-Remdesivir.I-Remdesivir yimveliso ye-monophosphoramidate ye-adenosine analog, luphando olubanzi lwe-antiviral agent ene-in vitro umsebenzi ngokuchasene ne-SARS coronavirus, i-MERS coronavirus kwaye, kutsha nje, i-Covid-19.I-Remdesivir yaphuhliswa kakhulu njengonyango losulelo lwe-filovirus olufana nesifo sentsholongwane ye-Ebola okanye intsholongwane kaMarburg.Emva koko, i-Remdesivir yafunyanwa ibonisa umsebenzi we-antiviral ngokuchasene nezinye iintsholongwane ze-RNA ezinemisonto enye enje ngentsholongwane yokuphefumla ye-syncytial virus, i-Nipah virus, i-Hendra virus, i-Junin virus, i-virus ye-Lassa fever kunye ne-coronavirus (kubandakanya i-MERS kunye neentsholongwane ze-SARS).Kutshanje isafundelwa njengeyeza elithembisayo lokunyanga i-COVID-19 (intsholongwane entsha yohlobo lwe-SARS).I-Remdesivir, ephuhliswe yiSayensi yaseGilead, i-adenosine prodrug eyenza i-metabolize ibe yifom esebenzayo i-GS-441524 ephazamisana nesenzo se-RNA exhomekeke kwi-RNA polymerase ye-viral kwaye ibalekela ukuhlolwa nge-viral exoribonuclease (ExoN), ebangela ukuncipha kwemveliso ye-RNA yentsholongwane.