I-Remdesivir Metabolite (GS-441524) CAS 1191237-69-0 COVID-19
Ubonelelo ngezoRhwebo loMvelisi i-Remdesivir kunye nabaPhakathi abaNxulumeneyo nabanoMgangatho oPhezulu
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Izithethantonye | GS-441524;I-Remdesivir Metabolite;I-Remdesivir ePhakathi;I-Nucleosid ye-Remdesivir;EVO984;I-Remdesivir O-Desphosphate Analogue;I-Remdesivir Related Compound 6 Ukungacoceki |
Inombolo yeCAS | 1191237-69-0 |
Inombolo yeCAT | RF-PI299 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram |
Ifomula yeemolekyuli | C12H13N5O4 |
Ubunzima beMolekyuli | 291.26 |
Ukunyibilika | Inyibilika kwi-DMSO |
Indawo yokugcina | Indawo eyomileyo epholileyo |
Imeko yokuthumela ngenqanawa | Ithunyelwe Ngaphantsi Kweqondo Lobushushu Le-Ambient |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya Phantse uMhlophe |
Ubunyulu | ≥99.0% |
Alpha-Isomer | ≤0.30% |
I-O-Bn Derivative | ≤0.30% |
N-Bn Derivative | ≤0.30% |
Ukungacoceki okuphezulu okukodwa | ≤0.30% |
Ilahleko ekomisweni | ≤1.0% |
Intsalela kwi-Ignition | ≤0.50% |
Iintsimbi ezinzima | ≤20ppm |
Arsenic | ≤2ppm |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Umbindi weRemdesivir (CAS 1809249-37-3);I-COVID 19 |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-analogue ye-Remdesivir nucleoside (GS-441524, CAS 1191237-69-0) iyibhloko yokwakha ebalulekileyo kwi-synthesis ye-Remdesivir triphosphate (1355149-45-9) kunye ne-Remdesivir (1809249-37-3).I-GS-441524 lichiza le-nucleoside analogue antiviral elaphuhliswa yiNzululwazi yaseGiliyadi.Le analog ye-phosphorus ikakhulu iyikhompawundi esebenzayo kunyango lwe-Ebola kunye ne-COVID-19.Yeyona plasma imetabolite ye-antiviral prodrug remdesivir, kwaye inobomi besiqingatha malunga neeyure ezingama-24 kwizigulana ezingabantu.I-Remdesivir kunye ne-GS-441524 zombini zifunyenwe zisebenza kwi-vitro ngokuchasene ne-feline coronavirus strains enoxanduva lwe-feline infectious peritonitis (FIP), isifo esibulalayo esichaphazela iikati zasekhaya.