Roflumilast CAS 162401-32-3 Assay 99.0~101.0% API

Inkcazelo emfutshane:

Igama leKhemikhali: Roflumilast

CAS: 162401-32-3

Uvavanyo: 99.0 ~ 101.0% (Ibalwe kwisiseko esomileyo)

Imbonakalo: Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe

API PDE-4 Inhibitor COPD

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical Supply Roflumilast Intermediates:
Roflumilast CAS 162401-32-3
4-Amino-3,5-Dichloropyridine CAS 22889-78-7

Iipropati zeMichiza:

Igama leMchiza	Roflumilast
Izithethantonye	3-(Cyclopropylmethoxy)-N-(3,5-Dichloropyridin-4-yl)-4-(Ddifluoromethoxy)benzamide
Inombolo yeCAS	162401-32-3
Inombolo yeCAT	RF-PI2075
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C17H14Cl2F2N2O3
Ubunzima beMolekyuli	403.21
Ukuxinana	1.471±0.060 g/cm3
Uvakalelo	Ubushushu Bubuthathaka
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe
Ukunyibilika	Inyibilikiswa simahla kwi-acetone, ayinyibiliki kancinci kwi-acetronitrile, ayinyibiliki kancinci kwi-anhydrous ethanol, ayinyibiliki ngokuthe ngqo emanzini.
Indawo yokunyibilika	157.0 ~ 162.0℃
Ilahleko ekomisweni	<0.50%
Intsalela kwi-Ignition	≤0.10%
Iintsimbi ezinzima	≤10ppm
I-Chloride	≤0.01%
Isazisi A. UV	Ubude obuphezulu bokufunxa kufuneka bube kwi-213 ~ 251nm
Isazisi B. IR	Uluhlu lokufunxa lwe-IR lwesampulu luhambelana naleyo yereferensi enye
Isazisi C.	Ibonisa ukusabela kweFluoride
Izinto ezinxulumeneyo
Ukungacoceki Okukodwa	≤0.10%
Ukungcola ngokupheleleyo	<0.50%
Izinyibilikisi ezishiyekileyo
Tert-Butanol	<0.10%
Tetrahydrofuran	<0.072%
Toluene	<0.089%
N, N-Dimethylformamide	<0.088%
Isivavanyi	99.0 ~ 101.0% (Ibalwe kwisiseko esomileyo)
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	API;I-COPD

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

I-Roflumilast (i-CAS: i-162401-32-3) yinto ekhethiweyo yomlomo we-phosphodiesterase-4 (PDE-4) inhibitor kunye ne-benzamide compound.Yaphuhliswa yinkampani yaseJamani iAltana ngo-1993 kwaye iyona kuphela inhibitor yomlomo ye-PDE-4 esetyenziselwa ukunyanga izifo zendlela yokuphefumla evunyiweyo ukuba ithengiswe.I-Roflumilast lichiza lokuqala lohlobo lwayo ukujolisa kwisifo semiphunga esingapheliyo esingapheliyo (COPD), kwaye ikwalichiza lokuqala lomlomo elichasene nokudumba elenzelwe izigulana zeCOPD.Iimpawu zayo ezizodwa zinokunceda ukulawula i-COPD: xa isetyenziswe ngokudibeneyo kunye ne-bronchodilators ukunyanga izigulane ze-COPD ezinzima kakhulu, i-Roflumilast ingaba nenzuzo yokunciphisa ngakumbi iimpawu kunye nezinga lokuwohloka, ngaloo ndlela iyenze ibe liyeza lokuqala elijolise kwizigulane ezine-phenotype-spAecific COPD eqhubekayo. kunye nokuphazamiseka okukhulu kokuhamba komoya okunxulumene nokukhohlela okungapheliyo kunye ne-phlegm engaphezulu.Ngaphandle kokuba lunyango lweCOPD enzima, iRoflumilast inokusetyenziselwa ukuthintela kunye nokunyanga izifo zendlela yokuphefumla yemfuyo, ukukhohlela kwe-mucosa engaphezulu kwe-bronchitis, i-asthmatic bronchitis, kunye ne-bronchitis ebukhali kunye ne-sacculitis yomoya ehamba kunye nokukhutshwa kwephecana lokuphefumla ngokungaqhelekanga.