(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Intermediate Purity >99.0% (GC)

Inkcazelo emfutshane:

Igama leMichiza: (S)-1-Boc-3-Hydroxypiperidine

CAS: 143900-44-1

Ukucoceka kweChiral: >99.0% (GC)

Ukucoceka kwemichiza: >99.0% (GC)

Imbonakalo: Umgubo oMhlophe okanye iiCrystals

Umbindi we-Ibrutinib (CAS: 936563-96-1)

Umgangatho ophezulu, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ibrutinib eNxulumene nayo:
(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1
I-4-Phenoxyphenylboronic Acid CAS 51067-38-0
Ibrutinib Intermediate N-2 CAS 330786-24-8
Ibrutinib Intermediate N-3 CAS 330792-70-6
Ibrutinib CAS 936563-96-1

Iipropati zeMichiza:

Igama leMchiza	(S) -1-Boc-3-Hydroxypiperidine
Izithethantonye	(S) -1-(tert-Butoxycarbonyl)-3-Hydroxypiperidine;(S)-1-Boc-3-Piperidinol
Inombolo yeCAS	143900-44-1
Inombolo yeCAT	RF-CC299
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso yeeToni ezingama-20 / ngenyanga
Ifomula yeemolekyuli	C10H19NO3
Ubunzima beMolekyuli	201.27
Indawo yokunyibilika	52.0 ~ 56.0℃
Ukunyibilika	Inyibilika kwiMethanol
Ujikelezo oluKhethekileyo [a]20/D	+9.0°~+11.0° (C=1 kwiChloroform)
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oMhlophe okanye iiCrystals
Ucoceko lweChiral	>99.5% (GC)
Ucoceko lweMichiza	>99.5% (GC)
Amanzi (KF)	≤0.50%
IMethanol (GC)	≤50ppm
I-Ethanol (GC)	≤50ppm
I-DCM (GC)	≤500ppm
3-Hydroxypiperidine	≤0.10%
3-Hydroxypyridine	≤0.20%
1-Boc-3-Piperidone	≤0.10%
I-1-Boc-4-Hydroxypiperidine	≤0.10%
1.96 RRT	≤0.20%
Nakuphi na Ukungcola Okungachazwanga	≤0.10%
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	abaPhakathi bamayeza;IiCompounds zeChiral

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.

Izinto eziluncedo:

FAQ:

Isicelo:

(S) -1-Boc-3-Hydroxypiperidine (i-CAS: 143900-44-1) yinto ebalulekileyo ye-chiral ephakathi kwi-synthesis ye-Ibrutinib (CAS: 936563-96-1).I-Ibrutinib luhlobo lwe-Bruton tyrosine kinase (BTK) inhibitor, ingasetyenziselwa unyango lwe-lymphocytic leukemia engapheliyo (CLL) kunye ne-mantle cell lymphoma (MCL).I-MCL kunye ne-CLL zeze-B-cell non-Hodgkin's lymphoma, ekunzima ukuyinyanga kwaye kulula ukuyiphinda.I-chemical immunotherapy eqhelekileyo ayinakho ukujoliswa, idla ngokuvela kwi-3 okanye i-4 yokusabela okubi.I-Ibrutinib kunye ne-B lymphocytes zinokujolisa nge-BTK eyimfuneko ekubunjweni, ukwahlula, kunye nokusasazwa kolwazi, inqanda umsebenzi we-BTK ngokungaguqukiyo, kwaye inqanda ukwanda kweeseli zesisu kunye nokuphila ngokufanelekileyo.I-Ibrutinib inokuthi ifakwe ngokukhawuleza emva kokulawulwa komlomo, ngexesha le-1 ~ 2h ifikelele ekugxininiseni kwegazi eliphezulu, ukusabela okungalunganga kukunye okanye ezimbini, ngoko ke, i-Ibrutinib iya kuba yinto entsha yonyango lwe-CLL kunye ne-MCL.